Target Binding Site Detail

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Target General Information
Ligand General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T57613 Target Info
Target Name TWIK-related acid-sensitive potassium channel 3 (TASK3)
Synonyms Two pore potassium channel KT3.2; TWIK-related acid-sensitive K+ channel 3; KCNK9; Acid-sensitive potassium channel protein TASK-3
Target Type Literature-reported Target
Gene Name KCNK9
UniProt ID
KCNK9_HUMAN
Ligand General Information  Top
Ligand Name L-serine-O-phosphate Ligand Info
Canonical SMILES C(C(C(=O)O)N)OP(=O)(O)O
InChI 1S/C3H8NO6P/c4-2(3(5)6)1-10-11(7,8)9/h2H,1,4H2,(H,5,6)(H2,7,8,9)/t2-/m0/s1
InChIKey BZQFBWGGLXLEPQ-REOHCLBHSA-N
PubChem Compound ID 68841
Drug Binding Sites of Target  Top
PDB ID: 6GHP      14-3-3sigma in complex with a TASK3 peptide stabilized by semi-synthetic natural product FC-NAc
Method X-ray diffraction Resolution 1.95 Å Mutation No [1]
PDB Sequence
RRKV
Residue
Distance (Å)
ARG370
3.937
ARG371
1.928
Residue
Distance (Å)
LYS372
1.330
VAL374
1.329
PDB ID: 3P1S      Crystal structure of human 14-3-3 sigma C38N/N166H in complex with TASK-3 peptide and stabilizer fusicoccin A
Method X-ray diffraction Resolution 1.65 Å Mutation Yes [2]
PDB Sequence
KRRKV
Residue
Distance (Å)
ARG370
4.675
ARG371
2.739
Residue
Distance (Å)
LYS372
1.330
VAL374
1.332
PDB ID: 3P1Q      Crystal structure of human 14-3-3 sigma C38N/N166H in complex with TASK-3 Peptide and stabilizer fusicoccin A
Method X-ray diffraction Resolution 1.70 Å Mutation Yes [2]
PDB Sequence
KRRKV
Residue
Distance (Å)
ARG370
4.583
ARG371
2.626
Residue
Distance (Å)
LYS372
1.327
VAL374
1.326
PDB ID: 3UX0      Crystal structure of human 14-3-3 sigma in complex with TASK-3 peptide and stabilizer Fusicoccin H
Method X-ray diffraction Resolution 1.75 Å Mutation No [2]
PDB Sequence
KRRKV
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .SEP or .SEP2 or .SEP3 or :3SEP;style chemicals stick;color identity;select .P:370 or .P:371 or .P:372 or .P:374; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
Residue
Distance (Å)
ARG370
4.523
ARG371
2.771
Residue
Distance (Å)
LYS372
1.344
VAL374
1.336
PDB ID: 3SMO      Crystal structure of human 14-3-3 sigma C38V/N166H in complex with TASK-3 peptide and stabilizer Fusicoccin J aglycone
Method X-ray diffraction Resolution 1.80 Å Mutation Yes [2]
PDB Sequence
KRRKV
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .SEP or .SEP2 or .SEP3 or :3SEP;style chemicals stick;color identity;select .P:370 or .P:371 or .P:372 or .P:374; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
Residue
Distance (Å)
ARG370
4.596
ARG371
2.799
Residue
Distance (Å)
LYS372
1.344
VAL374
1.335
PDB ID: 3SP5      Crystal structure of human 14-3-3 sigma C38V/N166H in complex with TASK-3 peptide and stabilizer Cotylenol
Method X-ray diffraction Resolution 1.80 Å Mutation Yes [2]
PDB Sequence
KRRKV
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .SEP or .SEP2 or .SEP3 or :3SEP;style chemicals stick;color identity;select .P:370 or .P:371 or .P:372 or .P:374; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
Residue
Distance (Å)
ARG370
4.576
ARG371
2.795
Residue
Distance (Å)
LYS372
1.345
VAL374
1.332
PDB ID: 3P1O      Crystal structure of human 14-3-3 sigma in complex with TASK-3 peptide and stabilisator Fusicoccin A
Method X-ray diffraction Resolution 1.90 Å Mutation No [2]
PDB Sequence
KRRKV
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .SEP or .SEP2 or .SEP3 or :3SEP;style chemicals stick;color identity;select .P:370 or .P:371 or .P:372 or .P:374; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
Residue
Distance (Å)
ARG370
4.454
ARG371
2.756
Residue
Distance (Å)
LYS372
1.331
VAL374
1.314
PDB ID: 4FR3      Crystal structure of human 14-3-3 sigma in complex with TASK-3 peptide and stabilizer 16-O-Me-FC-H
Method X-ray diffraction Resolution 1.90 Å Mutation No [2]
PDB Sequence
KRRKV
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .SEP or .SEP2 or .SEP3 or :3SEP;style chemicals stick;color identity;select .P:-2 or .P:-1 or .P:0 or .P:2; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
Residue
Distance (Å)
ARG-2
4.702
ARG-1
2.643
Residue
Distance (Å)
LYS0
1.312
VAL2
1.303
PDB ID: 3SPR      Crystal structure of human 14-3-3 sigma C38V/N166H in complex with TASK-3 peptide and stabilizer FC-THF
Method X-ray diffraction Resolution 1.99 Å Mutation Yes [2]
PDB Sequence
KRRKV
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .SEP or .SEP2 or .SEP3 or :3SEP;style chemicals stick;color identity;select .P:370 or .P:371 or .P:372 or .P:374; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
Residue
Distance (Å)
ARG370
4.288
ARG371
2.604
Residue
Distance (Å)
LYS372
1.319
VAL374
1.314
PDB ID: 3SMM      Crystal structure of human 14-3-3 sigma C38N/N166H in complex with task-3 peptide and stabilizer Fusicoccin J aglycone
Method X-ray diffraction Resolution 2.00 Å Mutation Yes [2]
PDB Sequence
KRRKV
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .SEP or .SEP2 or .SEP3 or :3SEP;style chemicals stick;color identity;select .P:370 or .P:371 or .P:372 or .P:374; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
Residue
Distance (Å)
ARG370
4.684
ARG371
2.610
Residue
Distance (Å)
LYS372
1.322
VAL374
1.330
PDB ID: 3SMN      Crystal structure of human 14-3-3 sigma C38N/N166H in complex with task-3 peptide and stabilizer Fusicoccin A-THF
Method X-ray diffraction Resolution 2.00 Å Mutation Yes [2]
PDB Sequence
KRRKV
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .SEP or .SEP2 or .SEP3 or :3SEP;style chemicals stick;color identity;select .P:370 or .P:371 or .P:372 or .P:374; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
Residue
Distance (Å)
ARG370
4.703
ARG371
2.653
Residue
Distance (Å)
LYS372
1.334
VAL374
1.326
PDB ID: 3SMK      Crystal structure of human 14-3-3 sigma C38V/N166H in complex with TASK-3 peptide and stabilizer Cotylenin A
Method X-ray diffraction Resolution 2.10 Å Mutation Yes [2]
PDB Sequence
KRRKV
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .SEP or .SEP2 or .SEP3 or :3SEP;style chemicals stick;color identity;select .P:370 or .P:371 or .P:372 or .P:374; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
Residue
Distance (Å)
ARG370
4.912
ARG371
2.877
Residue
Distance (Å)
LYS372
1.332
VAL374
1.323
PDB ID: 3SML      Crystal structure of human 14-3-3 sigma C38N/N166H in complex with TASK-3 peptide and stabilizer Fusicoccin A aglycone
Method X-ray diffraction Resolution 1.90 Å Mutation Yes [2]
PDB Sequence
RRKV
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .SEP or .SEP2 or .SEP3 or :3SEP;style chemicals stick;color identity;select .P:370 or .P:371 or .P:372 or .P:374; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
Residue
Distance (Å)
ARG370
4.680
ARG371
2.707
Residue
Distance (Å)
LYS372
1.331
VAL374
1.325
References  Top
REF 1 Rationally Designed Semisynthetic Natural Product Analogues for Stabilization of 14-3-3 Protein-Protein Interactions. Angew Chem Int Ed Engl. 2018 Oct 8;57(41):13470-13474.
REF 2 A semisynthetic fusicoccane stabilizes a protein-protein interaction and enhances the expression of K+ channels at the cell surface. Chem Biol. 2013 Apr 18;20(4):583-93.

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