Target Interacting Protein Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T16868 | Target Info | |||
| Target Name | Neural cadherin (CDH2) | ||||
| Synonyms | NCAD; N-cadherin; Cadherin-2; CDw325; CDHN; CD325 | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | CDH2 | ||||
| Biochemical Class | Cadherin protein | ||||
| UniProt ID | |||||
| Target Interacting Proteins | Top | ||||
|---|---|---|---|---|---|
| Other proteins | [+] 4 Other proteins | + | |||
| Interacting Target Name | Beta-catenin (CTNNB1) | Successful Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | Wnt/beta-catenin signaling pathway; PRO2286; OK/SW-cl.35; CTNNB; Catenin beta-1 | ||||
| Evidence Score (E-score) | 5 Experimental Evidences | + | |||
| 1 | Affinity Capture-MS | [1] | |||
| 2 | Affinity Capture-Western | [2] | |||
| 3 | Affinity Capture-Western | [3] | |||
| 4 | Affinity Capture-Western | [4] | |||
| 5 | Affinity Capture-Western | [5] | |||
| Interacting Target Name | Junction plakoglobin (JUP) | Literature-reported Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | Plakoglobin; DP3; Desmoplakin-3; Desmoplakin III; CTNNG; Catenin gamma | ||||
| Evidence Score (E-score) | 3 Experimental Evidences | + | |||
| 1 | Affinity Capture-MS | [1] | |||
| 2 | Affinity Capture-Western | [6] | |||
| 3 | Co-fractionation | [7] | |||
| Interacting Protein Name | Catenin alpha-1 (CTNNA1) | Interacting Protein | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | CAP102 | ||||
| Evidence Score (E-score) | 3 Experimental Evidences | + | |||
| 1 | Affinity Capture-MS | [1] | |||
| 2 | Affinity Capture-Western | [2] | |||
| 3 | Co-fractionation | [7] | |||
| Interacting Protein Name | Catenin delta-1 (CTNND1) | Interacting Protein | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | CAS; CTNND; P120CAS; P120CTN; p120; p120(CAS); p120(CTN) | ||||
| Evidence Score (E-score) | 2 Experimental Evidences | + | |||
| 1 | Affinity Capture-MS | [1] | |||
| 2 | Affinity Capture-Western | [2] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | A novel cell-cell junction system: the cortex adhaerens mosaic of lens fiber cells. J Cell Sci. 2003 Dec 15;116(Pt 24):4985-95. | ||||
| REF 2 | N-cadherin-catenin complexes form prior to cleavage of the proregion and transport to the plasma membrane. J Biol Chem. 2003 May 9;278(19):17269-76. | ||||
| REF 3 | Wnt signaling during BMP-2 stimulation of mesenchymal chondrogenesis. J Cell Biochem. 2002;84(4):816-31. | ||||
| REF 4 | Regulation of S33/S37 phosphorylated beta-catenin in normal and transformed cells. J Cell Sci. 2002 Jul 1;115(Pt 13):2771-80. | ||||
| REF 5 | Fbxo45 inhibits calcium-sensitive proteolysis of N-cadherin and promotes neuronal differentiation. J Biol Chem. 2014 Oct 10;289(41):28448-59. | ||||
| REF 6 | Identification of plakoglobin domains required for association with N-cadherin and alpha-catenin. J Biol Chem. 1995 Aug 25;270(34):20201-6. | ||||
| REF 7 | A census of human soluble protein complexes. Cell. 2012 Aug 31;150(5):1068-81. | ||||
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