Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T53159 | Target Info | |||
| Target Name | ERK activator kinase 7 (MAP2K7) | ||||
| Synonyms | Stress-activated protein kinase kinase 4; SKK4; SAPKK4; SAPKK-4; SAPK kinase 4; PRKMK7; Mitogen-activated protein kinase kinase 7; MKK7; MEK7; MEK 7; MAPKK 7; MAPK/ERK kinase7; MAPK/ERK kinase 7; MAP kinase kinase 7; JNKK2; JNKK 2; JNK-activating kinase 2; JNK kinase 2; JNK activating kinase 2; Dual specificity mitogen-activated protein kinase kinase 7; C-Jun N-terminal kinase kinase 2 | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | MAP2K7 | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | Cysteine Sulfenic Acid | Ligand Info | |||
| Canonical SMILES | C(C(C(=O)O)N)SO | ||||
| InChI | 1S/C3H7NO3S/c4-2(1-8-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1 | ||||
| InChIKey | FXIRVRPOOYSARH-REOHCLBHSA-N | ||||
| PubChem Compound ID | 165339 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 6YG4 Crystal structure of MKK7 (MAP2K7) in complex with K00007 | ||||||
| Method | X-ray diffraction | Resolution | 2.30 Å | Mutation | No | [1] |
| PDB Sequence |
TGYLTIGGQR
128 YQAEINDLEN138 LGEMGQVWKM153 RFRKTGHVIA163 VKQMRRSGNK173 EENKRILMDL 183 DVVLKSHDCP193 YIVQCFGTFI203 TNTDVFIAME213 LMGTAEKLKK224 RMQGPIPERI 234 LGKMTVAIVK244 ALYYLKEKHG254 VIHRDVKPSN264 ILLDERGQIK274 LDFGISGIRA 319 DVWSLGISLV329 ELATGQFPYK339 NCKTDFEVLT349 KVLQEEPPLL359 PGHMGFSGDF 369 QSFVKDCLTK379 DHRKRPKYNK389 LLEHSFIKRY399 ETLEVDVASW409 FKDVMAKT |
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| PDB ID: 6YG5 Crystal structure of MKK7 (MAP2K7) in complex with ASC69 | ||||||
| Method | X-ray diffraction | Resolution | 2.40 Å | Mutation | No | [1] |
| PDB Sequence |
KQTGYLTIGG
126 QRYQAEINDL136 ENLGEMGGQV150 WKMRFRKTGH160 VIAVKQMRRS170 GNKEENKRIL 180 MDLDVVLKSH190 DCPYIVQCFG200 TFITNTDVFI210 AMELMGTAEK221 LKKRMQGPIP 231 ERILGKMTVA241 IVKALYYLKE251 KHGVIHRDVK261 PSNILLDERG271 QIKLDFGISG 282 DVWSLGISLV329 ELATGQFPYK339 NCKTDFEVLT349 KVLQEEPPLL359 PGHMGFSGDF 369 QSFVKDCLTK379 DHRKRPKYNK389 LLEHSFIKRY399 ETLEVDVASW409 FKDVMAKTES 419
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Catalytic Domain Plasticity of MKK7 Reveals Structural Mechanisms of Allosteric Activation and Diverse Targeting Opportunities. Cell Chem Biol. 2020 Oct 15;27(10):1285-1295.e4. | ||||
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