Target Interacting Protein Information
Target General Information | Top | ||||
---|---|---|---|---|---|
Target ID | T16902 | Target Info | |||
Target Name | Histone acetyltransferase KAT2B (KAT2B) | ||||
Synonyms | Spermidine acetyltransferase KAT2B; PCAF; P300/CBP-associated factor; P/CAF; Lysine acetyltransferase 2B; Histone acetyltransferase PCAF; Histone acetylase PCAF | ||||
Target Type | Literature-reported Target | ||||
Gene Name | KAT2B | ||||
Biochemical Class | Acyltransferase | ||||
UniProt ID |
Target Interacting Proteins | Top | ||||
---|---|---|---|---|---|
Acyltransferases | [+] 2 Acyltransferases | + | |||
Interacting Target Name | Histone acetyltransferase p300 (EP300) | Clinical trial Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | Protein propionyltransferase p300; p300 HAT; P300; Histone crotonyltransferase p300; Histone butyryltransferase p300; E1A-associated protein p300; E1Aassociated protein p300 | ||||
Evidence Score (E-score) | 3 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [1] | |||
2 | Biochemical Activity | [2] | |||
3 | Reconstituted Complex | [3] | |||
Interacting Protein Name | Nuclear receptor coactivator 1 (NCOA1) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | F.SRC.1; KAT13A; RIP160; SRC1; bHLHe42; bHLHe74 | ||||
Evidence Score (E-score) | 3 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [4] | |||
2 | Yeast two hybrid | [5] | |||
3 | Yeast two hybrid | [4] | |||
Beta-transducin repeats | [+] 1 Beta-transducin repeats | + | |||
Interacting Target Name | WD repeat-containing protein 5 (WDR5) | Literature-reported Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | BMP2-induced 3-kb gene protein; BIG3 | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [6] | |||
2 | Affinity Capture-Western | [7] | |||
Histones | [+] 1 Histones | + | |||
Interacting Protein Name | Histone H4 (H4) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | H4FA | ||||
Evidence Score (E-score) | 8 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [8] | |||
2 | Biochemical Activity | [9] | |||
3 | Biochemical Activity | [10] | |||
4 | Biochemical Activity | [11] | |||
5 | Biochemical Activity | [12] | |||
6 | Biochemical Activity | [13] | |||
7 | Biochemical Activity | [14] | |||
8 | Biochemical Activity | [15] | |||
Kinases | [+] 1 Kinases | + | |||
Interacting Protein Name | Transformation/transcription domain-associated protein (TRRAP) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | PAF350/400; PAF400; STAF40; TR.AP; Tra1 | ||||
Evidence Score (E-score) | 4 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [16] | |||
2 | Affinity Capture-Western | [17] | |||
3 | Affinity Capture-Western | [16] | |||
4 | Co-purification | [18] | |||
Nuclear hormone receptors | [+] 1 Nuclear hormone receptors | + | |||
Interacting Target Name | Progesterone receptor (PGR) | Successful Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | PR; Nuclear receptor subfamily 3 group C member 3; NR3C3 | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [19] | |||
2 | Reconstituted Complex | [20] | |||
One-carbon transferases | [+] 1 One-carbon transferases | + | |||
Interacting Protein Name | Histone-lysine N-methyltransferase MECOM (MECOM) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | AML1.EVI.1; EVI1; MDS1; MDS1.EVI1; PRDM3 | ||||
Evidence Score (E-score) | 3 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [21] | |||
2 | Affinity Capture-Western | [22] | |||
3 | Biochemical Activity | [21] | |||
Pore-forming toxins | [+] 1 Pore-forming toxins | + | |||
Interacting Target Name | Cellular tumor antigen p53 (TP53) | Clinical trial Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | Tumor suppressor p53; Phosphoprotein p53; P53; Antigen NY-CO-13 | ||||
Evidence Score (E-score) | 12 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [23] | |||
2 | Affinity Capture-Western | [24] | |||
3 | Affinity Capture-Western | [25] | |||
4 | Biochemical Activity | [26] | |||
5 | Biochemical Activity | [27] | |||
6 | Biochemical Activity | [28] | |||
7 | Biochemical Activity | [29] | |||
8 | Biochemical Activity | [30] | |||
9 | Biochemical Activity | [31] | |||
10 | Biochemical Activity | [32] | |||
11 | Biochemical Activity | [33] | |||
12 | Reconstituted Complex | [31] | |||
Transcription regulators | [+] 8 Transcription regulators | + | |||
Interacting Target Name | DNA-binding protein SATB1 (SATB1) | Literature-reported Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | Special AT-rich sequence-binding protein 1 | ||||
Evidence Score (E-score) | 4 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [34] | |||
2 | Biochemical Activity | [34] | |||
3 | Biochemical Activity | [35] | |||
4 | Reconstituted Complex | [34] | |||
Interacting Protein Name | Krueppel-like factor 13 (KLF13) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | BTEB3; FKLF2; NSLP1; RFLAT.1; RFLAT1 | ||||
Evidence Score (E-score) | 4 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [36] | |||
2 | Biochemical Activity | [36] | |||
3 | Biochemical Activity | [37] | |||
4 | Reconstituted Complex | [36] | |||
Interacting Target Name | CREB-binding protein (CREBBP) | Clinical trial Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | CREBbinding protein; CBP | ||||
Evidence Score (E-score) | 3 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [38] | |||
2 | Affinity Capture-Western | [3] | |||
3 | Yeast two hybrid | [4] | |||
Interacting Target Name | Hypoxia-inducible factor 1 alpha (HIF-1A) | Clinical trial Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | Transcription factor HIF-1; PASD8; PAS domain-containing protein 8; MOP1; Member of PAS protein 1; Hypoxia-inducible transcription factor (HIF)-1; Hypoxia-inducible factor 1-alpha; Hypoxia-inducible factor 1; Hypoxia inducible factor 1; HIF-1-alpha; HIF-1alpha; HIF1-alpha; HIF-1 alpha; HIF1 alpha; Class E basic helix-loop-helix protein 78; bHLHe78; Basic-helix-loop-helix-PAS protein MOP1; ARNT-interacting protein; ARNT interacting protein | ||||
Evidence Score (E-score) | 3 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [39] | |||
2 | Affinity Capture-Western | [40] | |||
3 | Biochemical Activity | [41] | |||
Interacting Protein Name | Interferon regulatory factor 2 (IRF2) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | IRF.2 | ||||
Evidence Score (E-score) | 3 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [42] | |||
2 | Biochemical Activity | [42] | |||
3 | Reconstituted Complex | [43] | |||
Interacting Target Name | Interferon regulatory factor 1 (IRF1) | Literature-reported Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | IRF-1 | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [44] | |||
2 | Reconstituted Complex | [43] | |||
Interacting Target Name | Mothers against decapentaplegic homolog 3 (SMAD3) | Preclinical Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | TGF-beta response effector Smad3; Smad3; SMAD family member 3; SMAD 3; Mothers against DPP homolog 3; MMad3; MADH3; Mad3; MAD homolog 3; JV15-2; HSMAD3; HMAD-3 | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [45] | |||
2 | Reconstituted Complex | [46] | |||
Interacting Protein Name | Myoblast determination protein 1 (MYOD1) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | MYF3; MYOD; PUM; bHLHc1 | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [47] | |||
2 | Biochemical Activity | [48] | |||
Ubiquitin related proteins | [+] 1 Ubiquitin related proteins | + | |||
Interacting Target Name | Ubiquitin-protein ligase E3 Mdm2 (MDM2) | Clinical trial Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | RING-type E3 ubiquitin transferase Mdm2; P53-binding protein Mdm2; Oncoprotein Mdm2; MDM2 protein; Hdm2; E3 ubiquitin-protein ligase Mdm2; Double minute 2 protein | ||||
Evidence Score (E-score) | 3 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [26] | |||
2 | Biochemical Activity | [49] | |||
3 | Biochemical Activity | [50] | |||
Other proteins | [+] 1 Other proteins | + | |||
Interacting Target Name | Breast cancer type 2 susceptibility protein (BRCA2) | Literature-reported Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | Fanconi anemia group D1 protein; FANCD1; FACD | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [51] | |||
2 | Reconstituted Complex | [51] |
References | Top | ||||
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REF 1 | Parathyroid hormone activation of matrix metalloproteinase-13 transcription requires the histone acetyltransferase activity of p300 and PCAF and p300-dependent acetylation of PCAF. J Biol Chem. 2010 Dec 3;285(49):38014-22. | ||||
REF 2 | Post-activation turn-off of NF-kappa B-dependent transcription is regulated by acetylation of p65. J Biol Chem. 2003 Jan 24;278(4):2758-66. | ||||
REF 3 | A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A. Nature. 1996 Jul 25;382(6589):319-24. | ||||
REF 4 | Transcription factor-specific requirements for coactivators and their acetyltransferase functions. Science. 1998 Jan 30;279(5351):703-7. | ||||
REF 5 | Steroid receptor coactivator-1 is a histone acetyltransferase. Nature. 1997 Sep 11;389(6647):194-8. | ||||
REF 6 | Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509. | ||||
REF 7 | Human ATAC Is a GCN5/PCAF-containing acetylase complex with a novel NC2-like histone fold module that interacts with the TATA-binding protein. J Biol Chem. 2008 Dec 5;283(49):33808-15. | ||||
REF 8 | Histone acetyltransferase PCAF up-regulated cell apoptosis in hepatocellular carcinoma via acetylating histone H4 and inactivating AKT signaling. Mol Cancer. 2013 Aug 27;12(1):96. | ||||
REF 9 | Glucocorticoid receptor recruitment of histone deacetylase 2 inhibits interleukin-1beta-induced histone H4 acetylation on lysines 8 and 12. Mol Cell Biol. 2000 Sep;20(18):6891-903. | ||||
REF 10 | Regulation of histone acetylation and transcription by nuclear protein pp32, a subunit of the INHAT complex. J Biol Chem. 2002 Apr 19;277(16):14005-10. | ||||
REF 11 | AML1 is functionally regulated through p300-mediated acetylation on specific lysine residues. J Biol Chem. 2004 Apr 9;279(15):15630-8. | ||||
REF 12 | p66alpha and p66beta of the Mi-2/NuRD complex mediate MBD2 and histone interaction. Nucleic Acids Res. 2006 Jan 13;34(2):397-406. | ||||
REF 13 | HIV-1 Tat interactions with p300 and PCAF transcriptional coactivators inhibit histone acetylation and neurotrophin signaling through CREB. J Biol Chem. 2005 Mar 11;280(10):9390-9. | ||||
REF 14 | Human Elongator facilitates RNA polymerase II transcription through chromatin. Proc Natl Acad Sci U S A. 2002 Feb 5;99(3):1241-6. | ||||
REF 15 | A new coactivator function for Zac1's C2H2 zinc finger DNA-binding domain in selectively controlling PCAF activity. Mol Cell Biol. 2008 Oct;28(19):6078-93. | ||||
REF 16 | The 400 kDa subunit of the PCAF histone acetylase complex belongs to the ATM superfamily. Mol Cell. 1998 Dec;2(6):869-75. | ||||
REF 17 | The p400 complex is an essential E1A transformation target. Cell. 2001 Aug 10;106(3):297-307. | ||||
REF 18 | Involvement of the TIP60 histone acetylase complex in DNA repair and apoptosis. Cell. 2000 Aug 18;102(4):463-73. | ||||
REF 19 | Steroid receptor coactivator-3 is required for progesterone receptor trans-activation of target genes in response to gonadotropin-releasing hormone treatment of pituitary cells. J Biol Chem. 2006 Jul 28;281(30):20817-24. | ||||
REF 20 | Steroid receptor induction of gene transcription: a two-step model. Proc Natl Acad Sci U S A. 1997 Jul 22;94(15):7879-84. | ||||
REF 21 | Interaction of EVI1 with cAMP-responsive element-binding protein-binding protein (CBP) and p300/CBP-associated factor (P/CAF) results in reversible acetylation of EVI1 and in co-localization in nuclear speckles. J Biol Chem. 2001 Nov 30;276(48):44936-43. | ||||
REF 22 | Acetylation of lysine 564 adjacent to the C-terminal binding protein-binding motif in EVI1 is crucial for transcriptional activation of GATA2. J Biol Chem. 2010 May 28;285(22):16967-77. | ||||
REF 23 | Restoration of DNA-binding and growth-suppressive activity of mutant forms of p53 via a PCAF-mediated acetylation pathway. J Cell Physiol. 2010 Nov;225(2):394-405. | ||||
REF 24 | Acetylation of p53 at lysine 373/382 by the histone deacetylase inhibitor depsipeptide induces expression of p21(Waf1/Cip1). Mol Cell Biol. 2006 Apr;26(7):2782-90. | ||||
REF 25 | An ATM- and Rad3-related (ATR) signaling pathway and a phosphorylation-acetylation cascade are involved in activation of p53/p21Waf1/Cip1 in response to 5-aza-2'-deoxycytidine treatment. J Biol Chem. 2008 Feb 1;283(5):2564-74. | ||||
REF 26 | MDM2 inhibits PCAF (p300/CREB-binding protein-associated factor)-mediated p53 acetylation. J Biol Chem. 2002 Aug 23;277(34):30838-43. | ||||
REF 27 | Regulation of hormone-induced histone hyperacetylation and gene activation via acetylation of an acetylase. Cell. 1999 Sep 3;98(5):675-86. | ||||
REF 28 | Tip60-dependent acetylation of p53 modulates the decision between cell-cycle arrest and apoptosis. Mol Cell. 2006 Dec 28;24(6):827-39. | ||||
REF 29 | p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damage. Mol Cell Biol. 1999 Feb;19(2):1202-9. | ||||
REF 30 | DNA damage activates p53 through a phosphorylation-acetylation cascade. Genes Dev. 1998 Sep 15;12(18):2831-41. | ||||
REF 31 | Human immunodeficiency virus type-1 Tat/co-activator acetyltransferase interactions inhibit p53Lys-320 acetylation and p53-responsive transcription. J Biol Chem. 2003 Apr 4;278(14):12310-8. | ||||
REF 32 | p300 regulates p63 transcriptional activity. J Biol Chem. 2005 Aug 26;280(34):30604-10. | ||||
REF 33 | CK2 is the regulator of SIRT1 substrate-binding affinity, deacetylase activity and cellular response to DNA-damage. PLoS One. 2009 Aug 14;4(8):e6611. | ||||
REF 34 | Phosphorylation of SATB1, a global gene regulator, acts as a molecular switch regulating its transcriptional activity in vivo. Mol Cell. 2006 Apr 21;22(2):231-43. | ||||
REF 35 | SIRT1 deacetylates SATB1 to facilitate MAR HS2-MAR interaction and promote -globin expression. Nucleic Acids Res. 2012 Jun;40(11):4804-15. | ||||
REF 36 | Functional interaction between coactivators CBP/p300, PCAF, and transcription factor FKLF2. J Biol Chem. 2002 Mar 1;277(9):7029-36. | ||||
REF 37 | Functional interplay between CBP and PCAF in acetylation and regulation of transcription factor KLF13 activity. J Mol Biol. 2003 May 30;329(2):207-15. | ||||
REF 38 | A human RNA polymerase II complex containing factors that modify chromatin structure. Mol Cell Biol. 1998 Sep;18(9):5355-63. | ||||
REF 39 | Sirtuin 1 modulates cellular responses to hypoxia by deacetylating hypoxia-inducible factor 1alpha. Mol Cell. 2010 Jun 25;38(6):864-78. | ||||
REF 40 | Human papillomavirus E7 enhances hypoxia-inducible factor 1-mediated transcription by inhibiting binding of histone deacetylases. Cancer Res. 2011 Feb 1;71(3):1187-95. | ||||
REF 41 | HIF1 protein stability is increased by acetylation at lysine 709. J Biol Chem. 2012 Oct 12;287(42):35496-505. | ||||
REF 42 | Coactivator p300 acetylates the interferon regulatory factor-2 in U937 cells following phorbol ester treatment. J Biol Chem. 2001 Jun 15;276(24):20973-80. | ||||
REF 43 | The histone acetylase PCAF is a phorbol-ester-inducible coactivator of the IRF family that confers enhanced interferon responsiveness. Mol Cell Biol. 1999 Mar;19(3):1810-20. | ||||
REF 44 | p300, but not PCAF, collaborates with IRF-1 in stimulating TRIM22 expression independently of its histone acetyltransferase activity. Eur J Immunol. 2013 Aug;43(8):2174-84. | ||||
REF 45 | Characterization of a novel transcriptionally active domain in the transforming growth factor beta-regulated Smad3 protein. Nucleic Acids Res. 2005 Jul 1;33(12):3708-21. | ||||
REF 46 | The transcriptional co-activator P/CAF potentiates TGF-beta/Smad signaling. Nucleic Acids Res. 2000 Nov 1;28(21):4291-8. | ||||
REF 47 | P/CAF mediates PAX3-FOXO1-dependent oncogenesis in alveolar rhabdomyosarcoma. J Pathol. 2016 Nov;240(3):269-281. | ||||
REF 48 | CREB-binding protein/p300 activates MyoD by acetylation. J Biol Chem. 2000 Nov 3;275(44):34359-64. | ||||
REF 49 | Pulling a Ligase out of a "HAT": pCAF Mediates Ubiquitination of the Class II Transactivator. Int J Cell Biol. 2017;2017:8093813. | ||||
REF 50 | Enigma negatively regulates p53 through MDM2 and promotes tumor cell survival in mice. J Clin Invest. 2010 Dec;120(12):4493-506. | ||||
REF 51 | BRCA2 associates with acetyltransferase activity when bound to P/CAF. Oncogene. 1998 Nov 12;17(19):2531-4. |
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