Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T62265 | Target Info | |||
| Target Name | Deoxyhypusine synthase (DHPS) | ||||
| Synonyms | DHS | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | DHPS | ||||
| Biochemical Class | Alkyl aryl transferase | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | Spermidine | Ligand Info | |||
| Canonical SMILES | C(CCNCCCN)CN | ||||
| InChI | 1S/C7H19N3/c8-4-1-2-6-10-7-3-5-9/h10H,1-9H2 | ||||
| InChIKey | ATHGHQPFGPMSJY-UHFFFAOYSA-N | ||||
| PubChem Compound ID | 1102 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 6XXJ Crystal Structure of Human Deoxyhypusine Synthase in complex with spermidine and NAD | ||||||
| Method | X-ray diffraction | Resolution | 1.41 Å | Mutation | No | [1] |
| PDB Sequence |
EAPAGALAAV
17 LKHSSTLPPE27 STQVRGYDFN37 RGVNYRALLE47 AFGTTGFQAT57 NFGRAVQQVN 67 AMIEKKLEPL77 SQDEDQHADL87 TQSRRPLTSC97 TIFLGYTSNL107 ISSGIRETIR 117 YLVQHNMVDV127 LVTTAGGVEE137 DLIKCLAPTY147 LGEFSLRGKE157 LRENGINRIG 167 NLLVPNENYK178 FEDWLMPILD188 QMVMEQNTEG198 VKWTPSKMIA208 RLGKEINNPE 218 SVYYWAQKNH228 IPVFSPALTD238 GSLGDMIFFH248 SYKNPGLVLD258 IVEDLRLINT 268 QAIFAKCTGM278 IILGGGVVKH288 HIANANLMRN298 GADYAVYINT308 AQEFDGSDSG 318 ARPDEAVSWG328 KIRVDAQPVK338 VYADASLVFP348 LLVAETFAQK358 MDAFM |
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| PDB ID: 6XXK Crystal Structure of Human Deoxyhypusine Synthase in complex with spermidine | ||||||
| Method | X-ray diffraction | Resolution | 1.65 Å | Mutation | No | [1] |
| PDB Sequence |
APAGALAAVL
18 KHSSTLPPES28 TQVRGYDFNR38 GVNYRALLEA48 FGTTGFQATN58 FGRAVQQVNA 68 MIEKKLEPLS78 QDEDQHADLT88 QSRRPLTSCT98 IFLGYTSNLI108 SSGIRETIRY 118 LVQHNMVDVL128 VTTAGGVEED138 LIKCLAPTYL148 GEFSLRGKEL158 RENGINRIGN 168 LLVPNENYKF179 EDWLMPILDQ189 MVMEQNTEGV199 KWTPSKMIAR209 LGKEINNPES 219 VYYWAQKNHI229 PVFSPALTDG239 SLGDMIFFHS249 YKNPGLVLDI259 VEDLRLINTQ 269 AIFAKCTGMI279 ILGGGVVKHH289 IANANLMRNG299 ADYAVYINTA309 QEFDGSDSGA 319 RPDEAVSWGK329 IRVDAQPVKV339 YADASLVFPL349 LVAETFAQKM359 DAFM |
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| PDB ID: 7A6T Crystal Structure of Asn173Ser variant of Human Deoxyhypusine Synthase in complex with NAD and spermidine | ||||||
| Method | X-ray diffraction | Resolution | 1.66 Å | Mutation | Yes | [2] |
| PDB Sequence |
STQVRGYDFN
37 RGVNYRALLE47 AFGTTGFQAT57 NFGRAVQQVN67 AMIEKKLEPL77 SQDEDQHADL 87 TQSRRPLTSC97 TIFLGYTSNL107 ISSGIRETIR117 YLVQHNMVDV127 LVTTAGGVEE 137 DLIKCLAPTY147 LGEFSLRGKE157 LRENGINRIG167 NLLVPSENYK178 FEDWLMPILD 188 QMVMEQNTEG198 VKWTPSKMIA208 RLGKEINNPE218 SVYYWAQKNH228 IPVFSPALTD 238 GSLGDMIFFH248 SYKNPGLVLD258 IVEDLRLINT268 QAIFAKCTGM278 IILGGGVVKH 288 HIANANLMRN298 GADYAVYINT308 AQEFDGSDSG318 ARPDEAVSWG328 KIRVDAQPVK 338 VYADASLVFP348 LLVAETFAQK358 MDAFM
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Half Way to Hypusine-Structural Basis for Substrate Recognition by Human Deoxyhypusine Synthase. Biomolecules. 2020 Mar 30;10(4):522. | ||||
| REF 2 | Cryo-EM structure of human eIF5A-DHS complex reveals the molecular basis of hypusination-associated neurodegenerative disorders. Nat Commun. 2023 Mar 27;14(1):1698. | ||||
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