Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T04364 Target Info
Target Name Cullin-3 (CUL-3)
Synonyms KIAA0617; Cullin3
Target Type Literature-reported Target
Gene Name CUL3
UniProt ID
CUL3_HUMAN 
Target Interacting Proteins  Top
Acid anhydride hydrolases [+] 4 Acid anhydride hydrolases +
Interacting Protein Name Rho-related BTB domain-containing protein 1 (RHOBTB1) Interacting Protein Interacting Protein Info
UniProt ID
RHBT1_HUMAN 
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [2]
3 Affinity Capture-Western [3]
4 Affinity Capture-Western [4]
Interacting Protein Name Rho-related BTB domain-containing protein 3 (RHOBTB3) Interacting Protein Interacting Protein Info
UniProt ID
RHBT3_HUMAN 
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [5]
3 Affinity Capture-Western [2]
4 Affinity Capture-Western [6]
Interacting Protein Name Rho-related BTB domain-containing protein 2 (RHOBTB2) Interacting Protein Interacting Protein Info
UniProt ID
RHBT2_HUMAN 
Synonyms DBC2
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [7]
3 Affinity Capture-Western [2]
Interacting Target Name Valosin-containing protein p97 (VCP) Clinical trial Target Interacting Protein Info
UniProt ID
TERA_HUMAN 
Synonyms Valosin-containing protein; Transitional endoplasmic reticulum ATPase; TER ATPase; 15S Mg(2+)-ATPase p97 subunit
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [8]
Acyltransferases [+] 2 Acyltransferases +
Interacting Protein Name E3 ubiquitin-protein ligase RBX1 (RBX1) Interacting Protein Interacting Protein Info
UniProt ID
RBX1_HUMAN 
Synonyms BA554C12.1; RNF75; ROC1
Evidence Score (E-score) 12 Experimental Evidences +
1 Affinity Capture-MS [9]
2 Affinity Capture-Western [10]
3 Affinity Capture-Western [11]
4 Affinity Capture-Western [3]
5 Affinity Capture-Western [12]
6 Affinity Capture-Western [13]
7 Affinity Capture-Western [14]
8 Affinity Capture-Western [15]
9 Affinity Capture-Western [16]
10 Affinity Capture-Western [17]
11 Affinity Capture-Western [6]
12 Reconstituted Complex [18]
Interacting Target Name ATP-citrate synthase (ACLY) Successful Target Interacting Protein Info
UniProt ID
ACLY_HUMAN 
Synonyms Citrate cleavageenzyme; Citrate cleavage enzyme; ATP-citrate lyase; ATP-citrate (pro-S-)-lyase; Acly; ACL
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [19]
Adapter proteins [+] 6 Adapter proteins +
Interacting Protein Name Kelch-like protein 3 (KLHL3) Interacting Protein Interacting Protein Info
UniProt ID
KLHL3_HUMAN 
Synonyms PHA2D
Evidence Score (E-score) 7 Experimental Evidences +
1 Affinity Capture-Western [20]
2 Affinity Capture-Western [9]
3 Affinity Capture-Western [3]
4 Affinity Capture-Western [21]
5 Affinity Capture-Western [22]
6 Reconstituted Complex [23]
7 Yeast two hybrid [24]
Interacting Protein Name Kelch-like protein 22 (KLHL22) Interacting Protein Interacting Protein Info
UniProt ID
KLH22_HUMAN 
Synonyms KELCHL
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [25]
2 Affinity Capture-MS [5]
3 Affinity Capture-MS [1]
4 Affinity Capture-MS [26]
5 Affinity Capture-Western [27]
Interacting Protein Name Kelch-like protein 25 (KLHL25) Interacting Protein Interacting Protein Info
UniProt ID
KLH25_HUMAN 
Synonyms ENC.2; ENC2
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [5]
3 Affinity Capture-Western [28]
4 Affinity Capture-Western [19]
Interacting Protein Name Kelch-like protein 20 (KLHL20) Interacting Protein Interacting Protein Info
UniProt ID
KLH20_HUMAN 
Synonyms KHLHX; KLEIP; KLHLX
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Reconstituted Complex [29]
3 Reconstituted Complex [30]
Interacting Protein Name Kelch-like protein 21 (KLHL21) Interacting Protein Interacting Protein Info
UniProt ID
KLH21_HUMAN 
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [5]
3 Affinity Capture-Western [27]
Interacting Target Name Sequestosome-1 p62 (SQSTM1) Literature-reported Target Interacting Protein Info
UniProt ID
SQSTM_HUMAN 
Synonyms Ubiquitin-binding protein p62; Sequestosome-1; Phosphotyrosine-independent ligand for the Lck SH2 domain of 62kDa; Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa; OSIL; ORCA; EBIAP; EBI3-associated protein of 60 kDa
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [31]
2 Co-localization [32]
Cell cycle related proteins [+] 1 Cell cycle related proteins +
Interacting Target Name G1/S-specific cyclin-E1 (CCNE1) Literature-reported Target Interacting Protein Info
UniProt ID
CCNE1_HUMAN 
Synonyms G1/S-specific cyclin E; Cyclin E; CCNE
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [33]
2 Affinity Capture-Western [34]
3 Affinity Capture-Western [33]
COP9 signalosomes [+] 2 COP9 signalosomes +
Interacting Protein Name COP9 signalosome complex subunit 2 (COPS2) Interacting Protein Interacting Protein Info
UniProt ID
CSN2_HUMAN 
Synonyms ALIEN; CSN2; SGN2; TRIP15
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [26]
3 Reconstituted Complex [35]
Interacting Protein Name COP9 signalosome complex subunit 8 (COPS8) Interacting Protein Interacting Protein Info
UniProt ID
CSN8_HUMAN 
Synonyms COP9; CSN8; SGN8
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [9]
Cullins [+] 1 Cullins +
Interacting Protein Name Cullin-1 (CUL1) Interacting Protein Interacting Protein Info
UniProt ID
CUL1_HUMAN 
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Co-fractionation [36]
Heat shock proteins [+] 1 Heat shock proteins +
Interacting Protein Name Heat shock 70 kDa protein 4 (HSPA4) Interacting Protein Interacting Protein Info
UniProt ID
HSP74_HUMAN 
Synonyms APG.2; HEL.S.5a; HS24/P52; HSPH2; RY; hsp70; hsp70RY
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [13]
Isomerases [+] 2 Isomerases +
Interacting Target Name Mitochondrial matrix protein P1 (HSPD1) Clinical trial Target Interacting Protein Info
UniProt ID
CH60_HUMAN 
Synonyms P60 lymphocyte protein; HuCHA60; HSP-60; Hsp60; Heat shock protein 60; CPN60; Chaperonin 60; 60 kDa heat shock protein, mitochondrial; 60 kDa chaperonin
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [13]
Interacting Protein Name Katanin p60 ATPase-containing subunit A1 (KATNA1) Interacting Protein Interacting Protein Info
UniProt ID
KTNA1_HUMAN 
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [37]
2 Co-fractionation [36]
Membrane-bounded channels [+] 1 Membrane-bounded channels +
Interacting Protein Name Nuclear pore complex protein Nup50 (NUP50) Interacting Protein Interacting Protein Info
UniProt ID
NUP50_HUMAN 
Synonyms NPAP60; NPAP60L
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Co-fractionation [36]
Peptidases [+] 1 Peptidases +
Interacting Target Name JUN activation domain binding protein (COPS5) Literature-reported Target Interacting Protein Info
UniProt ID
CSN5_HUMAN 
Synonyms Signalosome subunit 5; SGN5; Jun activation domain-binding protein 1; JAB1; CSN5; COP9 signalosome complex subunit 5
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [26]
3 Affinity Capture-Western [1]
4 Affinity Capture-Western [38]
Ubiquitin related proteins [+] 4 Ubiquitin related proteins +
Interacting Protein Name BTB/POZ domain-containing protein KCTD10 (KCTD10) Interacting Protein Interacting Protein Info
UniProt ID
BACD3_HUMAN 
Synonyms BTBD28; ULRO61; hBACURD3
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [5]
3 Affinity Capture-MS [26]
4 Affinity Capture-MS [39]
5 Affinity Capture-Western [40]
6 Reconstituted Complex [41]
Interacting Protein Name BTB/POZ domain-containing protein KCTD13 (KCTD13) Interacting Protein Interacting Protein Info
UniProt ID
BACD1_HUMAN 
Synonyms BACURD1; PDIP1; POLDIP1; hBACURD1
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [42]
3 Affinity Capture-Western [3]
4 Reconstituted Complex [41]
5 Yeast two hybrid [24]
Interacting Target Name Polyubiquitin-C (UBC) Patented-recorded Target Interacting Protein Info
UniProt ID
UBC_HUMAN 
Synonyms HMG20; ubiquitin C
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [26]
3 Biochemical Activity [43]
Interacting Protein Name BTB/POZ domain-containing protein TNFAIP1 (TNFAIP1) Interacting Protein Interacting Protein Info
UniProt ID
BACD2_HUMAN 
Synonyms B12; B61; BTBD34; EDP1; hBACURD2
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [5]
3 Affinity Capture-Western [42]
Other proteins [+] 31 Other proteins +
Interacting Protein Name Cullin-associated NEDD8-dissociated protein 1 (CAND1) Interacting Protein Interacting Protein Info
UniProt ID
CAND1_HUMAN 
Synonyms TIP120; TIP120A
Evidence Score (E-score) 7 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [44]
3 Affinity Capture-Western [38]
4 Affinity Capture-Western [45]
5 Affinity Capture-Western [11]
6 Affinity Capture-Western [9]
7 Affinity Capture-Western [46]
Interacting Protein Name Kelch-like protein 12 (KLHL12) Interacting Protein Interacting Protein Info
UniProt ID
KLH12_HUMAN 
Synonyms C3IP1; DKIR
Evidence Score (E-score) 7 Experimental Evidences +
1 Affinity Capture-MS [25]
2 Affinity Capture-MS [1]
3 Affinity Capture-MS [26]
4 Affinity Capture-Western [47]
5 Affinity Capture-Western [48]
6 Reconstituted Complex [49]
7 Yeast two hybrid [24]
Interacting Protein Name Kelch-like protein 42 (KLHL42) Interacting Protein Interacting Protein Info
UniProt ID
KLH42_HUMAN 
Synonyms Ctb9; KLHDC5
Evidence Score (E-score) 7 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [5]
3 Affinity Capture-MS [26]
4 Affinity Capture-MS [50]
5 Affinity Capture-Western [37]
6 Reconstituted Complex [51]
7 Yeast two hybrid [37]
Interacting Protein Name Speckle-type POZ protein (SPOP) Interacting Protein Interacting Protein Info
UniProt ID
SPOP_HUMAN 
Synonyms BTBD32; TEF2
Evidence Score (E-score) 7 Experimental Evidences +
1 Affinity Capture-MS [50]
2 Affinity Capture-Western [52]
3 Affinity Capture-Western [38]
4 Affinity Capture-Western [53]
5 Reconstituted Complex [51]
6 Yeast two hybrid [37]
7 Yeast two hybrid [54]
Interacting Protein Name BTB/POZ domain-containing protein 1 (BTBD1) Interacting Protein Interacting Protein Info
UniProt ID
BTBD1_HUMAN 
Synonyms C15orf1; NS5ATP8
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [25]
2 Affinity Capture-MS [1]
3 Affinity Capture-MS [26]
4 Affinity Capture-Western [50]
5 Affinity Capture-Western [27]
Interacting Protein Name BTB/POZ domain-containing protein KCTD6 (KCTD6) Interacting Protein Interacting Protein Info
UniProt ID
KCTD6_HUMAN 
Synonyms KCASH3
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [5]
3 Affinity Capture-Western [55]
4 Reconstituted Complex [56]
5 Yeast two hybrid [24]
Interacting Protein Name BTB/POZ domain-containing protein 2 (BTBD2) Interacting Protein Interacting Protein Info
UniProt ID
BTBD2_HUMAN 
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [25]
2 Affinity Capture-MS [1]
3 Affinity Capture-MS [26]
4 Affinity Capture-Western [27]
Interacting Protein Name DCN1-like protein 1 (DCUN1D1) Interacting Protein Interacting Protein Info
UniProt ID
DCNL1_HUMAN 
Synonyms DCNL1; DCUN1L1; RP42; SCCRO; SCRO; Tes3
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [5]
3 Co-fractionation [36]
4 Reconstituted Complex [12]
Interacting Protein Name Kelch repeat and BTB domain-containing protein 6 (KBTBD6) Interacting Protein Interacting Protein Info
UniProt ID
KBTB6_HUMAN 
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [5]
3 Affinity Capture-MS [26]
4 Affinity Capture-Western [57]
Interacting Protein Name BTB/POZ domain-containing protein KCTD17 (KCTD17) Interacting Protein Interacting Protein Info
UniProt ID
KCD17_HUMAN 
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [14]
3 Reconstituted Complex [56]
4 Reconstituted Complex [41]
Interacting Protein Name BTB/POZ domain-containing protein KCTD5 (KCTD5) Interacting Protein Interacting Protein Info
UniProt ID
KCTD5_HUMAN 
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Reconstituted Complex [58]
3 Reconstituted Complex [41]
4 Reconstituted Complex [56]
Interacting Protein Name Kelch-like protein 13 (KLHL13) Interacting Protein Interacting Protein Info
UniProt ID
KLH13_HUMAN 
Synonyms BKLHD2
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [25]
2 Affinity Capture-MS [1]
3 Affinity Capture-MS [26]
4 Affinity Capture-Western [27]
Interacting Protein Name Kelch-like protein 2 (KLHL2) Interacting Protein Interacting Protein Info
UniProt ID
KLHL2_HUMAN 
Synonyms ABP.KELCH; MAV; MAYVEN
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [5]
3 Affinity Capture-Western [21]
4 Yeast two hybrid [24]
Interacting Protein Name Kelch-like protein 9 (KLHL9) Interacting Protein Interacting Protein Info
UniProt ID
KLHL9_HUMAN 
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [25]
2 Affinity Capture-MS [1]
3 Affinity Capture-MS [26]
4 Affinity Capture-Western [27]
Interacting Protein Name Inhibitor of Bruton tyrosine kinase (IBTK) Interacting Protein Interacting Protein Info
UniProt ID
IBTK_HUMAN 
Synonyms BTBD26; BTKI
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [5]
3 Affinity Capture-Western [59]
Interacting Protein Name Kelch repeat and BTB domain-containing protein 7 (KBTBD7) Interacting Protein Interacting Protein Info
UniProt ID
KBTB7_HUMAN 
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [5]
3 Affinity Capture-Western [57]
Interacting Protein Name BTB/POZ domain-containing protein KCTD2 (KCTD2) Interacting Protein Interacting Protein Info
UniProt ID
KCTD2_HUMAN 
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [5]
3 Yeast two hybrid [60]
Interacting Protein Name BTB/POZ domain-containing protein KCTD9 (KCTD9) Interacting Protein Interacting Protein Info
UniProt ID
KCTD9_HUMAN 
Synonyms BTBD27
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Reconstituted Complex [56]
3 Yeast two hybrid [24]
Interacting Protein Name Kelch-like protein 15 (KLHL15) Interacting Protein Interacting Protein Info
UniProt ID
KLH15_HUMAN 
Synonyms HEL.S.305
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [5]
3 Affinity Capture-Western [61]
Interacting Protein Name Kelch-like protein 18 (KLHL18) Interacting Protein Interacting Protein Info
UniProt ID
KLH18_HUMAN 
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [26]
3 Affinity Capture-Western [62]
Interacting Protein Name SH3KBP1-binding protein 1 (SHKBP1) Interacting Protein Interacting Protein Info
UniProt ID
SHKB1_HUMAN 
Synonyms Sb1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Reconstituted Complex [41]
3 Yeast two hybrid [54]
Interacting Protein Name Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1) Interacting Protein Interacting Protein Info
UniProt ID
ABTB1_HUMAN 
Synonyms BPOZ; BTB3; BTBD21; EF1ABP
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Yeast two hybrid [24]
Interacting Protein Name Elongin-C (ELOC) Interacting Protein Interacting Protein Info
UniProt ID
ELOC_HUMAN 
Synonyms SIII; eloC
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Yeast two hybrid [54]
Interacting Protein Name Golgi resident protein GCP60 (ACBD3) Interacting Protein Interacting Protein Info
UniProt ID
GCP60_HUMAN 
Synonyms GCP60; GOCAP1; GOLPH1; PAP7
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Co-fractionation [63]
Interacting Protein Name Germ cell-less protein-like 1 (GMCL1) Interacting Protein Interacting Protein Info
UniProt ID
GMCL1_HUMAN 
Synonyms BTBD13; GCL; GCL1; SPATA29
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Yeast two hybrid [24]
Interacting Protein Name BTB/POZ domain-containing protein KCTD7 (KCTD7) Interacting Protein Interacting Protein Info
UniProt ID
KCTD7_HUMAN 
Synonyms CLN14; EPM3
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [64]
Interacting Protein Name Kelch-like protein 5 (KLHL5) Interacting Protein Interacting Protein Info
UniProt ID
KLHL5_HUMAN 
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Yeast two hybrid [54]
Interacting Protein Name Peflin (PEF1) Interacting Protein Interacting Protein Info
UniProt ID
PEF1_HUMAN 
Synonyms ABP32; PEF1A
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Reconstituted Complex [49]
Interacting Protein Name RNA-binding protein 45 (RBM45) Interacting Protein Interacting Protein Info
UniProt ID
RBM45_HUMAN 
Synonyms DRB1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [65]
Interacting Protein Name RCC1 and BTB domain-containing protein 1 (RCBTB1) Interacting Protein Interacting Protein Info
UniProt ID
RCBT1_HUMAN 
Synonyms CLLD7; CLLL7; GLP
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Reconstituted Complex [51]
Interacting Protein Name Splicing factor 3B subunit 3 (SF3B3) Interacting Protein Interacting Protein Info
UniProt ID
SF3B3_HUMAN 
Synonyms RSE1; SAP130; SF3b130; STAF130
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [66]
References  Top
REF 1 Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. Cell. 2010 Dec 10;143(6):951-65.
REF 2 Characterization of RhoBTB-dependent Cul3 ubiquitin ligase complexes--evidence for an autoregulatory mechanism. Exp Cell Res. 2008 Nov 15;314(19):3453-65.
REF 3 Hypertension-causing Mutations in Cullin3 Protein Impair RhoA Protein Ubiquitination and Augment the Association with Substrate Adaptors. J Biol Chem. 2015 Jul 31;290(31):19208-17.
REF 4 Cullin-3 regulates vascular smooth muscle function and arterial blood pressure via PPAR and RhoA/Rho-kinase. Cell Metab. 2012 Oct 3;16(4):462-72.
REF 5 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 6 Golgi-associated RhoBTB3 targets cyclin E for ubiquitylation and promotes cell cycle progression. J Cell Biol. 2013 Oct 28;203(2):233-50.
REF 7 RhoBTB2 is a substrate of the mammalian Cul3 ubiquitin ligase complex. Genes Dev. 2004 Apr 15;18(8):856-61.
REF 8 NEDD8 links cullin-RING ubiquitin ligase function to the p97 pathway. Nat Struct Mol Biol. 2012 Apr 1;19(5):511-6, S1.
REF 9 Characterisation of the Cullin-3 mutation that causes a severe form of familial hypertension and hyperkalaemia. EMBO Mol Med. 2015 Oct;7(10):1285-306.
REF 10 Activation of UBC5 ubiquitin-conjugating enzyme by the RING finger of ROC1 and assembly of active ubiquitin ligases by all cullins. J Biol Chem. 2002 May 3;277(18):15758-65.
REF 11 The glomuvenous malformation protein Glomulin binds Rbx1 and regulates cullin RING ligase-mediated turnover of Fbw7. Mol Cell. 2012 Apr 13;46(1):67-78.
REF 12 The human Dcn1-like protein DCNL3 promotes Cul3 neddylation at membranes. Proc Natl Acad Sci U S A. 2009 Jul 28;106(30):12365-70.
REF 13 Preferential interaction of TIP120A with Cul1 that is not modified by NEDD8 and not associated with Skp1. Biochem Biophys Res Commun. 2003 Apr 18;303(4):1209-16.
REF 14 Ubiquitin-proteasome system controls ciliogenesis at the initial step of axoneme extension. Nat Commun. 2014 Oct 1;5:5081.
REF 15 BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligase. Mol Cell Biol. 2005 Jan;25(1):162-71.
REF 16 Dihydro-CDDO-trifluoroethyl amide (dh404), a novel Nrf2 activator, suppresses oxidative stress in cardiomyocytes. PLoS One. 2009 Dec 21;4(12):e8391.
REF 17 KEAP1 E3 ligase-mediated downregulation of NF-kappaB signaling by targeting IKKbeta. Mol Cell. 2009 Oct 9;36(1):131-40.
REF 18 Prostate cancer. Ubiquitylome analysis identifies dysregulation of effector substrates in SPOP-mutant prostate cancer. Science. 2014 Oct 3;346(6205):85-89.
REF 19 Cullin3-KLHL25 ubiquitin ligase targets ACLY for degradation to inhibit lipid synthesis and tumor progression. Genes Dev. 2016 Sep 1;30(17):1956-70.
REF 20 Impaired KLHL3-mediated ubiquitination of WNK4 causes human hypertension. Cell Rep. 2013 Mar 28;3(3):858-68.
REF 21 KLHL2 interacts with and ubiquitinates WNK kinases. Biochem Biophys Res Commun. 2013 Aug 2;437(3):457-62.
REF 22 Hyperkalemic hypertension-associated cullin 3 promotes WNK signaling by degrading KLHL3. J Clin Invest. 2014 Nov;124(11):4723-36.
REF 23 Disease-causing mutations in KLHL3 impair its effect on WNK4 degradation. FEBS Lett. 2013 Jun 19;587(12):1717-22.
REF 24 A proteome-scale map of the human interactome network. Cell. 2014 Nov 20;159(5):1212-1226.
REF 25 A Cul3-based E3 ligase removes Aurora B from mitotic chromosomes, regulating mitotic progression and completion of cytokinesis in human cells. Dev Cell. 2007 Jun;12(6):887-900.
REF 26 An interaction network of the mammalian COP9 signalosome identifies Dda1 as a core subunit of multiple Cul4-based E3 ligases. J Cell Sci. 2009 Apr 1;122(Pt 7):1035-44.
REF 27 The Cul3-KLHL21 E3 ubiquitin ligase targets aurora B to midzone microtubules in anaphase and is required for cytokinesis. J Cell Biol. 2009 Dec 14;187(6):791-800.
REF 28 Translational homeostasis via the mRNA cap-binding protein, eIF4E. Mol Cell. 2012 Jun 29;46(6):847-58.
REF 29 K33-Linked Polyubiquitination of Coronin 7 by Cul3-KLHL20biquitin E3 Ligase Regulates Protein Trafficking. Mol Cell. 2014 May 22;54(4):586-600.
REF 30 KLHL39 suppresses colon cancer metastasis by blocking KLHL20-mediated PML and DAPK ubiquitination. Oncogene. 2015 Oct 1;34(40):5141-51.
REF 31 Involvement of selective autophagy mediated by p62/SQSTM1n KLHL3-dependent WNK4 degradation. Biochem J. 2015 Nov 15;472(1):33-41.
REF 32 A noncanonical mechanism of Nrf2 activation by autophagy deficiency: direct interaction between Keap1 and p62. Mol Cell Biol. 2010 Jul;30(13):3275-85.
REF 33 The ID1-CULLIN3 Axis Regulates Intracellular SHH and WNT Signaling in Glioblastoma Stem Cells. Cell Rep. 2016 Aug 9;16(6):1629-1641.
REF 34 Cullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian cells. Genes Dev. 1999 Sep 15;13(18):2375-87.
REF 35 Inositol hexakisphosphate (IP6) generated by IP5K mediates cullin-COP9 signalosome interactions and CRL function. Proc Natl Acad Sci U S A. 2016 Mar 29;113(13):3503-8.
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