Target Binding Site Detail

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Target General Information
Ligand General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T57613 Target Info
Target Name TWIK-related acid-sensitive potassium channel 3 (TASK3)
Synonyms Two pore potassium channel KT3.2; TWIK-related acid-sensitive K+ channel 3; KCNK9; Acid-sensitive potassium channel protein TASK-3
Target Type Literature-reported Target
Gene Name KCNK9
UniProt ID
KCNK9_HUMAN
Ligand General Information  Top
Ligand Name Fusicoccin Ligand Info
Canonical SMILES CC1C2CCC(C2=CC3(C(CC(=C3C(C1O)OC4C(C(C(C(O4)COC(C)(C)C=C)O)OC(=O)C)O)C(C)COC(=O)C)O)C)COC
InChI 1S/C36H56O12/c1-10-35(6,7)45-17-26-30(41)33(46-21(5)38)31(42)34(47-26)48-32-28-24(18(2)15-44-20(4)37)13-27(39)36(28,8)14-25-22(16-43-9)11-12-23(25)19(3)29(32)40/h10,14,18-19,22-23,26-27,29-34,39-42H,1,11-13,15-17H2,2-9H3/b25-14-/t18-,19-,22-,23+,26-,27+,29-,30-,31-,32-,33+,34-,36+/m1/s1
InChIKey KXTYBXCEQOANSX-WYKQKOHHSA-N
PubChem Compound ID 447573
Drug Binding Sites of Target  Top
PDB ID: 3P1S      Crystal structure of human 14-3-3 sigma C38N/N166H in complex with TASK-3 peptide and stabilizer fusicoccin A
Method X-ray diffraction Resolution 1.65 Å Mutation Yes [1]
PDB Sequence
KRRKV
Residue
Distance (Å)
VAL374
3.875
Residue
Distance (Å)
PDB ID: 3P1Q      Crystal structure of human 14-3-3 sigma C38N/N166H in complex with TASK-3 Peptide and stabilizer fusicoccin A
Method X-ray diffraction Resolution 1.70 Å Mutation Yes [1]
PDB Sequence
KRRKV
Residue
Distance (Å)
VAL374
3.887
Residue
Distance (Å)
PDB ID: 3P1O      Crystal structure of human 14-3-3 sigma in complex with TASK-3 peptide and stabilisator Fusicoccin A
Method X-ray diffraction Resolution 1.90 Å Mutation No [1]
PDB Sequence
KRRKV
Residue
Distance (Å)
VAL374
3.955
Residue
Distance (Å)
References  Top
REF 1 A semisynthetic fusicoccane stabilizes a protein-protein interaction and enhances the expression of K+ channels at the cell surface. Chem Biol. 2013 Apr 18;20(4):583-93.

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