Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T14030 Target Info
Target Name Ras-related protein Rab-7a (RAB7A)
Synonyms RAB7
Target Type Literature-reported Target
Gene Name RAB7A
Biochemical Class Small GTPase
UniProt ID
RAB7A_HUMAN 
Target Interacting Proteins  Top
Acid anhydride hydrolases [+] 2 Acid anhydride hydrolases +
Interacting Protein Name Ras-related protein Rab-5A (RAB5A) Interacting Protein Interacting Protein Info
UniProt ID
RAB5A_HUMAN 
Synonyms RAB5
Evidence Score (E-score) 2 Experimental Evidences +
1 Co-fractionation [1]
2 Yeast two hybrid [2]
Interacting Protein Name Ras-related protein Rab-5B (RAB5B) Interacting Protein Interacting Protein Info
UniProt ID
RAB5B_HUMAN 
Evidence Score (E-score) 2 Experimental Evidences +
1 Co-fractionation [1]
2 Yeast two hybrid [2]
Other proteins [+] 2 Other proteins +
Interacting Protein Name Rab-interacting lysosomal protein (RILP) Interacting Protein Interacting Protein Info
UniProt ID
RILP_HUMAN 
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Affinity Capture-Western [4]
3 Reconstituted Complex [5]
4 Reconstituted Complex [6]
5 Yeast two hybrid [5]
Interacting Protein Name Rab proteins geranylgeranyltransferase component A 1 (CHM) Interacting Protein Interacting Protein Info
UniProt ID
RAE1_HUMAN 
Synonyms DXS540; GGTA; HSD.32; REP.1; TCD
Evidence Score (E-score) 2 Experimental Evidences +
1 Co-crystal Structure [7]
2 Reconstituted Complex [8]
References  Top
REF 1 Panorama of ancient metazoan macromolecular complexes. Nature. 2015 Sep 17;525(7569):339-44.
REF 2 Interaction cloning and characterization of the cDNA encoding the human prenylated rab acceptor (PRA1). Biochem Biophys Res Commun. 1999 May 19;258(3):657-62.
REF 3 A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Cell. 2015 Oct 22;163(3):712-23.
REF 4 Parkin Modulates Endosomal Organization and Function of the Endo-Lysosomal Pathway. J Neurosci. 2016 Feb 24;36(8):2425-37.
REF 5 Rab-interacting lysosomal protein (RILP): the Rab7 effector required for transport to lysosomes. EMBO J. 2001 Feb 15;20(4):683-93.
REF 6 RILP interacts with HOPS complex via VPS41 subunit to regulate endocytic trafficking. Sci Rep. 2014 Dec 2;4:7282.
REF 7 Crystallization and preliminary X-ray diffraction analysis of monoprenylated Rab7 GTPase in complex with Rab escort protein 1. J Struct Biol. 2003 Jan;141(1):93-5.
REF 8 Moderate discrimination of REP-1 between Rab7 x GDP and Rab7 x GTP arises from a difference of an order of magnitude in dissociation rates. FEBS Lett. 1998 Apr 3;425(3):460-4.

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