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| Target General Information |
Top |
| Target ID |
T92803 |
Target Info
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| Target Name |
Dual-specificity tyrosine-phosphorylation regulated kinase 1A (DYRK1A) |
| Synonyms |
hMNB; Protein kinase minibrain homolog; MNBH; MNB; HP86; Dual specificity tyrosine-phosphorylation-regulated kinase 1A; Dual specificity YAK1-related kinase; DYRK |
| Target Type |
Patented-recorded Target |
| Gene Name |
DYRK1A |
| Biochemical Class |
Kinase |
| UniProt ID |
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| The microRNAs (miRNAs) Regulating This Target |
Top |
| miRNA Mature ID |
hsa-miR-1246 |
miRNA Info
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| miRNA Mature AC |
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| Sequence |
aauggauuuuuggagcagg
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| miRNA Species |
Homo sapiens |
| Regulation Mechanism |
DYRK1A, which is a target of miR-1246, were suppressed by treatment with SAHA and DzNep, leading to apoptosis, cell cycle arrest and reduced migration of AGS and HepG2 cells. |
[2] |
| Evidence Score (E-score) |
2 |
+ |
| 1 |
Luciferase Reporter Assay; Western Blot |
[1] |
| 2 |
Western Blot |
[2] |
| Representative Target(s) Regulated by This miRNA |
cAMP-dependent protein kinase A type I (PRKAR1A)
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Target Info
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Dual-specificity tyrosine-phosphorylation regulated kinase 1A (DYRK1A)
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Target Info
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| References |
Top |
| REF 1 |
p53 downregulates Down syndrome-associated DYRK1A through miR-1246. EMBO Rep. 2011 Jun 3;12(8):811-7.
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| REF 2 |
Inhibitors of enhancer of zeste homolog 2 (EZH2) activate tumor-suppressor microRNAs in human cancer cells. Oncogenesis. 2014 May 26;3:e104.
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