Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T12097 Target Info
Target Name Melanoma-associated antigen 4 (MAGEA4)
Synonyms MAGE4; MAGE-X2 antigen; MAGE-X2; MAGE-41 antigen; MAGE-41; MAGE-4 protein; MAGE-4 antigen; Cancer/testis antigen 1.4; CT1.4
Target Type Clinical trial Target
Gene Name MAGEA4
Biochemical Class Melanoma associated antigen
UniProt ID
MAGA4_HUMAN 
Target Interacting Proteins  Top
Acyltransferases [+] 1 Acyltransferases +
Interacting Protein Name E3 ubiquitin-protein ligase RAD18 (RAD18) Interacting Protein Interacting Protein Info
UniProt ID
RAD18_HUMAN 
Synonyms RNF73
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Reconstituted Complex [3]
Transcription regulators [+] 1 Transcription regulators +
Interacting Protein Name Tigger transposable element-derived protein 5 (TIGD5) Interacting Protein Interacting Protein Info
UniProt ID
TIGD5_HUMAN 
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Yeast two hybrid [4]
Other proteins [+] 2 Other proteins +
Interacting Protein Name Cytochrome b-c1 complex subunit 7 (UQCRB) Interacting Protein Interacting Protein Info
UniProt ID
QCR7_HUMAN 
Synonyms MC3DN3; QCR7; QP.C; QPC; UQBC; UQBP; UQCR6; UQPC
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Yeast two hybrid [5]
4 Yeast two hybrid [4]
Interacting Target Name Angiomotin (AMOT) Literature-reported Target Interacting Protein Info
UniProt ID
AMOT_HUMAN 
Synonyms KIAA1071
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Yeast two hybrid [4]
References  Top
REF 1 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 2 The BioPlex Network: A Systematic Exploration of the Human Interactome. Cell. 2015 Jul 16;162(2):425-440.
REF 3 A neomorphic cancer cell-specific role of MAGE-A4 in trans-lesion synthesis. Nat Commun. 2016 Jul 5;7:12105.
REF 4 A proteome-scale map of the human interactome network. Cell. 2014 Nov 20;159(5):1212-1226.
REF 5 Towards a proteome-scale map of the human protein-protein interaction network. Nature. 2005 Oct 20;437(7062):1173-8.

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