Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T87166 | Target Info | |||
| Target Name | Glucokinase (GCK) | ||||
| Synonyms | Hexokinase type IV; Hexokinase D; HK4; HK IV | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | GCK | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | AMP-PNP | Ligand Info | |||
| Canonical SMILES | C1=NC(=C2C(=N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)OP(=O)(NP(=O)(O)O)O)O)O)N | ||||
| InChI | 1S/C10H17N6O12P3/c11-8-5-9(13-2-12-8)16(3-14-5)10-7(18)6(17)4(27-10)1-26-31(24,25)28-30(22,23)15-29(19,20)21/h2-4,6-7,10,17-18H,1H2,(H,24,25)(H2,11,12,13)(H4,15,19,20,21,22,23)/t4-,6-,7-,10-/m1/s1 | ||||
| InChIKey | PVKSNHVPLWYQGJ-KQYNXXCUSA-N | ||||
| PubChem Compound ID | 33113 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 3FGU Catalytic complex of Human Glucokinase | ||||||
| Method | X-ray diffraction | Resolution | 2.15 Å | Mutation | No | [1] |
| PDB Sequence |
NLYFQGMKKE
14 KVEQILAEFQ24 LQEEDLKKVM34 RRMQKEMDRG44 LRLETHEEAS54 VKMLPTYVRS 64 TPSEVGDFLS76 LDLGGTNFRV86 MLVKVGEGQW99 SVKTKHQMYS109 IPEDAMTGTA 119 EMLFDYISEC129 ISDFLDKHQM139 KKLPLGFTFS151 FPVRHEDIDK161 GILLNWTKGF 171 KASGAEGNNV181 VGLLRDAIKR191 RGDFEMDVVA201 MVNDTVATMI211 SCYYEDHQCE 221 VGMIVGTGCN231 ACYMEEMQNV241 ELVEGDEGRM251 CVNTEWGAFG261 DSGELDEFLL 271 EYDRLVDESS281 ANPGQQLYEK291 LIGGKYMGEL301 VRLVLLRLVD311 ENLLFHGEAS 321 EQLRTRGAFE331 TRFVSQVESD341 TGDRKQIYNI351 LSTLGLRPST361 TDCDIVRRAC 371 ESVSTRAAHM381 CSAGLAGVIN391 RMRESRSEDV401 MRITVGVDGS411 VYKLHPSFKE 421 RFHASVRRLT431 PSCEITFIES441 EEGSGRGAAL451 VSAVACK
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GLY80
3.981
GLY81
4.078
ARG85
4.482
SER151
4.465
LYS169
3.024
ASP205
3.475
ILE225
2.421
GLY227
3.649
THR228
2.767
GLY229
2.270
CYS230
4.787
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| PDB ID: 3ID8 Ternary complex of human pancreatic glucokinase crystallized with activator, glucose and AMP-PNP | ||||||
| Method | X-ray diffraction | Resolution | 2.40 Å | Mutation | No | [1] |
| PDB Sequence |
NLYFQGMKKE
14 KVEQILAEFQ24 LQEEDLKKVM34 RRMQKEMDRG44 LRLETHEEAS54 VKMLPTYVRS 64 TPEGSEVGDF74 LSLDLGGTNF84 RVMLVKVGEG94 QWSVKTKHQM107 YSIPEDAMTG 117 TAEMLFDYIS127 ECISDFLDKH137 QMKHKKLPLG147 FTFSFPVRHE157 DIDKGILLNW 167 TKGFKASGAE177 GNNVVGLLRD187 AIKRRGDFEM197 DVVAMVNDTV207 ATMISCYYED 217 HQCEVGMIVG227 TGCNACYMEE237 MQNVELVEGD247 EGRMCVNTEW257 GAFGDSGELD 267 EFLLEYDRLV277 DESSANPGQQ287 LYEKLIGGKY297 MGELVRLVLL307 RLVDENLLFH 317 GEASEQLRTR327 GAFETRFVSQ337 VESDTGDRKQ347 IYNILSTLGL357 RPSTTDCDIV 367 RRACESVSTR377 AAHMCSAGLA387 GVINRMRESR397 SEDVMRITVG407 VDGSVYKLHP 417 SFKERFHASV427 RRLTPSCEIT437 FIESEEGSGR447 GAALVSAVAC457 |
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | The active conformation of human glucokinase is not altered by allosteric activators. Acta Crystallogr D Biol Crystallogr. 2011 Nov;67(Pt 11):929-35. | ||||
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