Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T06421 Target Info
Target Name Interferon alpha/beta receptor 2 (IFNAR2)
Synonyms Type I interferon receptor 2; Type I interferon receptor; Interferon alpha/beta receptor; Interferon alpha binding protein; IFNARB; IFNABR; IFN-alpha/beta receptor 2; IFN-alpha-REC; IFN-alpha binding protein; IFN-R-2; IFN-R
Target Type Successful Target
Gene Name IFNAR2
Biochemical Class Cytokine receptor
UniProt ID
INAR2_HUMAN 
Target Interacting Proteins  Top
Auxiliary transporters [+] 2 Auxiliary transporters +
Interacting Target Name Receptor of activated protein C kinase 1 (RACK1) Literature-reported Target Interacting Protein Info
UniProt ID
RACK1_HUMAN 
Synonyms Small ribosomal subunit protein RACK1; Receptor of activated protein C kinase 1, N-terminally processed; Receptor for activated C kinase; Human lung cancer oncogene 7 protein; HLC-7; Guanine nucleotide-binding protein subunit beta-like protein 12.3; Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed; Guanine nucleotide-binding protein subunit beta-2-like 1; GNB2L1; Cell proliferation-inducing gene 21 protein
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Reconstituted Complex [2]
3 Reconstituted Complex [1]
4 Yeast two hybrid [1]
Interacting Target Name Interferon alpha/beta receptor 1 (IFNAR1) Clinical trial Target Interacting Protein Info
UniProt ID
INAR1_HUMAN 
Synonyms Type I interferon receptor 1; IFN-R-1; IFNR1; IFNAR; IFN-alpha/beta receptor 1; IFNalpha/beta receptor 1; Cytokine receptor family 2 member 1; Cytokine receptor class-II member 1; Cytokine receptor classII member 1; CRF2-1; CRF21
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Co-localization [4]
Kinases [+] 1 Kinases +
Interacting Target Name Janus kinase 1 (JAK-1) Successful Target Interacting Protein Info
UniProt ID
JAK1_HUMAN 
Synonyms Tyrosine-protein kinase JAK1; JAK1B; JAK1A
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [5]
2 Reconstituted Complex [6]
Peptidases [+] 1 Peptidases +
Interacting Protein Name Ubl carboxyl-terminal hydrolase 18 (USP18) Interacting Protein Interacting Protein Info
UniProt ID
UBP18_HUMAN 
Synonyms ISG43; UBP43
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [5]
2 Affinity Capture-Western [7]
3 Affinity Capture-Western [8]
4 Co-localization [7]
Transcription regulators [+] 1 Transcription regulators +
Interacting Protein Name Signal transducer and activator of transcription 2 (STAT2) Interacting Protein Interacting Protein Info
UniProt ID
STAT2_HUMAN 
Synonyms ISGF.3; P113; STAT113
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-Western [9]
2 Affinity Capture-Western [10]
3 Affinity Capture-Western [7]
4 Co-localization [7]
5 Reconstituted Complex [11]
6 Reconstituted Complex [9]
References  Top
REF 1 Receptor for activated C-kinase (RACK-1), a WD motif-containing protein, specifically associates with the human type I IFN receptor. J Immunol. 2000 Nov 1;165(9):5127-32.
REF 2 The WD motif-containing protein receptor for activated protein kinase C (RACK1) is required for recruitment and activation of signal transducer and activator of transcription 1 through the type I interferon receptor. J Biol Chem. 2001 Jun 22;276(25):22948-53.
REF 3 A BRISC-SHMT complex deubiquitinates IFNAR1 and regulates interferon responses. Cell Rep. 2013 Oct 17;5(1):180-93.
REF 4 Receptor dimerization dynamics as a regulatory valve for plasticity of type I interferon signaling. J Cell Biol. 2015 May 25;209(4):579-93.
REF 5 UBP43 is a novel regulator of interferon signaling independent of its ISG15 isopeptidase activity. EMBO J. 2006 Jun 7;25(11):2358-67.
REF 6 Two distinct domains within the N-terminal region of Janus kinase 1 interact with cytokine receptors. J Immunol. 2002 Aug 1;169(3):1302-8.
REF 7 STAT2 is an essential adaptor in USP18-mediated suppression of type I interferon signaling. Nat Struct Mol Biol. 2017 Mar;24(3):279-289.
REF 8 Acetaldehyde Disrupts Interferon Alpha Signaling in Hepatitis C Virus-Infected Liver Cells by Up-Regulating USP18. Alcohol Clin Exp Res. 2016 Nov;40(11):2329-2338.
REF 9 Stat2 binding to the interferon-alpha receptor 2 subunit is not required for interferon-alpha signaling. J Biol Chem. 2002 Mar 22;277(12):9713-21.
REF 10 Acetylation-dependent signal transduction for type I interferon receptor. Cell. 2007 Oct 5;131(1):93-105.
REF 11 Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signaling. Mol Cell Biol. 1997 Apr;17(4):2048-56.

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