Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T94197 | Target Info | |||
| Target Name | Protein kinase N2 (PKN2) | ||||
| Synonyms | Serine/threonine-protein kinase N2; Protein-kinase C-related kinase 2; Protein kinase C-like 2; PRKCL2; PRK2; PKN gamma | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | PKN2 | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | Phosphonothreonine | Ligand Info | |||
| Canonical SMILES | CC(C(C(=O)O)N)OP(=O)(O)O | ||||
| InChI | 1S/C4H10NO6P/c1-2(3(5)4(6)7)11-12(8,9)10/h2-3H,5H2,1H3,(H,6,7)(H2,8,9,10)/t2-,3+/m1/s1 | ||||
| InChIKey | USRGIUJOYOXOQJ-GBXIJSLDSA-N | ||||
| PubChem Compound ID | 3246323 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 6CCY Crystal structure of Akt1 in complex with a selective inhibitor | ||||||
| Method | X-ray diffraction | Resolution | 2.18 Å | Mutation | Yes | [1] |
| PDB Sequence |
GSLRVTMNEF
150 EYLKLLGKGT160 FGKVILVKEK170 ATGRYYAMKI180 LKKEVIVAKD190 EVAHTLTESR 200 VLQNSRHPFL210 TALKYSFQTH220 DRLCFVMEYA230 NGGELFFHLS240 RERVFSEDRA 250 RFYGAEIVSA260 LDYLHSEKNV270 VYRDLKLENL280 MLDKDGHIKI290 TDFGLCKEGI 300 KDGATMKFCG311 TPEYLAPEVL321 EDNDYGRAVD331 WWGLGVVMYE341 MMCGRLPFYN 351 QDHEKLFELI361 LMEEIRFPRT371 LGPEAKSLLS381 GLLKKDPKQR391 LGGGPSDAKE 401 IMQHRFFAGI411 VWQHVYEKKL421 SPPFKPQVTS431 EVDTRYFDEE441 FTAQMITITE 468 QEMFRDFDYI478 ADWEG
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| PDB ID: 4CRS Human Protein Kinase N2 (PKN2, PRKCL2) in complex with ATPgammaS | ||||||
| Method | X-ray diffraction | Resolution | 2.75 Å | Mutation | No | [2] |
| PDB Sequence |
SMSQQRFQFN
653 LQDFRCCAVL663 LRGHFGKVLL673 AEYKNTNEMF683 AIKALKKGDI693 VARDEVDSLM 703 CEKRIFETVN713 SVRHPFLVNL723 FACFQTKEHV733 CFVMEYAAGG743 DLMMHIHTDV 753 FEPRAVFYAA764 CVVLGLQYLH774 EHKIVYRDLK784 LDNLLLDTEG794 FVKIADFGLC 804 KEGMGYGDRT814 SFCGTPEFLA825 PEVLTETSYT835 RAVDWWGLGV845 LIYEMLVGES 855 PFPGDDEEEV865 FDSIVNDEVR875 YPRFLSTEAI885 SIMRRLLRRN895 PERRLGASEK 905 DAEDVKKHPF915 FRLIDWSALM925 DKKVKPPFIP935 TIRGREDVSN945 FDDEFTSEAP 955 ILPPREPREM973 FRDFDYIADW983 C
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Discovery of chiral dihydropyridopyrimidinones as potent, selective and orally bioavailable inhibitors of AKT. Bioorg Med Chem Lett. 2018 Jun 1;28(10):1887-1891. | ||||
| REF 2 | Structure of Pkn2 | ||||
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