miRNA General Information
miRNA Mature ID hsa-miR-218-5p
miRNA Stemloop AC MI0000294 | MI0000295
miRNA Stemloop ID hsa-mir-218-1 | hsa-mir-218-2
Sequence uugugcuugaucuaaccaugu
TTD Target(s) Regulated by This miRNA Laminin beta-3 chain (LAMB3) Clinical trial Target Target Info [1]
Transcription factor Sp1 (SP1) Clinical trial Target Target Info [2]
Protein(s) Regulated by This miRNA 28S ribosomal protein S27, mitochondrial Regulated Protein [1]
Alpha-actinin-1 Regulated Protein [4]
B-cell CLL/lymphoma 9 protein Regulated Protein [5]
Baculoviral IAP repeat-containing protein 6 Regulated Protein [4]
Endophilin-A2 Regulated Protein [6]
Endoplasmic reticulum membrane sensor NFE2L1 Regulated Protein [7]
Ephrin-A1 Regulated Protein [1]
Homeobox protein Hox-B3 Regulated Protein [8]
Leucine-rich repeat-containing G-protein coupled receptor 4 Regulated Protein [9]
LIM and SH3 domain protein 1 Regulated Protein [7]
Lymphoid enhancer-binding factor 1 Regulated Protein [10]
Microphthalmia-associated transcription factor Regulated Protein [11]
Nuclear pore complex protein Nup93 Regulated Protein [1]
OTU domain-containing protein 7B Regulated Protein [12]
POU domain, class 2, transcription factor 2 Regulated Protein [13]
Protein Tob1 Regulated Protein [14]
Roundabout homolog 1 Regulated Protein [15]
Secreted frizzled-related protein 2 Regulated Protein [16]
Signal transducing adapter molecule 2 Regulated Protein [4]
Slit homolog 2 protein Regulated Protein [17]
Slit homolog 3 protein Regulated Protein [17]
Transcription factor MafG Regulated Protein [7]
Vacuolar protein sorting-associated protein 51 homolog Regulated Protein [18]
Vesicular, overexpressed in cancer, prosurvival protein 1 Regulated Protein [7]
Wiskott-Aldrich syndrome protein family member 3 Regulated Protein [19]
References
REF 1 Human papillomavirus type 16 reduces the expression of microRNA-218 in cervical carcinoma cells. Oncogene. 2008 Apr 17;27(18):2575-82.
REF 2 The oncogenic microRNA-27a targets genes that regulate specificity protein transcription factors and the G2-M checkpoint in MDA-MB-231 breast cancer cells. Cancer Res. 2007 Nov 15;67(22):11001-11.
REF 3 Human papillomavirus type 16 reduces the expression of microRNA-218 in cervical carcinoma cells. Oncogene. 2008 Apr 17;27(18):2575-82.
REF 4 Reduced microRNA-218 expression is associated with high nuclear factor kappa B activation in gastric cancer.Cancer. 2010 Jan 1;116(1):41-9.
REF 5 Differentially expressed microRNA-218odulates the viability of renal cell carcinoma by regulating BCL9.Mol Med Rep. 2016 Aug;14(2):1829-34.
REF 6 miR-218 is downregulated and directly targets SH3GL1 in childhood medulloblastoma.Mol Med Rep. 2013 Oct;8(4):1111-7.
REF 7 MicroRNAs as modulators of smoking-induced gene expression changes in human airway epithelium.Proc Natl Acad Sci U S A. 2009 Feb 17;106(7):2319-24.
REF 8 miR-7 and miR-218 epigenetically control tumor suppressor genes RASSF1A and Claudin-6 by targeting HoxB3 in breast cancer.Biochem Biophys Res Commun. 2012 Jul 20;424(1):28-33.
REF 9 MiR-218 impedes IL-6-induced prostate cancer cell proliferation and invasion via suppression of LGR4 expression.Oncol Rep. 2016 May;35(5):2859-65.
REF 10 MiR-218 reverses high invasiveness of glioblastoma cells by targeting the oncogenic transcription factor LEF1.Oncol Rep. 2012 Sep;28(3):1013-21.
REF 11 Mir-218 contributes to the transformation of 5-Aza/GF induced umbilical cord mesenchymal stem cells into hematopoietic cells through the MITF pathway.Mol Biol Rep. 2014 Jul;41(7):4803-16.
REF 12 miR-218 regulates focal adhesion kinase-dependent TGF signaling in fibroblasts.Mol Biol Cell. 2014 Apr;25(7):1151-8.
REF 13 POU2F2-oriented network promotes human gastric cancer metastasis.Gut. 2016 Sep;65(9):1427-38.
REF 14 miR-218 directs a Wnt signaling circuit to promote differentiation of osteoblasts and osteomimicry of metastatic cancer cells.J Biol Chem. 2012 Dec 7;287(50):42084-92.
REF 15 MiR-218 suppresses nasopharyngeal cancer progression through downregulation of survivin and the SLIT2-ROBO1 pathway.Cancer Res. 2011 Mar 15;71(6):2381-91.
REF 16 MicroRNAs modulate the Wnt signaling pathway through targeting its inhibitors.Biochem Biophys Res Commun. 2011 May 6;408(2):259-64.
REF 17 Specific expression and methylation of SLIT1, SLIT2, SLIT3, and miR-218 in gastric cancer subtypes.Int J Oncol. 2016 Jun;48(6):2497-507.
REF 18 miR-218 suppresses gastric cancer cell proliferation and invasion via regulation of angiopoietin-2.Exp Ther Med. 2016 Dec;12(6):3837-3842.
REF 19 miR-218 Inhibits Proliferation, Migration, and EMT of Gastric Cancer Cells by Targeting WASF3.Oncol Res. 2017 Mar 13;25(3):355-364.

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