miRNA General Information
miRNA Mature ID hsa-miR-1246
miRNA Stemloop AC MI0006381
miRNA Stemloop ID hsa-mir-1246
Sequence aauggauuuuuggagcagg
TTD Target(s) Regulated by This miRNA Glycogen synthase kinase-3 beta (GSK-3B) Clinical trial Target Target Info [1]
Dual-specificity tyrosine-phosphorylation regulated kinase 1A (DYRK1A) Patented-recorded Target Target Info [2]
cAMP-dependent protein kinase A type I (PRKAR1A) Literature-reported Target Target Info [3]
Protein(s) Regulated by This miRNA Axin-2 Regulated Protein [1]
Nuclear factor 1 B-type Regulated Protein [5]
References
REF 1 Octamer 4/microRNA-1246 signaling axis drives Wnt/-catenin activation in liver cancer stem cells. Hepatology. 2016 Dec;64(6):2062-2076.
REF 2 Inhibitors of enhancer of zeste homolog 2 (EZH2) activate tumor-suppressor microRNAs in human cancer cells. Oncogenesis. 2014 May 26;3:e104.
REF 3 miRNA-1246 induces pro-inflammatory responses in mesenchymal stem/stromal cells by regulating PKA and PP2A. Oncotarget. 2017 Jul 4;8(27):43897-43914.
REF 4 Octamer 4/microRNA-1246 signaling axis drives Wnt/-catenin activation in liver cancer stem cells. Hepatology. 2016 Dec;64(6):2062-2076.
REF 5 p53-induced microRNA-1246 inhibits the cell growth of human hepatocellular carcinoma cells by targeting NFIB.Oncol Rep. 2015 Mar;33(3):1335-41.

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