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| Target General Information |
Top |
| Target ID |
T29736 |
Target Info
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| Target Name |
Laminin beta-3 chain (LAMB3) |
| Synonyms |
Nicein subunit beta; Laminin5beta3; Laminin-5 subunit beta; Laminin subunit beta-3; Laminin B1k chain; Laminin 5 beta 3; LAMNB1; Kalinin subunit beta; Kalinin B1 chain; Epiligrin subunit bata |
| Target Type |
Clinical trial Target |
| Gene Name |
LAMB3 |
| UniProt ID |
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| The microRNAs (miRNAs) Regulating This Target |
Top |
| miRNA Mature ID |
hsa-miR-218-5p |
miRNA Info
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| miRNA Mature AC |
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| Sequence |
uugugcuugaucuaaccaugu
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| miRNA Species |
Homo sapiens |
| Regulation Mechanism |
The overexpression of miR-218-5p by mature miRNA precursor transfection resulted in the changed mRNA level of target LAMB3. |
[2] |
| Evidence Score (E-score) |
2 |
+ |
| 1 |
Literature Reported |
[1] |
| 2 |
qRT-PCR |
[2] |
| Representative Target(s) Regulated by This miRNA |
Laminin beta-3 chain (LAMB3)
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Target Info
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|
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Transcription factor Sp1 (SP1)
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Target Info
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| References |
Top |
| REF 1 |
Polymorphisms involved in the miR-218-LAMB3 pathway and susceptibility of cervical cancer, a case-control study in Chinese women. Gynecol Oncol. 2010 May;117(2):287-90.
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| REF 2 |
Human papillomavirus type 16 reduces the expression of microRNA-218 in cervical carcinoma cells. Oncogene. 2008 Apr 17;27(18):2575-82.
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