Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T12126 Target Info
Target Name Mixed lineage kinase 3 (MAP3K11)
Synonyms Src-homology 3 domain-containing proline-rich kinase; SPRK; SH3 domain-containing proline-rich kinase; Protein-tyrosine kinase PTK1; PTK1; Mixed-lineage protein kinase 3; Mitogen-activated protein kinase kinase kinase 11; MLK3
Target Type Literature-reported Target
Gene Name MAP3K11
Biochemical Class Kinase
UniProt ID
M3K11_HUMAN 
Target Interacting Proteins  Top
Acyltransferases [+] 1 Acyltransferases +
Interacting Target Name TNF receptor-associated factor 6 (TRAF6) Literature-reported Target Interacting Protein Info
UniProt ID
TRAF6_HUMAN 
Synonyms RNF85; RING-type E3 ubiquitin transferase TRAF6; RING finger protein 85; Interleukin-1 signal transducer; E3 ubiquitin-protein ligase TRAF6
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Biochemical Activity [2]
Heat shock proteins [+] 1 Heat shock proteins +
Interacting Target Name Heat shock protein 90 alpha (HSP90A) Successful Target Interacting Protein Info
UniProt ID
HS90A_HUMAN 
Synonyms Renal carcinoma antigen NY-REN-38; LPS-associated protein 2; Lipopolysaccharide-associated protein 2; LAP-2; HSPCA; HSPC1; HSP90A; HSP86; HSP 86; Heat shock protein HSP 90-alpha; Heat shock 86 kDa
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Affinity Capture-Western [3]
3 Affinity Capture-Western [4]
Other proteins [+] 1 Other proteins +
Interacting Target Name JNK-interacting protein 1 peptide (pepJIP1) Patented-recorded Target Interacting Protein Info
UniProt ID
JIP1_HUMAN 
Synonyms PRKM8IP; Mitogen-activated protein kinase 8-interacting protein 1; JNK-interacting protein 1; JNK MAP kinase scaffold protein 1; JIP-1; JIP1; Islet-brain 1; IB-1; IB1; C-Jun-amino-terminal kinase-interacting protein 1
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [5]
2 Affinity Capture-Western [2]
3 Reconstituted Complex [5]
4 Reconstituted Complex [2]
References  Top
REF 1 Cytokine-induced activation of mixed lineage kinase 3 requires TRAF2 and TRAF6. Cell Signal. 2009 Nov;21(11):1620-5.
REF 2 Lysine 63-linked ubiquitination modulates mixed lineage kinase-3 interaction with JIP1 scaffold protein in cytokine-induced pancreatic cell death. J Biol Chem. 2013 Jan 25;288(4):2428-40.
REF 3 Hsp90/p50cdc37 is required for mixed-lineage kinase (MLK) 3 signaling. J Biol Chem. 2004 May 7;279(19):19457-63.
REF 4 The E3 ligase CHIP mediates ubiquitination and degradation of mixed-lineage kinase 3. Mol Cell Biol. 2014 Aug;34(16):3132-43.
REF 5 The JIP group of mitogen-activated protein kinase scaffold proteins. Mol Cell Biol. 1999 Oct;19(10):7245-54.

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