Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T02333 Target Info
Target Name Growth hormone receptor (GHR)
Synonyms Somatotropin receptor; Serum bindingprotein; GH receptor
Target Type Successful Target
Gene Name GHR
Biochemical Class Cytokine receptor
UniProt ID
GHR_HUMAN 
Target Interacting Proteins  Top
Kinases [+] 1 Kinases +
Interacting Target Name Janus kinase 2 (JAK-2) Successful Target Interacting Protein Info
UniProt ID
JAK2_HUMAN 
Synonyms Tyrosine-protein kinase JAK2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Co-fractionation [2]
Other proteins [+] 1 Other proteins +
Interacting Target Name Somatotropin (GH1) Clinical trial Target Interacting Protein Info
UniProt ID
SOMA_HUMAN 
Synonyms Pituitary growth hormone; Growth hormone 1; Growth hormone; GH-N; GH
Evidence Score (E-score) 2 Experimental Evidences +
1 Co-purification [2]
2 Reconstituted Complex [3]
References  Top
REF 1 Regions of the JAK2 tyrosine kinase required for coupling to the growth hormone receptor. J Biol Chem. 1995 Jun 16;270(24):14776-85.
REF 2 Multimeric growth hormone receptor complexes serve as signaling platforms. J Biol Chem. 2014 Jan 3;289(1):65-73.
REF 3 A single arginine residue determines species specificity of the human growth hormone receptor. Proc Natl Acad Sci U S A. 1995 Feb 14;92(4):959-63.

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