Target Interacting Protein Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T20891 | Target Info | |||
| Target Name | Phosphoinositide dependent protein kinase-1 (PDPK1) | ||||
| Synonyms | PDK1; HPDK1; 3-phosphoinositide-dependent protein kinase 1; 3-Phosphoinositide-dependent kinase-1; 3'-phosphoinositide dependent kinase 1 | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | PDPK1 | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Target Interacting Proteins | Top | ||||
|---|---|---|---|---|---|
| Kinases | [+] 5 Kinases | + | |||
| Interacting Target Name | Protein kinase C zeta (PRKCZ) | Patented-recorded Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | Protein kinase C zeta type; PKC2; NPKC-zeta | ||||
| Evidence Score (E-score) | 4 Experimental Evidences | + | |||
| 1 | Affinity Capture-Western | [1] | |||
| 2 | Biochemical Activity | [2] | |||
| 3 | Reconstituted Complex | [3] | |||
| 4 | Yeast two hybrid | [4] | |||
| Interacting Target Name | RAC-alpha serine/threonine-protein kinase (AKT1) | Successful Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | RAC-PK-alpha; RAC; Proto-oncogene c-Akt; Protein kinase B alpha; Protein kinase B; PKB alpha; PKB | ||||
| Evidence Score (E-score) | 2 Experimental Evidences | + | |||
| 1 | Affinity Capture-Western | [5] | |||
| 2 | Biochemical Activity | [6] | |||
| Interacting Target Name | Serine/threonine-protein kinase Sgk1 (SGK1) | Clinical trial Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | SGK; Serum/glucocorticoid-regulated kinase 1 | ||||
| Evidence Score (E-score) | 2 Experimental Evidences | + | |||
| 1 | Biochemical Activity | [7] | |||
| 2 | Reconstituted Complex | [3] | |||
| Interacting Target Name | Ribosomal protein S6 kinase alpha-3 (RSK3) | Patented-recorded Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | S6K-alpha-3; RSK-2; RSK2; Ribosomal S6 kinase 2; pp90RSK2; p90RSK3; p90-RSK 3; MAPKAPK-1b; MAPKAPK1B; MAPKAP kinase 1b; MAPK-activated protein kinase 1b; MAP kinase-activated protein kinase 1b; ISPK-1; ISPK1; Insulin-stimulated protein kinase 1; 90 kDa ribosomal protein S6 kinase 3 | ||||
| Evidence Score (E-score) | 2 Experimental Evidences | + | |||
| 1 | Affinity Capture-Western | [8] | |||
| 2 | Co-localization | [9] | |||
| Interacting Target Name | Protein kinase N2 (PKN2) | Literature-reported Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | Serine/threonine-protein kinase N2; Protein-kinase C-related kinase 2; Protein kinase C-like 2; PRKCL2; PRK2; PKN gamma | ||||
| Evidence Score (E-score) | 2 Experimental Evidences | + | |||
| 1 | Affinity Capture-Western | [1] | |||
| 2 | Yeast two hybrid | [4] | |||
| Other proteins | [+] 1 Other proteins | + | |||
| Interacting Protein Name | Caspase recruitment domain-containing protein 11 (CARD11) | Interacting Protein | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | BENTA; BIMP3; CARMA1; IMD11; PPBL | ||||
| Evidence Score (E-score) | 2 Experimental Evidences | + | |||
| 1 | Affinity Capture-Western | [10] | |||
| 2 | Yeast two hybrid | [11] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Regulation of both PDK1 and the phosphorylation of PKC-zeta and -delta by a C-terminal PRK2 fragment. Biochemistry. 2002 Jan 15;41(2):561-9. | ||||
| REF 2 | Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1. Science. 1998 Sep 25;281(5385):2042-5. | ||||
| REF 3 | Serum and glucocorticoid-inducible kinase (SGK) is a target of the PI 3-kinase-stimulated signaling pathway. EMBO J. 1999 Jun 1;18(11):3024-33. | ||||
| REF 4 | A 3-phosphoinositide-dependent protein kinase-1 (PDK1) docking site is required for the phosphorylation of protein kinase Czeta (PKCzeta ) and PKC-related kinase 2 by PDK1. J Biol Chem. 2000 Jul 7;275(27):20806-13. | ||||
| REF 5 | Protein kinase B is regulated in platelets by the collagen receptor glycoprotein VI. J Biol Chem. 2002 Apr 12;277(15):12874-8. | ||||
| REF 6 | An ATP-site on-off switch that restricts phosphatase accessibility of Akt. Sci Signal. 2012 May 8;5(223):ra37. | ||||
| REF 7 | NM23-H1 tumor suppressor and its interacting partner STRAP activate p53 function. J Biol Chem. 2007 Nov 30;282(48):35293-307. | ||||
| REF 8 | A phosphoserine-regulated docking site in the protein kinase RSK2 that recruits and activates PDK1. EMBO J. 2000 Jun 15;19(12):2924-34. | ||||
| REF 9 | Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network. J Proteome Res. 2014 Dec 5;13(12):5339-46. | ||||
| REF 10 | PDK1 nucleates T cell receptor-induced signaling complex for NF-kappaB activation. Science. 2005 Apr 1;308(5718):114-8. | ||||
| REF 11 | A directed protein interaction network for investigating intracellular signal transduction. Sci Signal. 2011 Sep 6;4(189):rs8. | ||||
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