Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T53952 | Target Info | |||
| Target Name | Homeodomain interacting protein kinase 2 (HIPK2) | ||||
| Synonyms | hHIPk2; Homeodomain-interacting protein kinase 2 | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | HIPK2 | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | L-serine-O-phosphate | Ligand Info | |||
| Canonical SMILES | C(C(C(=O)O)N)OP(=O)(O)O | ||||
| InChI | 1S/C3H8NO6P/c4-2(3(5)6)1-10-11(7,8)9/h2H,1,4H2,(H,5,6)(H2,7,8,9)/t2-/m0/s1 | ||||
| InChIKey | BZQFBWGGLXLEPQ-REOHCLBHSA-N | ||||
| PubChem Compound ID | 68841 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 6P5S HIPK2 kinase domain bound to CX-4945 | ||||||
| Method | X-ray diffraction | Resolution | 2.19 Å | Mutation | No | [1] |
| PDB Sequence |
QLVQHEVLCS
194 MTNTYEVLEF204 LGRGQVVKCW217 KRGTNEIVAI227 KILRQGQIEV244 SILARLSTES 254 ADDYNFVRAY264 ECFQHHTCLV276 FEMLEQNLYD286 FLKQNKFSPL296 PLKYIRPVLQ 306 QVATALMKLK316 SLGLIHADLK326 PENIMLVDPS336 RQPYRVKVID346 FGSASHVTLQ 363 SRYYRAPEII373 LGLPFCEAID383 MWSLGCVIAE393 LFLGWPLYPG403 ASEYDQIRYI 413 SQTQGLPAEY423 LLSAGTKTTR433 FFNRDTDPYP444 LWRLKTPDDH454 EAETGIKSKE 464 ARKYIFNCLD474 DMAQVNMTTD484 LEGSDMLVEK494 ADRREFIDLL504 KKMLTIDADK 514 RITPIETLNH524 PFVTMTHLLD534 F
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| PDB ID: 7NCF Crystal structure of HIPK2 in complex with MU135 (compound 21e) | ||||||
| Method | X-ray diffraction | Resolution | 2.72 Å | Mutation | No | [2] |
| PDB Sequence |
SMDYQLVQHE
190 VLCSMTNTYE200 VLEFLGRGTF210 GQVVKCWKRG220 TNEIVAIKIL230 KNHPSYARQG 240 QIEVSILARL250 STESADDYNF260 VRAYECFQHK270 NHTCLVFEML280 EQNLYDFLKQ 290 NKFSPLPLKY300 IRPVLQQVAT310 ALMKLKSLGL320 IHADLKPENI330 MLVDPSRQPY 340 RVKVIDFGSA350 SHVSKAVCST360 LQSRYYRAPE371 IILGLPFCEA381 IDMWSLGCVI 391 AELFLGWPLY401 PGASEYDQIR411 YISQTQGLPA421 EYLLSAGTKT431 TRFFNRDTDP 442 YPLWRLKTPD452 DHEAETGIKS462 KEARKYIFNC472 LDDMAQVNMT482 TDLEGSDMLV 492 EKADRREFID502 LLKKMLTIDA512 DKRITPIETL522 NHPFVTMTHL532 LDF |
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | The crystal structure of the protein kinase HIPK2 reveals a unique architecture of its CMGC-insert region. J Biol Chem. 2019 Sep 13;294(37):13545-13559. | ||||
| REF 2 | Highly selective inhibitors of protein kinases CLK and HIPK with the furo[3,2-b]pyridine core. Eur J Med Chem. 2021 Apr 5;215:113299. | ||||
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