Target Binding Site Detail

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Target General Information
Ligand General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T57613 Target Info
Target Name TWIK-related acid-sensitive potassium channel 3 (TASK3)
Synonyms Two pore potassium channel KT3.2; TWIK-related acid-sensitive K+ channel 3; KCNK9; Acid-sensitive potassium channel protein TASK-3
Target Type Literature-reported Target
Gene Name KCNK9
UniProt ID
KCNK9_HUMAN
Ligand General Information  Top
Ligand Name Fusicoccin J Aglycone Ligand Info
Canonical SMILES CC1C2CCC(C2=CC3(C(CC(=C3C(C1O)O)C(C)C)O)C)COC
InChI 1S/C21H34O4/c1-11(2)15-8-17(22)21(4)9-16-13(10-25-5)6-7-14(16)12(3)19(23)20(24)18(15)21/h9,11-14,17,19-20,22-24H,6-8,10H2,1-5H3/b16-9-/t12-,13-,14+,17+,19-,20-,21+/m1/s1
InChIKey YZZBBYUVOSVRJT-KFPAJSSTSA-N
PubChem Compound ID 57345900
Drug Binding Sites of Target  Top
PDB ID: 3SMO      Crystal structure of human 14-3-3 sigma C38V/N166H in complex with TASK-3 peptide and stabilizer Fusicoccin J aglycone
Method X-ray diffraction Resolution 1.80 Å Mutation Yes [1]
PDB Sequence
KRRKV
Residue
Distance (Å)
VAL374
3.870
Residue
Distance (Å)
PDB ID: 3SMM      Crystal structure of human 14-3-3 sigma C38N/N166H in complex with task-3 peptide and stabilizer Fusicoccin J aglycone
Method X-ray diffraction Resolution 2.00 Å Mutation Yes [1]
PDB Sequence
KRRKV
Residue
Distance (Å)
VAL374
3.880
Residue
Distance (Å)
References  Top
REF 1 A semisynthetic fusicoccane stabilizes a protein-protein interaction and enhances the expression of K+ channels at the cell surface. Chem Biol. 2013 Apr 18;20(4):583-93.

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