Target Interacting Protein Information
Target General Information | Top | ||||
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Target ID | T08741 | Target Info | |||
Target Name | Tyrosine-protein kinase CSK (CSK) | ||||
Synonyms | Protein-tyrosine kinase CYL; C-Src kinase | ||||
Target Type | Patented-recorded Target | ||||
Gene Name | CSK | ||||
Biochemical Class | Kinase | ||||
UniProt ID |
Target Interacting Proteins | Top | ||||
---|---|---|---|---|---|
Acyltransferases | [+] 1 Acyltransferases | + | |||
Interacting Target Name | Signal transduction protein CBL (CBL) | Literature-reported Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | RNF55; RING-type E3 ubiquitin transferase CBL; RING finger protein 55; Proto-oncogene c-CBL; E3 ubiquitin-protein ligase CBL; C-Cbl; CBL2; Casitas B-lineage lymphoma proto-oncogene | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [1] | |||
2 | Affinity Capture-Western | [2] | |||
Auxiliary transporters | [+] 1 Auxiliary transporters | + | |||
Interacting Target Name | Caveolin 1 (CAV1) | Literature-reported Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | Caveolin-1; Caveolin1; Cav-1; CAV | ||||
Evidence Score (E-score) | 3 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [3] | |||
2 | Reconstituted Complex | [3] | |||
3 | Yeast two hybrid | [4] | |||
Kinases | [+] 2 Kinases | + | |||
Interacting Target Name | Epidermal growth factor receptor (EGFR) | Successful Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | Epidermal growth factor receptor variant III; Proto-oncogene c-ErbB-1 variant III; Receptor tyrosine-protein kinase erbB-1 variant III; EGFR variant III; ERBB variant III; ERBB1 variant III; HER1 variant III | ||||
Evidence Score (E-score) | 4 Experimental Evidences | + | |||
1 | Affinity Capture-Luminescence | [5] | |||
2 | Affinity Capture-MS | [6] | |||
3 | Protein-Fragment Complementation Assay | [5] | |||
4 | Yeast two hybrid | [7] | |||
Interacting Target Name | RAC-alpha serine/threonine-protein kinase (AKT1) | Successful Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | RAC-PK-alpha; RAC; Proto-oncogene c-Akt; Protein kinase B alpha; Protein kinase B; PKB alpha; PKB | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [8] | |||
2 | Co-fractionation | [9] | |||
Other proteins | [+] 1 Other proteins | + | |||
Interacting Protein Name | Transmembrane adapter protein PAG (PAG1) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | CBP; PAG | ||||
Evidence Score (E-score) | 3 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [10] | |||
2 | Affinity Capture-Western | [11] | |||
3 | Reconstituted Complex | [12] |
References | Top | ||||
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REF 1 | Charting the molecular network of the drug target Bcr-Abl. Proc Natl Acad Sci U S A. 2009 May 5;106(18):7414-9. | ||||
REF 2 | Cbl associates with Pyk2 and Src to regulate Src kinase activity, alpha(v)beta(3) integrin-mediated signaling, cell adhesion, and osteoclast motility. J Cell Biol. 2001 Jan 8;152(1):181-95. | ||||
REF 3 | SHP-2 binds to caveolin-1 and regulates Src activity via competitive inhibition of CSK in response to H2O2 in astrocytes. PLoS One. 2014 Mar 14;9(3):e91582. | ||||
REF 4 | A phosphotyrosine-dependent protein interaction screen reveals a role for phosphorylation of caveolin-1 on tyrosine 14: recruitment of C-terminal Src kinase. J Biol Chem. 2002 Mar 15;277(11):8771-4. | ||||
REF 5 | The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells. Nat Methods. 2014 May;11(5):585-92. | ||||
REF 6 | Phosphotyrosine interactome of the ErbB-receptor kinase family. Mol Syst Biol. 2005;1:2005.0008. | ||||
REF 7 | In silico prediction of physical protein interactions and characterization of interactome orphans. Nat Methods. 2015 Jan;12(1):79-84. | ||||
REF 8 | c-Src regulates Akt signaling in response to ghrelin via beta-arrestin signaling-independent and -dependent mechanisms. PLoS One. 2009;4(3):e4686. | ||||
REF 9 | Panorama of ancient metazoan macromolecular complexes. Nature. 2015 Sep 17;525(7569):339-44. | ||||
REF 10 | Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509. | ||||
REF 11 | Combined spatial and enzymatic regulation of Csk by cAMP and protein kinase a inhibits T cell receptor signaling. J Biol Chem. 2003 May 16;278(20):17597-600. | ||||
REF 12 | Phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG), a novel ubiquitously expressed transmembrane adaptor protein, binds the protein tyrosine kinase csk and is involved in regulation of T cell activation. J Exp Med. 2000 May 1;191(9):1591-604. |
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