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| Target General Information |
Top |
| Target ID |
T02446 |
Target Info
|
| Target Name |
Ephrin type-B receptor 1 (EPHB1) |
| Synonyms |
hEK6; Tyrosine-protein kinase receptor EPH-2; Neuronally-expressed EPH-related tyrosine kinase; EPHT2; EPH-like kinase 6; EPH tyrosine kinase 2; ELK; EK6 |
| Target Type |
Literature-reported Target |
| Gene Name |
EPHB1 |
| Biochemical Class |
Kinase |
| UniProt ID |
|
| Target Interacting Proteins |
Top |
| Acyltransferases |
[+] 1 Acyltransferases |
+ |
| Interacting Target Name |
Signal transduction protein CBL (CBL) |
Literature-reported Target |
Interacting Protein Info
|
| UniProt ID |
|
| Synonyms |
RNF55; RING-type E3 ubiquitin transferase CBL; RING finger protein 55; Proto-oncogene c-CBL; E3 ubiquitin-protein ligase CBL; C-Cbl; CBL2; Casitas B-lineage lymphoma proto-oncogene |
| Evidence Score (E-score) |
3 Experimental Evidences |
+ |
| 1 |
Affinity Capture-Western |
[1] |
| 2 |
Affinity Capture-Western |
[2] |
| 3 |
Co-localization |
[1] |
| References |
Top |
| REF 1 |
Ligand binding induces Cbl-dependent EphB1 receptor degradation through the lysosomal pathway. Traffic. 2008 Feb;9(2):251-66.
|
| REF 2 |
Phosphatase and tensin homolog regulates stability and activity of EphB1 receptor. FASEB J. 2013 Feb;27(2):632-44.
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