Target Regulator(s) Information (MicroRNA)
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T76508 | Target Info | |||
| Target Name | MAPK/ERK kinase kinase 2 (MAP3K2) | ||||
| Synonyms | Mitogen-activated protein kinase kinase kinase 2; MEKK2; MEKK 2; MEK kinase 2; MAPKKK2 | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | MAP3K2 | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| The microRNAs (miRNAs) Regulating This Target | Top | ||||
|---|---|---|---|---|---|
| miRNA Mature ID | hsa-miR-520a-3p | miRNA Info | |||
| miRNA Mature AC | |||||
| Sequence | aaagugcuucccuuuggacugu | ||||
| miRNA Species | Homo sapiens | ||||
| Evidence Score (E-score) | 2 | + | |||
| 1 | Luciferase Reporter Assay | [1] | |||
| 2 | Luciferase Reporter Assay; Western Blot | [2] | |||
| Representative Target(s) Regulated by This miRNA | Extracellular matrix receptor III (CD44) | Target Info | |||
| G1/S-specific cyclin-D1 (CCND1) | Target Info | ||||
| miRNA Mature ID | hsa-miR-186-5p | miRNA Info | |||
| miRNA Mature AC | |||||
| Sequence | caaagaauucuccuuuugggcu | ||||
| miRNA Species | Homo sapiens | ||||
| Regulation Mechanism | miR-186 directly targets MAP3K2 3'UTR. | [3] | |||
| Evidence Score (E-score) | 1 | + | |||
| 1 | Luciferase Reporter Assay; Western Blot | [3] | |||
| Representative Target(s) Regulated by This miRNA | Casein kinase II alpha (CSNK2A1) | Target Info | |||
| Fibroblast growth factor-2 (FGF2) | Target Info | ||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Long noncoding RNA HOXA-AS2 promotes non-small cell lung cancer progression by regulating miR-520a-3p. Biosci Rep. 2019 May 31;39(5). pii: BSR20190283. | ||||
| REF 2 | The microRNA-520a-3p inhibits proliferation, apoptosis and metastasis by targeting MAP3K2 in non-small cell lung cancer. Am J Cancer Res. 2015 Jan 15;5(2):802-11. | ||||
| REF 3 | MicroRNA-186 suppresses cell proliferation and metastasis through targeting MAP3K2 in non-small cell lung cancer. Int J Oncol. 2016 Oct;49(4):1437-44. | ||||
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