miRNA Details
miRNA General Information | |||||
---|---|---|---|---|---|
miRNA Mature ID | hsa-miR-218-5p | ||||
miRNA Stemloop AC | MI0000294 | MI0000295 | ||||
miRNA Stemloop ID | hsa-mir-218-1 | hsa-mir-218-2 | ||||
Sequence | uugugcuugaucuaaccaugu | ||||
TTD Target(s) Regulated by This miRNA | Laminin beta-3 chain (LAMB3) | Clinical trial Target | Target Info | [1] | |
Transcription factor Sp1 (SP1) | Clinical trial Target | Target Info | [2] | ||
Protein(s) Regulated by This miRNA | 28S ribosomal protein S27, mitochondrial | Regulated Protein | [1] | ||
Alpha-actinin-1 | Regulated Protein | [4] | |||
B-cell CLL/lymphoma 9 protein | Regulated Protein | [5] | |||
Baculoviral IAP repeat-containing protein 6 | Regulated Protein | [4] | |||
Endophilin-A2 | Regulated Protein | [6] | |||
Endoplasmic reticulum membrane sensor NFE2L1 | Regulated Protein | [7] | |||
Ephrin-A1 | Regulated Protein | [1] | |||
Homeobox protein Hox-B3 | Regulated Protein | [8] | |||
Leucine-rich repeat-containing G-protein coupled receptor 4 | Regulated Protein | [9] | |||
LIM and SH3 domain protein 1 | Regulated Protein | [7] | |||
Lymphoid enhancer-binding factor 1 | Regulated Protein | [10] | |||
Microphthalmia-associated transcription factor | Regulated Protein | [11] | |||
Nuclear pore complex protein Nup93 | Regulated Protein | [1] | |||
OTU domain-containing protein 7B | Regulated Protein | [12] | |||
POU domain, class 2, transcription factor 2 | Regulated Protein | [13] | |||
Protein Tob1 | Regulated Protein | [14] | |||
Roundabout homolog 1 | Regulated Protein | [15] | |||
Secreted frizzled-related protein 2 | Regulated Protein | [16] | |||
Signal transducing adapter molecule 2 | Regulated Protein | [4] | |||
Slit homolog 2 protein | Regulated Protein | [17] | |||
Slit homolog 3 protein | Regulated Protein | [17] | |||
Transcription factor MafG | Regulated Protein | [7] | |||
Vacuolar protein sorting-associated protein 51 homolog | Regulated Protein | [18] | |||
Vesicular, overexpressed in cancer, prosurvival protein 1 | Regulated Protein | [7] | |||
Wiskott-Aldrich syndrome protein family member 3 | Regulated Protein | [19] | |||
References | |||||
REF 1 | Human papillomavirus type 16 reduces the expression of microRNA-218 in cervical carcinoma cells. Oncogene. 2008 Apr 17;27(18):2575-82. | ||||
REF 2 | The oncogenic microRNA-27a targets genes that regulate specificity protein transcription factors and the G2-M checkpoint in MDA-MB-231 breast cancer cells. Cancer Res. 2007 Nov 15;67(22):11001-11. | ||||
REF 3 | Human papillomavirus type 16 reduces the expression of microRNA-218 in cervical carcinoma cells. Oncogene. 2008 Apr 17;27(18):2575-82. | ||||
REF 4 | Reduced microRNA-218 expression is associated with high nuclear factor kappa B activation in gastric cancer.Cancer. 2010 Jan 1;116(1):41-9. | ||||
REF 5 | Differentially expressed microRNA-218odulates the viability of renal cell carcinoma by regulating BCL9.Mol Med Rep. 2016 Aug;14(2):1829-34. | ||||
REF 6 | miR-218 is downregulated and directly targets SH3GL1 in childhood medulloblastoma.Mol Med Rep. 2013 Oct;8(4):1111-7. | ||||
REF 7 | MicroRNAs as modulators of smoking-induced gene expression changes in human airway epithelium.Proc Natl Acad Sci U S A. 2009 Feb 17;106(7):2319-24. | ||||
REF 8 | miR-7 and miR-218 epigenetically control tumor suppressor genes RASSF1A and Claudin-6 by targeting HoxB3 in breast cancer.Biochem Biophys Res Commun. 2012 Jul 20;424(1):28-33. | ||||
REF 9 | MiR-218 impedes IL-6-induced prostate cancer cell proliferation and invasion via suppression of LGR4 expression.Oncol Rep. 2016 May;35(5):2859-65. | ||||
REF 10 | MiR-218 reverses high invasiveness of glioblastoma cells by targeting the oncogenic transcription factor LEF1.Oncol Rep. 2012 Sep;28(3):1013-21. | ||||
REF 11 | Mir-218 contributes to the transformation of 5-Aza/GF induced umbilical cord mesenchymal stem cells into hematopoietic cells through the MITF pathway.Mol Biol Rep. 2014 Jul;41(7):4803-16. | ||||
REF 12 | miR-218 regulates focal adhesion kinase-dependent TGF signaling in fibroblasts.Mol Biol Cell. 2014 Apr;25(7):1151-8. | ||||
REF 13 | POU2F2-oriented network promotes human gastric cancer metastasis.Gut. 2016 Sep;65(9):1427-38. | ||||
REF 14 | miR-218 directs a Wnt signaling circuit to promote differentiation of osteoblasts and osteomimicry of metastatic cancer cells.J Biol Chem. 2012 Dec 7;287(50):42084-92. | ||||
REF 15 | MiR-218 suppresses nasopharyngeal cancer progression through downregulation of survivin and the SLIT2-ROBO1 pathway.Cancer Res. 2011 Mar 15;71(6):2381-91. | ||||
REF 16 | MicroRNAs modulate the Wnt signaling pathway through targeting its inhibitors.Biochem Biophys Res Commun. 2011 May 6;408(2):259-64. | ||||
REF 17 | Specific expression and methylation of SLIT1, SLIT2, SLIT3, and miR-218 in gastric cancer subtypes.Int J Oncol. 2016 Jun;48(6):2497-507. | ||||
REF 18 | miR-218 suppresses gastric cancer cell proliferation and invasion via regulation of angiopoietin-2.Exp Ther Med. 2016 Dec;12(6):3837-3842. | ||||
REF 19 | miR-218 Inhibits Proliferation, Migration, and EMT of Gastric Cancer Cells by Targeting WASF3.Oncol Res. 2017 Mar 13;25(3):355-364. |
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