Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T67658 | Target Info | |||
| Target Name | Glucose transporter type 4 (SLC2A4) | ||||
| Synonyms | Solute carrier family 2, facilitated glucose transporter member 4; Glut4 protein; Glucose transporter type 4, insulin-responsive; GLUT4; GLUT-4 | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | SLC2A4 | ||||
| Biochemical Class | Major facilitator | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | Preverex | Ligand Info | |||
| Canonical SMILES | CC1CCCC(C=CC(=O)OC23C(C=CC1)C(C(=C)C(C2C(NC3=O)CC4=CC=CC=C4)C)O)O | ||||
| InChI | 1S/C29H37NO5/c1-18-9-7-13-22(31)15-16-25(32)35-29-23(14-8-10-18)27(33)20(3)19(2)26(29)24(30-28(29)34)17-21-11-5-4-6-12-21/h4-6,8,11-12,14-16,18-19,22-24,26-27,31,33H,3,7,9-10,13,17H2,1-2H3,(H,30,34)/b14-8+,16-15+/t18-,19-,22-,23+,24+,26+,27-,29-/m1/s1 | ||||
| InChIKey | GBOGMAARMMDZGR-TYHYBEHESA-N | ||||
| PubChem Compound ID | 5311281 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 7WSM Cryo-EM structure of human glucose transporter GLUT4 bound to cytochalasin B in lipid nanodiscs | ||||||
| Method | Electron microscopy | Resolution | 3.25 Å | Mutation | No | [1] |
| PDB Sequence |
TGTLVLAVFS
30 AVLGSLQFGY40 NIGVINAPQK50 VIEQSYNETW60 LGRQGPEGPS70 SIPPGTLTTL 80 WALSVAIFSV90 GGMISSFLIG100 IISQWLGRKR110 AMLVNNVLAV120 LGGSLMGLAN 130 AAASYEMLIL140 GRFLIGAYSG150 LTSGLVPMYV160 GEIAPTHLRG170 ALGTLNQLAI 180 VIGILIAQVL190 GLESLLGTAS200 LWPLLLGLTV210 LPALLQLVLL220 PFCPESPRYL 230 YIIQNLEGPA240 RKSLKRLTGW250 ADVSGVLAEL260 KDEKRKLERE270 RPLSLLQLLG 280 SRTHRQPLII290 AVVLQLSQQL300 SGINAVFYYS310 TSIFETAGVG320 QPAYATIGAG 330 VVNTVFTLVS340 VLLVERAGRR350 TLHLLGLAGM360 CGCAILMTVA370 LLLLERVPAM 380 SYVSIVAIFG390 FVAFFEIGPG400 PIPWFIVAEL410 FSQGPRPAAM420 AVAGFSNWTS 430 NFIIGMGFQY440 VAEAMGPYVF450 LLFAVLLLGF460 FIFTFLRVPE470 TRGRTFDQIS 480 AAFH
|
|||||
|
|
PHE38
3.916
ILE42
4.281
SER153
3.533
PRO157
4.017
ASN176
3.833
GLN177
3.569
ILE180
3.691
ILE184
4.100
GLN298
2.479
GLN299
3.127
ILE303
3.910
|
|||||
| PDB ID: 7WSN Cryo-EM structure of human glucose transporter GLUT4 bound to cytochalasin B in detergent micelles | ||||||
| Method | Electron microscopy | Resolution | 3.31 Å | Mutation | No | [1] |
| PDB Sequence |
TGTLVLAVFS
30 AVLGSLQFGY40 NIGVINAPQK50 VIEQSYNETW60 LGRQGPEGPS70 SIPPGTLTTL 80 WALSVAIFSV90 GGMISSFLIG100 IISQWLGRKR110 AMLVNNVLAV120 LGGSLMGLAN 130 AAASYEMLIL140 GRFLIGAYSG150 LTSGLVPMYV160 GEIAPTHLRG170 ALGTLNQLAI 180 VIGILIAQVL190 GLESLLGTAS200 LWPLLLGLTV210 LPALLQLVLL220 PFCPESPRYL 230 YIIQNLEGPA240 RKSLKRLTGW250 ADVSGVLAEL260 KDEKRKLERE270 RPLSLLQLLG 280 SRTHRQPLII290 AVVLQLSQQL300 SGINAVFYYS310 TSIFETAGVG320 QPAYATIGAG 330 VVNTVFTLVS340 VLLVERAGRR350 TLHLLGLAGM360 CGCAILMTVA370 LLLLERVPAM 380 SYVSIVAIFG390 FVAFFEIGPG400 PIPWFIVAEL410 FSQGPRPAAM420 AVAGFSNWTS 430 NFIIGMGFQY440 VAEAMGPYVF450 LLFAVLLLGF460 FIFTFLRVPE470 TRGRTFDQIS 480 AAF
|
|||||
|
|
PHE38
3.944
ILE42
4.164
SER96
4.883
SER153
3.360
PRO157
3.935
ASN176
3.590
GLN177
3.709
ILE180
3.586
ILE184
4.017
GLN298
2.783
GLN299
2.912
ILE303
3.844
|
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Cryo-EM structure of human glucose transporter GLUT4. Nat Commun. 2022 May 13;13(1):2671. | ||||
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