Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T31406 | Target Info | |||
| Target Name | Hematopoietic cell kinase (HCK) | ||||
| Synonyms | p61Hck; p59Hck; p59-HCK/p60-HCK; Tyrosine-protein kinase HCK; Hemopoietic cell kinase | ||||
| Target Type | Patented-recorded Target | ||||
| Gene Name | HCK | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | Phosphonotyrosine | Ligand Info | |||
| Canonical SMILES | C1=CC(=CC=C1CC(C(=O)O)N)OP(=O)(O)O | ||||
| InChI | 1S/C9H12NO6P/c10-8(9(11)12)5-6-1-3-7(4-2-6)16-17(13,14)15/h1-4,8H,5,10H2,(H,11,12)(H2,13,14,15)/t8-/m0/s1 | ||||
| InChIKey | DCWXELXMIBXGTH-QMMMGPOBSA-N | ||||
| PubChem Compound ID | 30819 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 5H0B Crystal structure of HCK complexed with a pyrrolo-pyrimidine inhibitor (S)-2-(((1r,4S)-4-(4-amino-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclohexyl)amino)-4-methylpentanoic acid | ||||||
| Method | X-ray diffraction | Resolution | 1.65 Å | Mutation | Yes | [1] |
| PDB Sequence |
RIIVVALYDY
94 EAIHHEDLSF104 QKGDQMVVLE114 ESGEWWKARS124 LATRKEGYIP134 SNYVARVDSL 144 ETEEWFFKGI154 SRKDAERQLL164 APGNMLGSFM174 IRDSETTKGS184 YSLSVRDYDP 194 RQGDTVKHYK204 IRTLDNGGFY214 ISPRSTFSTL224 QELVDHYKKG234 NDGLCQKLSV 244 PCMSSKPQKP254 WEKDAWEIPR264 ESLKLEKKLG274 AGQFGEVWMA284 TYNKHTKVAV 294 KTMKPGSMSV304 EAFLAEANVM314 KTLQHDKLVK324 LHAVVTKEPI334 YIITEFMAKG 344 SLLDFLKSDE354 GSKQPLPKLI364 DFSAQIAEGM374 AFIEQRNYIH384 RDLRAANILV 394 SASLVCKIAD404 FGLARVIEDN414 EYTAREGAKF424 PIKWTAPEAI434 NFGSFTIKSD 444 VWSFGILLME454 IVTYGRIPYP464 GMSNPEVIRA474 LERGYRMPRP484 ENCPEELYNI 494 MMRCWKNRPE504 ERPTFEYIQS514 VLDDFYTATE524 SQEEIP
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| PDB ID: 5H0H Crystal structure of HCK complexed with a pyrrolo-pyrimidine inhibitor (S)-2-(((1r,4S)-4-(4-amino-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclohexyl)amino)-N,N,4-trimethylpentanamide | ||||||
| Method | X-ray diffraction | Resolution | 1.72 Å | Mutation | Yes | [1] |
| PDB Sequence |
RIIVVALYDY
94 EAIHHEDLSF104 QKGDQMVVLE114 ESGEWWKARS124 LATRKEGYIP134 SNYVARVDSL 144 ETEEWFFKGI154 SRKDAERQLL164 APGNMLGSFM174 IRDSETTKGS184 YSLSVRDYDP 194 RQGDTVKHYK204 IRTLDNGGFY214 ISPRSTFSTL224 QELVDHYKKG234 NDGLCQKLSV 244 PCMSSKPQKP254 WEKDAWEIPR264 ESLKLEKKLG274 AGQFGEVWMA284 TYNKHTKVAV 294 KTMKPGSMSV304 EAFLAEANVM314 KTLQHDKLVK324 LHAVVTKEPI334 YIITEFMAKG 344 SLLDFLKSDE354 GSKQPLPKLI364 DFSAQIAEGM374 AFIEQRNYIH384 RDLRAANILV 394 SASLVCKIAD404 FGLARVIEDN414 EYTAREGAKF424 PIKWTAPEAI434 NFGSFTIKSD 444 VWSFGILLME454 IVTYGRIPYP464 GMSNPEVIRA474 LERGYRMPRP484 ENCPEELYNI 494 MMRCWKNRPE504 ERPTFEYIQS514 VLDDFYTATE524 SQEEIP
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| PDB ID: 5H0G Crystal structure of HCK complexed with a pyrrolo-pyrimidine inhibitor (S)-2-(((1r,4S)-4-(4-amino-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclohexyl)amino)-N,4-dimethylpentanamide | ||||||
| Method | X-ray diffraction | Resolution | 1.80 Å | Mutation | Yes | [1] |
| PDB Sequence |
RIIVVALYDY
94 EAIHHEDLSF104 QKGDQMVVLE114 ESGEWWKARS124 LATRKEGYIP134 SNYVARVDSL 144 ETEEWFFKGI154 SRKDAERQLL164 APGNMLGSFM174 IRDSETTKGS184 YSLSVRDYDP 194 RQGDTVKHYK204 IRTLDNGGFY214 ISPRSTFSTL224 QELVDHYKKG234 NDGLCQKLSV 244 PCMSSKPQKP254 WEKDAWEIPR264 ESLKLEKKLG274 AGQFGEVWMA284 TYNKHTKVAV 294 KTMKPGSMSV304 EAFLAEANVM314 KTLQHDKLVK324 LHAVVTKEPI334 YIITEFMAKG 344 SLLDFLKSDE354 GSKQPLPKLI364 DFSAQIAEGM374 AFIEQRNYIH384 RDLRAANILV 394 SASLVCKIAD404 FGLARVIEDN414 EYTAREGAKF424 PIKWTAPEAI434 NFGSFTIKSD 444 VWSFGILLME454 IVTYGRIPYP464 GMSNPEVIRA474 LERGYRMPRP484 ENCPEELYNI 494 MMRCWKNRPE504 ERPTFEYIQS514 VLDDFYTATE524 SQEEIP
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| PDB ID: 5H09 Crystal structure of HCK complexed with a pyrrolo-pyrimidine inhibitor (S)-ethyl2-(((1r,4S)-4-(4-amino-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclohexyl)amino)-4-methylpentanoate | ||||||
| Method | X-ray diffraction | Resolution | 1.95 Å | Mutation | Yes | [1] |
| PDB Sequence |
RIIVVALYDY
94 EAIHHEDLSF104 QKGDQMVVLE114 ESGEWWKARS124 LATRKEGYIP134 SNYVARVDSL 144 ETEEWFFKGI154 SRKDAERQLL164 APGNMLGSFM174 IRDSETTKGS184 YSLSVRDYDP 194 RQGDTVKHYK204 IRTLDNGGFY214 ISPRSTFSTL224 QELVDHYKKG234 NDGLCQKLSV 244 PCMSSKPQKP254 WEKDAWEIPR264 ESLKLEKKLG274 AGQFGEVWMA284 TYNKHTKVAV 294 KTMKPGSMSV304 EAFLAEANVM314 KTLQHDKLVK324 LHAVVTKEPI334 YIITEFMAKG 344 SLLDFLKSDE354 GSKQPLPKLI364 DFSAQIAEGM374 AFIEQRNYIH384 RDLRAANILV 394 SASLVCKIAD404 FGLARVIEDN414 EYTAREGAKF424 PIKWTAPEAI434 NFGSFTIKSD 444 VWSFGILLME454 IVTYGRIPYP464 GMSNPEVIRA474 LERGYRMPRP484 ENCPEELYNI 494 MMRCWKNRPE504 ERPTFEYIQS514 VLDDFYTATE524 SQEEIP
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .PTR or .PTR2 or .PTR3 or :3PTR;style chemicals stick;color identity;select .A:156 or .A:176 or .A:177 or .A:178 or .A:179 or .A:180 or .A:186 or .A:202 or .A:203 or .A:204 or .A:525 or .A:526 or .A:528 or .A:529; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| PDB ID: 1QCF CRYSTAL STRUCTURE OF HCK IN COMPLEX WITH A SRC FAMILY-SELECTIVE TYROSINE KINASE INHIBITOR | ||||||
| Method | X-ray diffraction | Resolution | 2.00 Å | Mutation | Yes | [2] |
| PDB Sequence |
SGIRIIVVAL
89 YDYEAIHHED99 LSFQKGDQMV109 VLEESGEWWK120 ARSLATRKEG130 YIPSNYVARV 140 DSLETEEWFF150 KGISRKDAER160 QLLAPGNMLG170 SFMIRDSETT180 KGSYSLSVRD 190 YDPRQGDTVK200 HYKIRTLDNG210 GFYISPRSTF220 STLQELVDHY230 KKGNDGLCQK 240 LSVPCMSSKP250 QKPWEKDAWE261 IPRESLKLEK271 KLGAGQFGEV281 WMATYNKHTK 291 VAVKTMKPGS301 MSVEAFLAEA311 NVMKTLQHDK321 LVKLHAVVTK331 EPIYIITEFM 341 AKGSLLDFLK351 SDEGSKQPLP361 KLIDFSAQIA371 EGMAFIEQRN381 YIHRDLRAAN 391 ILVSASLVCK401 IADFGLARVI411 EDNEYTAREG421 AKFPIKWTAP431 EAINFGSFTI 441 KSDVWSFGIL451 LMEIVTYGRI461 PYPGMSNPEV471 IRALERGYRM481 PRPENCPEEL 491 YNIMMRCWKN501 RPEERPTFEY511 IQSVLDDFYT521 ATESQEEIP
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .PTR or .PTR2 or .PTR3 or :3PTR;style chemicals stick;color identity;select .A:155 or .A:175 or .A:176 or .A:177 or .A:178 or .A:179 or .A:185 or .A:201 or .A:202 or .A:203 or .A:525 or .A:526 or .A:528 or .A:529; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| PDB ID: 5H0E Crystal structure of HCK complexed with a pyrrolo-pyrimidine inhibitor (S)-2-(((1r,4S)-4-(4-amino-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclohexyl)amino)-4-methylpentanamide | ||||||
| Method | X-ray diffraction | Resolution | 2.10 Å | Mutation | Yes | [1] |
| PDB Sequence |
RIIVVALYDY
94 EAIHHEDLSF104 QKGDQMVVLE114 ESGEWWKARS124 LATRKEGYIP134 SNYVARVDSL 144 ETEEWFFKGI154 SRKDAERQLL164 APGNMLGSFM174 IRDSETTKGS184 YSLSVRDYDP 194 RQGDTVKHYK204 IRTLDNGGFY214 ISPRSTFSTL224 QELVDHYKKG234 NDGLCQKLSV 244 PCMSSKPQKP254 WEKDAWEIPR264 ESLKLEKKLG274 AGQFGEVWMA284 TYNKHTKVAV 294 KTMKPGSMSV304 EAFLAEANVM314 KTLQHDKLVK324 LHAVVTKEPI334 YIITEFMAKG 344 SLLDFLKSDE354 GSKQPLPKLI364 DFSAQIAEGM374 AFIEQRNYIH384 RDLRAANILV 394 SASLVCKIAD404 FGLARVIEDN414 EYTAREGAKF424 PIKWTAPEAI434 NFGSFTIKSD 444 VWSFGILLME454 IVTYGRIPYP464 GMSNPEVIRA474 LERGYRMPRP484 ENCPEELYNI 494 MMRCWKNRPE504 ERPTFEYIQS514 VLDDFYTATE524 SQEEIP
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .PTR or .PTR2 or .PTR3 or :3PTR;style chemicals stick;color identity;select .A:156 or .A:176 or .A:177 or .A:178 or .A:179 or .A:180 or .A:186 or .A:202 or .A:203 or .A:204 or .A:525 or .A:526 or .A:528 or .A:529; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| PDB ID: 2C0T Src family kinase Hck with bound inhibitor A-641359 | ||||||
| Method | X-ray diffraction | Resolution | 2.15 Å | Mutation | Yes | [3] |
| PDB Sequence |
RIIVVALYDY
68 EAIHHEDLSF78 QKGDQMVVLE88 ESGEWWKARS98 LATRKEGYIP108 SNYVARVDSL 118 ETEEWFFKGI128 SRKDAERQLL138 APGNMLGSFM148 IRDSETTKGS158 YSLSVRDYDP 168 RQGDTVKHYK178 IRFYISPRST194 FSTLQELVDH204 YKKGNDGLCQ214 KLSVPCMSSK 224 PQKPWEKDAW234 EIPRESLKLE244 KKLGAGQFGE254 VWMATYNKHT264 KVAVKTMKPG 274 SMSVEAFLAE284 ANVMKTLQHD294 KLVKLHAVVT304 KEPIYIITEF314 MAKGSLLDFL 324 KSDEGSKQPL334 PKLIDFSAQI344 AEGMAFIEQR354 NYIHRDLRAA364 NILVSASLVC 374 KIADFGLARV384 IPIKWTAPEA407 INFGSFTIKS417 DVWSFGILLM427 EIVTYGRIPY 437 PGMSNPEVIR447 ALERGYRMPR457 PENCPEELYN467 IMMRCWKNRP477 EERPTFEYIQ 487 SVLDDFYTAT497 ESQEEIP
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .PTR or .PTR2 or .PTR3 or :3PTR;style chemicals stick;color identity;select .A:130 or .A:150 or .A:151 or .A:152 or .A:153 or .A:154 or .A:155 or .A:160 or .A:176 or .A:177 or .A:178 or .A:498 or .A:499 or .A:500 or .A:502 or .A:503; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| PDB ID: 3VS3 Crystal structure of HCK complexed with a pyrrolo-pyrimidine inhibitor 7-[trans-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine | ||||||
| Method | X-ray diffraction | Resolution | 2.17 Å | Mutation | Yes | [4] |
| PDB Sequence |
RIIVVALYDY
94 EAIHHEDLSF104 QKGDQMVVLE114 ESGEWWKARS124 LATRKEGYIP134 SNYVARVDSL 144 ETEEWFFKGI154 SRKDAERQLL164 APGNMLGSFM174 IRDSETTKGS184 YSLSVRDYDP 194 RQGDTVKHYK204 IRTLDNGGFY214 ISPRSTFSTL224 QELVDHYKKG234 NDGLCQKLSV 244 PCMSSKPQKP254 WEKDAWEIPR264 ESLKLEKKLG274 AGQFGEVWMA284 TYNKHTKVAV 294 KTMKPGSMSV304 EAFLAEANVM314 KTLQHDKLVK324 LHAVVTKEPI334 YIITEFMAKG 344 SLLDFLKSDE354 GSKQPLPKLI364 DFSAQIAEGM374 AFIEQRNYIH384 RDLRAANILV 394 SASLVCKIAD404 FGLARVIFPI426 KWTAPEAINF436 GSFTIKSDVW446 SFGILLMEIV 456 TYGRIPYPGM466 SNPEVIRALE476 RGYRMPRPEN486 CPEELYNIMM496 RCWKNRPEER 506 PTFEYIQSVL516 DDFYTATESQ526 EEIP
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .PTR or .PTR2 or .PTR3 or :3PTR;style chemicals stick;color identity;select .A:156 or .A:176 or .A:177 or .A:178 or .A:179 or .A:180 or .A:181 or .A:186 or .A:202 or .A:203 or .A:204 or .A:524 or .A:525 or .A:526 or .A:528 or .A:529; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| PDB ID: 3VRZ Crystal structure of HCK complexed with a pyrrolo-pyrimidine inhibitor 1-[4-(4-amino-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)phenyl]-3-benzylurea | ||||||
| Method | X-ray diffraction | Resolution | 2.22 Å | Mutation | Yes | [4] |
| PDB Sequence |
RIIVVALYDY
94 EAIHHEDLSF104 QKGDQMVVLE114 ESGEWWKARS124 LATRKEGYIP134 SNYVARVDSL 144 ETEEWFFKGI154 SRKDAERQLL164 APGNMLGSFM174 IRDSETTKGS184 YSLSVRDYDP 194 RQGDTVKHYK204 IRTGFYISPR218 STFSTLQELV228 DHYKKGNDGL238 CQKLSVPCMS 248 SKPQKPWEKD258 AWEIPRESLK268 LEKKLGAGQF278 GEVWMATYNK288 HTKVAVKTMK 298 PGSMSVEAFL308 AEANVMKTLQ318 HDKLVKLHAV328 VTKEPIYIIT338 EFMAKGSLLD 348 FLKSDEGSKQ358 PLPKLIDFSA368 QIAEGMAFIE378 QRNYIHRDLR388 AANILVSASL 398 VCKIADFGLA408 RVIPIKWTAP431 EAINFGSFTI441 KSDVWSFGIL451 LMEIVTYGRI 461 PYPGMSNPEV471 IRALERGYRM481 PRPENCPEEL491 YNIMMRCWKN501 RPEERPTFEY 511 IQSVLDDFYT521 ATESQEEIP
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .PTR or .PTR2 or .PTR3 or :3PTR;style chemicals stick;color identity;select .A:156 or .A:176 or .A:177 or .A:178 or .A:179 or .A:180 or .A:181 or .A:186 or .A:202 or .A:203 or .A:204 or .A:524 or .A:525 or .A:526 or .A:528 or .A:529; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| PDB ID: 2C0I Src family kinase Hck with bound inhibitor A-420983 | ||||||
| Method | X-ray diffraction | Resolution | 2.30 Å | Mutation | Yes | [3] |
| PDB Sequence |
RIIVVALYDY
68 EAIHHEDLSF78 QKGDQMVVLE88 ESGEWWKARS98 LATRKEGYIP108 SNYVARVDSL 118 ETEEWFFKGI128 SRKDAERQLL138 APGNMLGSFM148 IRDSETTKGS158 YSLSVRDYDP 168 RQGDTVKHYK178 IRTLDNGGFY188 ISPRSTFSTL198 QELVDHYKKG208 NDGLCQKLSV 218 PCMSSKPQKP228 WEKDAWEIPR238 ESLKLEKKLG248 AGQFGEVWMA258 TYNKHTKVAV 268 KTMKPGSMSV278 EAFLAEANVM288 KTLQHDKLVK298 LHAVVTKEPI308 YIITEFMAKG 318 SLLDFLKSDE328 GSKQPLPKLI338 DFSAQIAEGM348 AFIEQRNYIH358 RDLRAANILV 368 SASLVCKIAD378 FGLARVIPIK401 WTAPEAINFG411 SFTIKSDVWS421 FGILLMEIVT 431 YGRIPYPGMS441 NPEVIRALER451 GYRMPRPENC461 PEELYNIMMR471 CWKNRPEERP 481 TFEYIQSVLD491 DFYTATESQE502 EIP
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .PTR or .PTR2 or .PTR3 or :3PTR;style chemicals stick;color identity;select .A:130 or .A:150 or .A:151 or .A:152 or .A:153 or .A:154 or .A:155 or .A:160 or .A:176 or .A:177 or .A:178 or .A:497 or .A:498 or .A:499 or .A:500 or .A:502 or .A:503; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| PDB ID: 3VS6 Crystal structure of HCK complexed with a pyrazolo-pyrimidine inhibitor tert-butyl {4-[4-amino-1-(propan-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-2-methoxyphenyl}carbamate | ||||||
| Method | X-ray diffraction | Resolution | 2.37 Å | Mutation | Yes | [4] |
| PDB Sequence |
RIIVVALYDY
94 EAIHHEDLSF104 QKGDQMVVLE114 ESGEWWKARS124 LATRKEGYIP134 SNYVARVDSL 144 ETEEWFFKGI154 SRKDAERQLL164 APGNMLGSFM174 IRDSETTKGS184 YSLSVRDYDP 194 RQGDTVKHYK204 IRTLDNGGFY214 ISPRSTFSTL224 QELVDHYKKG234 NDGLCQKLSV 244 PCMSSKPQKP254 WEKDAWEIPR264 ESLKLEKKLG274 AGQFGEVWMA284 TYNKHTKVAV 294 KTMKPGSMSV304 EAFLAEANVM314 KTLQHDKLVK324 LHAVVTKEPI334 YIITEFMAKG 344 SLLDFLKSDE354 GSKQPLPKLI364 DFSAQIAEGM374 AFIEQRNYIH384 RDLRAANILV 394 SASLVCKIAD404 FGLARVIFPI426 KWTAPEAINF436 GSFTIKSDVW446 SFGILLMEIV 456 TYGRIPYPGM466 SNPEVIRALE476 RGYRMPRPEN486 CPEELYNIMM496 RCWKNRPEER 506 PTFEYIQSVL516 DDFYTATESQ526 EEIP
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .PTR or .PTR2 or .PTR3 or :3PTR;style chemicals stick;color identity;select .A:156 or .A:176 or .A:177 or .A:178 or .A:179 or .A:180 or .A:181 or .A:186 or .A:202 or .A:203 or .A:204 or .A:524 or .A:525 or .A:526 or .A:528 or .A:529; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| PDB ID: 3VS1 Crystal structure of HCK complexed with a pyrrolo-pyrimidine inhibitor 1-[4-(4-amino-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)phenyl]-3-phenylurea | ||||||
| Method | X-ray diffraction | Resolution | 2.46 Å | Mutation | Yes | [4] |
| PDB Sequence |
RIIVVALYDY
94 EAIHHEDLSF104 QKGDQMVVLE114 ESGEWWKARS124 LATRKEGYIP134 SNYVARVDSL 144 ETEEWFFKGI154 SRKDAERQLL164 APGNMLGSFM174 IRDSETTKGS184 YSLSVRDYDP 194 RQGDTVKHYK204 IRSPRSTFST223 LQELVDHYKK233 GNDGLCQKLS243 VPCMSSKPQK 253 PWEKDAWEIP263 RESLKLEKKL273 GAGQFGEVWM283 ATYNKHTKVA293 VKTMKPGSMS 303 VEAFLAEANV313 MKTLQHDKLV323 KLHAVVTKEP333 IYIITEFMAK343 GSLLDFLKSD 353 EGSKQPLPKL363 IDFSAQIAEG373 MAFIEQRNYI383 HRDLRAANIL393 VSASLVCKIA 403 DFGLARVIPI426 KWTAPEAINF436 GSFTIKSDVW446 SFGILLMEIV456 TYGRIPYPGM 466 SNPEVIRALE476 RGYRMPRPEN486 CPEELYNIMM496 RCWKNRPEER506 PTFEYIQSVL 516 DDFYTATESQ526 EEIP
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .PTR or .PTR2 or .PTR3 or :3PTR;style chemicals stick;color identity;select .A:156 or .A:176 or .A:177 or .A:178 or .A:179 or .A:180 or .A:181 or .A:186 or .A:202 or .A:203 or .A:204 or .A:524 or .A:525 or .A:526 or .A:528 or .A:529; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| PDB ID: 3VRY Crystal structure of HCK complexed with a pyrrolo-pyrimidine inhibitor 4-Amino-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl-cyclopentane | ||||||
| Method | X-ray diffraction | Resolution | 2.48 Å | Mutation | Yes | [4] |
| PDB Sequence |
RIIVVALYDY
94 EAIHHEDLSF104 QKGDQMVVLE114 ESGEWWKARS124 LATRKEGYIP134 SNYVARVDSL 144 ETEEWFFKGI154 SRKDAERQLL164 APGNMLGSFM174 IRDSETTKGS184 YSLSVRDYDP 194 RQGDTVKHYK204 IRFYISPRST220 FSTLQELVDH230 YKKGNDGLCQ240 KLSVPCMSSK 250 PQKPWEKDAW260 EIPRESLKLE270 KKLGAGQFGE280 VWMATYNKHT290 KVAVKTMKPG 300 SMSVEAFLAE310 ANVMKTLQHD320 KLVKLHAVVT330 KEPIYIITEF340 MAKGSLLDFL 350 KSDEGSKQPL360 PKLIDFSAQI370 AEGMAFIEQR380 NYIHRDLRAA390 NILVSASLVC 400 KIADFGLARV410 IFPIKWTAPE432 AINFGSFTIK442 SDVWSFGILL452 MEIVTYGRIP 462 YPGMSNPEVI472 RALERGYRMP482 RPENCPEELY492 NIMMRCWKNR502 PEERPTFEYI 512 QSVLDDFYTA522 TESQEEIP
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .PTR or .PTR2 or .PTR3 or :3PTR;style chemicals stick;color identity;select .A:156 or .A:176 or .A:177 or .A:178 or .A:179 or .A:180 or .A:181 or .A:186 or .A:202 or .A:203 or .A:204 or .A:523 or .A:524 or .A:525 or .A:526 or .A:528 or .A:529; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| PDB ID: 3VS2 Crystal structure of HCK complexed with a pyrrolo-pyrimidine inhibitor 7-[cis-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine | ||||||
| Method | X-ray diffraction | Resolution | 2.61 Å | Mutation | Yes | [4] |
| PDB Sequence |
RIIVVALYDY
94 EAIHHEDLSF104 QKGDQMVVLE114 ESGEWWKARS124 LATRKEGYIP134 SNYVARVDSL 144 ETEEWFFKGI154 SRKDAERQLL164 APGNMLGSFM174 IRDSETTKGS184 YSLSVRDYDP 194 RQGDTVKHYK204 IRTLGFYISP217 RSTFSTLQEL227 VDHYKKGNDG237 LCQKLSVPCM 247 SSKPQKPWEK257 DAWEIPRESL267 KLEKKLGAGQ277 FGEVWMATYN287 KHTKVAVKTM 297 KPGSMSVEAF307 LAEANVMKTL317 QHDKLVKLHA327 VVTKEPIYII337 TEFMAKGSLL 347 DFLKSDEGSK357 QPLPKLIDFS367 AQIAEGMAFI377 EQRNYIHRDL387 RAANILVSAS 397 LVCKIADFGL407 ARVIPIKWTA430 PEAINFGSFT440 IKSDVWSFGI450 LLMEIVTYGR 460 IPYPGMSNPE470 VIRALERGYR480 MPRPENCPEE490 LYNIMMRCWK500 NRPEERPTFE 510 YIQSVLDDFY520 TATESQEEIP531
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .PTR or .PTR2 or .PTR3 or :3PTR;style chemicals stick;color identity;select .A:156 or .A:176 or .A:177 or .A:178 or .A:179 or .A:180 or .A:181 or .A:186 or .A:202 or .A:203 or .A:204 or .A:524 or .A:525 or .A:526 or .A:528 or .A:529; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| PDB ID: 3VS4 Crystal structure of HCK complexed with a pyrrolo-pyrimidine inhibitor 5-(4-phenoxyphenyl)-7-(tetrahydro-2H-pyran-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine | ||||||
| Method | X-ray diffraction | Resolution | 2.75 Å | Mutation | Yes | [4] |
| PDB Sequence |
RIIVVALYDY
94 EAIHHEDLSF104 QKGDQMVVLE114 ESGEWWKARS124 LATRKEGYIP134 SNYVARVDSL 144 ETEEWFFKGI154 SRKDAERQLL164 APGNMLGSFM174 IRDSETTKGS184 YSLSVRDYDP 194 RQGDTVKHYK204 IRFYISPRST220 FSTLQELVDH230 YKKGNDGLCQ240 KLSVPCMSSK 250 PQKPWEKDAW260 EIPRESLKLE270 KKLGAGQFGE280 VWMATYNKHT290 KVAVKTMKPG 300 SMSVEAFLAE310 ANVMKTLQHD320 KLVKLHAVVT330 KEPIYIITEF340 MAKGSLLDFL 350 KSDEGSKQPL360 PKLIDFSAQI370 AEGMAFIEQR380 NYIHRDLRAA390 NILVSASLVC 400 KIADFGLARV410 IEFPIKWTAP431 EAINFGSFTI441 KSDVWSFGIL451 LMEIVTYGRI 461 PYPGMSNPEV471 IRALERGYRM481 PRPENCPEEL491 YNIMMRCWKN501 RPEERPTFEY 511 IQSVLDDFYT521 ATESQEEIP
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .PTR or .PTR2 or .PTR3 or :3PTR;style chemicals stick;color identity;select .A:156 or .A:176 or .A:177 or .A:178 or .A:179 or .A:180 or .A:181 or .A:186 or .A:202 or .A:203 or .A:204 or .A:524 or .A:525 or .A:526 or .A:528 or .A:529; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| PDB ID: 2C0O Src family kinase Hck with bound inhibitor A-770041 | ||||||
| Method | X-ray diffraction | Resolution | 2.85 Å | Mutation | Yes | [3] |
| PDB Sequence |
RIIVVALYDY
68 EAIHHEDLSF78 QKGDQMVVLE88 ESGEWWKARS98 LATRKEGYIP108 SNYVARVDSL 118 ETEEWFFKGI128 SRKDAERQLL138 APGNMLGSFM148 IRDSETTKGS158 YSLSVRDYDP 168 RQGDTVKHYK178 IRTLDNGGFY188 ISPRSTFSTL198 QELVDHYKKG208 NDGLCQKLSV 218 PCMSSKPQKP228 WEKDAWEIPR238 ESLKLEKKLG248 AGQFGEVWMA258 TYNKHTKVAV 268 KTMKPGSMSV278 EAFLAEANVM288 KTLQHDKLVK298 LHAVVTKEPI308 YIITEFMAKG 318 SLLDFLKSDE328 GSKQPLPKLI338 DFSAQIAEGM348 AFIEQRNYIH358 RDLRAANILV 368 SASLVCKIAD378 FGLARVIPIK401 WTAPEAINFG411 SFTIKSDVWS421 FGILLMEIVT 431 YGRIPYPGMS441 NPEVIRALER451 GYRMPRPENC461 PEELYNIMMR471 CWKNRPEERP 481 TFEYIQSVLD491 DFYTATESQE502 EIP
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .PTR or .PTR2 or .PTR3 or :3PTR;style chemicals stick;color identity;select .A:130 or .A:150 or .A:151 or .A:152 or .A:153 or .A:154 or .A:155 or .A:160 or .A:176 or .A:177 or .A:178 or .A:497 or .A:498 or .A:499 or .A:500 or .A:502 or .A:503; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| PDB ID: 3VS5 Crystal structure of HCK complexed with a pyrrolo-pyrimidine inhibitor 7-(1-methylpiperidin-4-yl)-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine | ||||||
| Method | X-ray diffraction | Resolution | 2.85 Å | Mutation | Yes | [4] |
| PDB Sequence |
RIIVVALYDY
94 EAIHHEDLSF104 QKGDQMVVLE114 ESGEWWKARS124 LATRKEGYIP134 SNYVARVDSL 144 ETEEWFFKGI154 SRKDAERQLL164 APGNMLGSFM174 IRDSETTKGS184 YSLSVRDYDP 194 RQGDTVKHYK204 IRTGFYISPR218 STFSTLQELV228 DHYKKGNDGL238 CQKLSVPCMS 248 SKPQKPWEKD258 AWEIPRESLK268 LEKKLGAGQF278 GEVWMATYNK288 HTKVAVKTMK 298 PGSMSVEAFL308 AEANVMKTLQ318 HDKLVKLHAV328 VTKEPIYIIT338 EFMAKGSLLD 348 FLKSDEGSKQ358 PLPKLIDFSA368 QIAEGMAFIE378 QRNYIHRDLR388 AANILVSASL 398 VCKIADFGLA408 RVIPIKWTAP431 EAINFGSFTI441 KSDVWSFGIL451 LMEIVTYGRI 461 PYPGMSNPEV471 IRALERGYRM481 PRPENCPEEL491 YNIMMRCWKN501 RPEERPTFEY 511 IQSVLDDFYT521 ATESQEEIP
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .PTR or .PTR2 or .PTR3 or :3PTR;style chemicals stick;color identity;select .A:156 or .A:176 or .A:177 or .A:178 or .A:179 or .A:180 or .A:181 or .A:186 or .A:202 or .A:203 or .A:204 or .A:524 or .A:525 or .A:526 or .A:528 or .A:529; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| PDB ID: 4LUD Crystal Structure of HCK in complex with the fluorescent compound SKF86002 | ||||||
| Method | X-ray diffraction | Resolution | 2.85 Å | Mutation | Yes | [5] |
| PDB Sequence |
RIIVVALYDY
94 EAIHHEDLSF104 QKGDQMVVLE114 ESGEWWKARS124 LATRKEGYIP134 SNYVARLETE 147 EWFFKGISRK157 DAERQLLAPG167 NMLGSFMIRD177 SETTKGSYSL187 SVRDYDPRQG 197 DTVKHYKIRT207 LDGFYISPRS219 TFSTLQELVD229 HYKKGNDGLC239 QKLSVPCMSS 249 KPQKPWEKDA259 WEIPRESLKL269 EKKLGAGQFG279 EVWMATYNKH289 TKVAVKTMKP 299 SVEAFLAEAN312 VMKTLQHDKL322 VKLHAVVTKE332 PIYIITEFMA342 KGSLLDFLKS 352 DEGSKQPLPK362 LIDFSAQIAE372 GMAFIEQRNY382 IHRDLRAANI392 LVSASLVCKI 402 ADFGLARVIP425 IKWTAPEAIN435 FGSFTIKSDV445 WSFGILLMEI455 VTYGRIPYPG 465 MSNPELERGY479 RMPRPENCPE489 ELYNIMMRCW499 KNRPEERPTF509 EYIQSVLDDF 519 YTATESQEEI530 P
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .PTR or .PTR2 or .PTR3 or :3PTR;style chemicals stick;color identity;select .A:156 or .A:176 or .A:177 or .A:178 or .A:179 or .A:180 or .A:181 or .A:186 or .A:202 or .A:203 or .A:204 or .A:524 or .A:525 or .A:526 or .A:528 or .A:529; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| PDB ID: 3VS0 Crystal structure of HCK complexed with a pyrrolo-pyrimidine inhibitor N-[4-(4-amino-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)phenyl]benzamide | ||||||
| Method | X-ray diffraction | Resolution | 2.93 Å | Mutation | Yes | [4] |
| PDB Sequence |
RIIVVALYDY
94 EAIHHEDLSF104 QKGDQMVVLE114 ESGEWWKARS124 LATRKEGYIP134 SNYVARVDSL 144 ETEEWFFKGI154 SRKDAERQLL164 APGNMLGSFM174 IRDSETTKGS184 YSLSVRDYDP 194 RQGDTVKHYK204 IRGFYISPRS219 TFSTLQELVD229 HYKKGNDGLC239 QKLSVPCMSS 249 KPQKPWEKDA259 WEIPRESLKL269 EKKLGAGQFG279 EVWMATYNKH289 TKVAVKTMKP 299 GSMSVEAFLA309 EANVMKTLQH319 DKLVKLHAVV329 TKEPIYIITE339 FMAKGSLLDF 349 LKSDEGSKQP359 LPKLIDFSAQ369 IAEGMAFIEQ379 RNYIHRDLRA389 ANILVSASLV 399 CKIADFGLAR409 VIPIKWTAPE432 AINFGSFTIK442 SDVWSFGILL452 MEIVTYGRIP 462 YPGMSNPEVI472 RALERGYRMP482 RPENCPEELY492 NIMMRCWKNR502 PEERPTFEYI 512 QSVLDDFYTA522 TESQEEIP
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .PTR or .PTR2 or .PTR3 or :3PTR;style chemicals stick;color identity;select .A:156 or .A:176 or .A:177 or .A:178 or .A:179 or .A:180 or .A:181 or .A:186 or .A:202 or .A:203 or .A:204 or .A:524 or .A:525 or .A:526 or .A:528 or .A:529; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| PDB ID: 3VS7 Crystal structure of HCK complexed with a pyrazolo-pyrimidine inhibitor 1-cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine | ||||||
| Method | X-ray diffraction | Resolution | 3.00 Å | Mutation | Yes | [4] |
| PDB Sequence |
RIIVVALYDY
94 EAIHHEDLSF104 QKGDQMVVLE114 ESGEWWKARS124 LATRKEGYIP134 SNYVARVDSL 144 ETEEWFFKGI154 SRKDAERQLL164 APGNMLGSFM174 IRDSETTKGS184 YSLSVRDYDP 194 RQGDTVKHYK204 IRTLDNGGFY214 ISPRSTFSTL224 QELVDHYKKG234 NDGLCQKLSV 244 PCMSSKPQKP254 WEKDAWEIPR264 ESLKLEKKLG274 AGQFGEVWMA284 TYNKHTKVAV 294 KTMKPGSMSV304 EAFLAEANVM314 KTLQHDKLVK324 LHAVVTKEPI334 YIITEFMAKG 344 SLLDFLKSDE354 GSKQPLPKLI364 DFSAQIAEGM374 AFIEQRNYIH384 RDLRAANILV 394 SASLVCKIAD404 FGLARVPIKW428 TAPEAINFGS438 FTIKSDVWSF448 GILLMEIVTY 458 GRIPYPGMSN468 PEVIRALERG478 YRMPRPENCP488 EELYNIMMRC498 WKNRPEERPT 508 FEYIQSVLDD518 FYTATESQEE529 IP
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .PTR or .PTR2 or .PTR3 or :3PTR;style chemicals stick;color identity;select .A:156 or .A:176 or .A:177 or .A:178 or .A:179 or .A:180 or .A:181 or .A:186 or .A:202 or .A:203 or .A:204 or .A:524 or .A:525 or .A:526 or .A:528 or .A:529; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| PDB ID: 4LUE Crystal Structure of HCK in complex with 7-[trans-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (resulting from displacement of SKF86002) | ||||||
| Method | X-ray diffraction | Resolution | 3.04 Å | Mutation | Yes | [5] |
| PDB Sequence |
RIIVVALYDY
94 EAIHHEDLSF104 QKGDQMVVLE114 ESGEWWKARS124 LATRKEGYIP134 SNYVARVDSL 144 ETEEWFFKGI154 SRKDAERQLL164 APGNMLGSFM174 IRDSETTKGS184 YSLSVRDYDP 194 RQGDTVKHYK204 IRTGFYISPR218 STFSTLQELV228 DHYKKGNDGL238 CQKLSVPCMS 248 SKPQKPWEKD258 AWEIPRESLK268 LEKKLGAGQF278 GEVWMATYNK288 HTKVAVKTMK 298 PGSLAEANVM314 KTLQHDKLVK324 LHAVVTKEPI334 YIITEFMAKG344 SLLDFLKSDE 354 GSKQPLPKLI364 DFSAQIAEGM374 AFIEQRNYIH384 RDLRAANILV394 SASLVCKIAD 404 FGLARVIPIK427 WTAPEAINFG437 SFTIKSDVWS447 FGILLMEIVT457 YGRIPYPGMS 467 NPEVIRALER477 GYRMPRPENC487 PEELYNIMMR497 CWKNRPEERP507 TFEYIQSVLD 517 DFYTATESQE528 EI
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .PTR or .PTR2 or .PTR3 or :3PTR;style chemicals stick;color identity;select .A:156 or .A:176 or .A:177 or .A:178 or .A:179 or .A:180 or .A:181 or .A:186 or .A:202 or .A:203 or .A:204 or .A:524 or .A:525 or .A:526 or .A:528 or .A:529; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| PDB ID: 1AD5 SRC FAMILY KINASE HCK-AMP-PNP COMPLEX | ||||||
| Method | X-ray diffraction | Resolution | 2.60 Å | Mutation | Yes | [6] |
| PDB Sequence |
EDIIVVALYD
91 YEAIHHEDLS101 FQKGDQMVVL111 EESGEWWKAR122 SLATRKEGYI132 PSNYVARVDS 142 LETEEWFFKG152 ISRKDAERQL162 LAPGNMLGSF172 MIRDSETTKG182 SYSLSVRDYD 192 PRQGDTVKHY202 KIRTLDNGGF212 YISPRSTFST222 LQELVDHYKK232 GNDGLCQKLS 242 VPCMSSKPQK252 PWEKDAWEIP263 RESLKLEKKL273 GAGQFGEVWM283 ATYNKHTKVA 293 VKTMKPGSMS303 VEAFLAEANV313 MKTLQHDKLV323 KLHAVVTKEP333 IYIITEFMAK 343 GSLLDFLKSD353 EGSKQPLPKL363 IDFSAQIAEG373 MAFIEQRNYI383 HRDLRAANIL 393 VSASLVCKIA403 DFGLARVGAK423 FPIKWTAPEA433 INFGSFTIKS443 DVWSFGILLM 453 EIVTYGRIPY463 PGMSNPEVIR473 ALERGYRMPR483 PENCPEELYN493 IMMRCWKNRP 503 EERPTFEYIQ513 SVLDDFYTAT523 ESQQQQP
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .PTR or .PTR2 or .PTR3 or :3PTR;style chemicals stick;color identity;select .A:155 or .A:175 or .A:176 or .A:177 or .A:178 or .A:179 or .A:180 or .A:184 or .A:185 or .A:201 or .A:202 or .A:203 or .A:523 or .A:524 or .A:525 or .A:526 or .A:528 or .A:529; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| PDB ID: 2HCK SRC FAMILY KINASE HCK-QUERCETIN COMPLEX | ||||||
| Method | X-ray diffraction | Resolution | 3.00 Å | Mutation | Yes | [6] |
| PDB Sequence |
EDIIVVALYD
91 YEAIHHEDLS101 FQKGDQMVVL111 EESGEWWKAR122 SLATRKEGYI132 PSNYVARVDS 142 LETEEWFFKG152 ISRKDAERQL162 LAPGNMLGSF172 MIRDSETTKG182 SYSLSVRDYD 192 PRQGDTVKHY202 KIRTLDNGGF212 YISPRSTFST222 LQELVDHYKK232 GNDGLCQKLS 242 VPCMSSKPQK252 PWEKDAWEIP263 RESLKLEKKL273 GAGQFGEVWM283 ATYNKHTKVA 293 VKTMKPGSMS303 VEAFLAEANV313 MKTLQHDKLV323 KLHAVVTKEP333 IYIITEFMAK 343 GSLLDFLKSD353 EGSKQPLPKL363 IDFSAQIAEG373 MAFIEQRNYI383 HRDLRAANIL 393 VSASLVCKIA403 DFGLARVGAK423 FPIKWTAPEA433 INFGSFTIKS443 DVWSFGILLM 453 EIVTYGRIPY463 PGMSNPEVIR473 ALERGYRMPR483 PENCPEELYN493 IMMRCWKNRP 503 EERPTFEYIQ513 SVLDDFYTAT523 ESQQQQP
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .PTR or .PTR2 or .PTR3 or :3PTR;style chemicals stick;color identity;select .A:155 or .A:175 or .A:176 or .A:177 or .A:178 or .A:179 or .A:180 or .A:185 or .A:186 or .A:201 or .A:202 or .A:203 or .A:523 or .A:524 or .A:525 or .A:526 or .A:528 or .A:529; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Activity cliff for 7-substituted pyrrolo-pyrimidine inhibitors of HCK explained in terms of predicted basicity of the amine nitrogen. Bioorg Med Chem. 2017 Aug 15;25(16):4259-4264. | ||||
| REF 2 | Crystal structure of Hck in complex with a Src family-selective tyrosine kinase inhibitor. Mol Cell. 1999 May;3(5):639-48. | ||||
| REF 3 | Discovery of A-770041, a src-family selective orally active lck inhibitor that prevents organ allograft rejection. Bioorg Med Chem Lett. 2006 Jan 1;16(1):118-22. | ||||
| REF 4 | A pyrrolo-pyrimidine derivative targets human primary AML stem cells in vivo. Sci Transl Med. 2013 Apr 17;5(181):181ra52. | ||||
| REF 5 | Kinase crystal identification and ATP-competitive inhibitor screening using the fluorescent ligand SKF86002. Acta Crystallogr D Biol Crystallogr. 2014 Feb;70(Pt 2):392-404. | ||||
| REF 6 | Crystal structure of the Src family tyrosine kinase Hck. Nature. 1997 Feb 13;385(6617):602-9. | ||||
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