Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T15377 | Target Info | |||
| Target Name | Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2) | ||||
| Synonyms | SR Ca(2+)Sarcoplasmic/endoplasmic reticulum calcium ATPase 2-ATPase 2; SR Ca(2+)-ATPase 2; SR Ca(2+)-ATPase; SR Ca(2+) pump; SERCA2; Endoplasmic reticulum class 1/2 Ca(2+) ATPase; Cardiacsarcoplasmic reticulum calcium ATPase; CardiacCa2+ ATPase (SERCA2a); Calciumpump 2; Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform; Calcium pump 2; ATP2B | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | ATP2A2 | ||||
| Biochemical Class | Cation transporting ATPase | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | L-betagamma-meATP | Ligand Info | |||
| Canonical SMILES | C1=NC(=C2C(=N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)OP(=O)(CP(=O)(O)O)O)O)O)N | ||||
| InChI | 1S/C11H18N5O12P3/c12-9-6-10(14-2-13-9)16(3-15-6)11-8(18)7(17)5(27-11)1-26-31(24,25)28-30(22,23)4-29(19,20)21/h2-3,5,7-8,11,17-18H,1,4H2,(H,22,23)(H,24,25)(H2,12,13,14)(H2,19,20,21)/t5-,7-,8-,11-/m1/s1 | ||||
| InChIKey | UFZTZBNSLXELAL-IOSLPCCCSA-N | ||||
| PubChem Compound ID | 91532 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 6LN5 CryoEM structure of SERCA2b T1032stop in E1-2Ca2+-AMPPCP (class1) | ||||||
| Method | Electron microscopy | Resolution | 2.80 Å | Mutation | No | [1] |
| PDB Sequence |
MENAHTKTVE
10 EVLGHFGVNE20 STGLSLEQVK30 KLKERWGSNE40 LPAEEGKTLL50 ELVIEQFEDL 60 LVRILLLAAC70 ISFVLAWFEE80 GEETITAFVE90 PFVILLILVA100 NAIVGVWQER 110 NAENAIEALK120 EYEPEMGKVY130 RQDRKSVQRI140 KAKDIVPGDI150 VEIAVGDKVP 160 ADIRLTSIKS170 TTLRVDQSIL180 TGESVSVIKH190 TDPVPDPRAV200 NQDKKNMLFS 210 GTNIAAGKAM220 GVVVATGVNT230 EIGKIRDEMV240 ATEQERTPLQ250 QKLDEFGEQL 260 SKVISLICIA270 VWIINIGHFN280 DPVHGGSWIR290 GAIYYFKIAV300 ALAVAAIPEG 310 LPAVITTCLA320 LGTRRMAKKN330 AIVRSLPSVE340 TLGCTSVICS350 DKTGTLTTNQ 360 MSVCRMFILD370 RVEGDTCSLN380 EFTITGSTYA390 PIGEVHKDDK400 PVNCHQYDGL 410 VELATICALC420 NDSALDYNEA430 KGVYEKVGEA440 TETALTCLVE450 KMNVFDTELK 460 GLSKIERANA470 CNSVIKQLMK480 KEFTLEFSRD490 RKSMSVYCTP500 NKPSRTSMSK 510 MFVKGAPEGV520 IDRCTHIRVG530 STKVPMTSGV540 KQKIMSVIRE550 WGSGSDTLRC 560 LALATHDNPL570 RREEMHLEDS580 ANFIKYETNL590 TFVGCVGMLD600 PPRIEVASSV 610 KLCRQAGIRV620 IMITGDNKGT630 AVAICRRIGI640 FGQDEDVTSK650 AFTGREFDEL 660 NPSAQRDACL670 NARCFARVEP680 SHKSKIVEFL690 QSFDEITAMT700 GDGVNDAPAL 710 KKAEIGIAMG720 SGTAVAKTAS730 EMVLADDNFS740 TIVAAVEEGR750 AIYNNMKQFI 760 RYLISSNVGE770 VVCIFLTAAL780 GFPEALIPVQ790 LLWVNLVTDG800 LPATALGFNP 810 PDLDIMNKPP820 RNPKEPLISG830 WLFFRYLAIG840 CYVGAATVGA850 AAWWFIAADG 860 GPRVSFYQLS870 HFLQCKEDNP880 DFEGVDCAIF890 ESPYPMTMAL900 SVLVTIEMCN 910 ALNSLSENQS920 LLRMPPWENI930 WLVGSICLSM940 SLHFLILYVE950 PLPLIFQITP 960 LNVTQWLMVL970 KISLPVILMD980 ETLKFVARNY990 LEGISWPFVL1020 LIMPLVIWVY 1030 S
|
|||||
|
|
ASP351
2.617
LYS352
3.423
THR353
3.081
THR441
4.436
GLU442
3.139
PHE487
3.244
ARG489
2.865
LYS492
3.730
SER493
4.190
MET494
3.865
LYS514
3.399
GLY515
3.479
ALA516
3.730
PRO517
4.740
|
|||||
| PDB ID: 6LN7 CryoEM structure of SERCA2b T1032stop in E1-2Ca2+-AMPPCP (class3) | ||||||
| Method | Electron microscopy | Resolution | 2.80 Å | Mutation | No | [1] |
| PDB Sequence |
MENAHTKTVE
10 EVLGHFGVNE20 STGLSLEQVK30 KLKERWGSNE40 LPAEEGKTLL50 ELVIEQFEDL 60 LVRILLLAAC70 ISFVLAWFEE80 GEETITAFVE90 PFVILLILVA100 NAIVGVWQER 110 NAENAIEALK120 EYEPEMGKVY130 RQDRKSVQRI140 KAKDIVPGDI150 VEIAVGDKVP 160 ADIRLTSIKS170 TTLRVDQSIL180 TGESVSVIKH190 TDPVPDPRAV200 NQDKKNMLFS 210 GTNIAAGKAM220 GVVVATGVNT230 EIGKIRDEMV240 ATEQERTPLQ250 QKLDEFGEQL 260 SKVISLICIA270 VWIINIGHFN280 DPVHGGSWIR290 GAIYYFKIAV300 ALAVAAIPEG 310 LPAVITTCLA320 LGTRRMAKKN330 AIVRSLPSVE340 TLGCTSVICS350 DKTGTLTTNQ 360 MSVCRMFILD370 RVEGDTCSLN380 EFTITGSTYA390 PIGEVHKDDK400 PVNCHQYDGL 410 VELATICALC420 NDSALDYNEA430 KGVYEKVGEA440 TETALTCLVE450 KMNVFDTELK 460 GLSKIERANA470 CNSVIKQLMK480 KEFTLEFSRD490 RKSMSVYCTP500 NKPSRTSMSK 510 MFVKGAPEGV520 IDRCTHIRVG530 STKVPMTSGV540 KQKIMSVIRE550 WGSGSDTLRC 560 LALATHDNPL570 RREEMHLEDS580 ANFIKYETNL590 TFVGCVGMLD600 PPRIEVASSV 610 KLCRQAGIRV620 IMITGDNKGT630 AVAICRRIGI640 FGQDEDVTSK650 AFTGREFDEL 660 NPSAQRDACL670 NARCFARVEP680 SHKSKIVEFL690 QSFDEITAMT700 GDGVNDAPAL 710 KKAEIGIAMG720 SGTAVAKTAS730 EMVLADDNFS740 TIVAAVEEGR750 AIYNNMKQFI 760 RYLISSNVGE770 VVCIFLTAAL780 GFPEALIPVQ790 LLWVNLVTDG800 LPATALGFNP 810 PDLDIMNKPP820 RNPKEPLISG830 WLFFRYLAIG840 CYVGAATVGA850 AAWWFIAADG 860 GPRVSFYQLS870 HFLQCKEDNP880 DFEGVDCAIF890 ESPYPMTMAL900 SVLVTIEMCN 910 ALNSLSENQS920 LLRMPPWENI930 WLVGSICLSM940 SLHFLILYVE950 PLPLIFQITP 960 LNVTQWLMVL970 KISLPVILMD980 ETLKFVARNY990 LEGISWPFVL1020 LIMPLVIWVY 1030 S
|
|||||
|
|
ASP351
2.752
LYS352
3.167
THR353
2.999
THR441
4.635
GLU442
2.613
PHE487
3.441
ARG489
3.037
LYS492
4.001
SER493
4.195
MET494
3.902
LYS514
3.296
GLY515
3.416
ALA516
3.884
PRO517
4.697
|
|||||
| PDB ID: 6LN6 CryoEM structure of SERCA2b T1032stop in E1-2Ca2+-AMPPCP (class2) | ||||||
| Method | Electron microscopy | Resolution | 2.90 Å | Mutation | No | [1] |
| PDB Sequence |
MENAHTKTVE
10 EVLGHFGVNE20 STGLSLEQVK30 KLKERWGSNE40 LPAEEGKTLL50 ELVIEQFEDL 60 LVRILLLAAC70 ISFVLAWFEE80 GEETITAFVE90 PFVILLILVA100 NAIVGVWQER 110 NAENAIEALK120 EYEPEMGKVY130 RQDRKSVQRI140 KAKDIVPGDI150 VEIAVGDKVP 160 ADIRLTSIKS170 TTLRVDQSIL180 TGESVSVIKH190 TDPVPDPRAV200 NQDKKNMLFS 210 GTNIAAGKAM220 GVVVATGVNT230 EIGKIRDEMV240 ATEQERTPLQ250 QKLDEFGEQL 260 SKVISLICIA270 VWIINIGHFN280 DPVHGGSWIR290 GAIYYFKIAV300 ALAVAAIPEG 310 LPAVITTCLA320 LGTRRMAKKN330 AIVRSLPSVE340 TLGCTSVICS350 DKTGTLTTNQ 360 MSVCRMFILD370 RVEGDTCSLN380 EFTITGSTYA390 PIGEVHKDDK400 PVNCHQYDGL 410 VELATICALC420 NDSALDYNEA430 KGVYEKVGEA440 TETALTCLVE450 KMNVFDTELK 460 GLSKIERANA470 CNSVIKQLMK480 KEFTLEFSRD490 RKSMSVYCTP500 NKPSRTSMSK 510 MFVKGAPEGV520 IDRCTHIRVG530 STKVPMTSGV540 KQKIMSVIRE550 WGSGSDTLRC 560 LALATHDNPL570 RREEMHLEDS580 ANFIKYETNL590 TFVGCVGMLD600 PPRIEVASSV 610 KLCRQAGIRV620 IMITGDNKGT630 AVAICRRIGI640 FGQDEDVTSK650 AFTGREFDEL 660 NPSAQRDACL670 NARCFARVEP680 SHKSKIVEFL690 QSFDEITAMT700 GDGVNDAPAL 710 KKAEIGIAMG720 SGTAVAKTAS730 EMVLADDNFS740 TIVAAVEEGR750 AIYNNMKQFI 760 RYLISSNVGE770 VVCIFLTAAL780 GFPEALIPVQ790 LLWVNLVTDG800 LPATALGFNP 810 PDLDIMNKPP820 RNPKEPLISG830 WLFFRYLAIG840 CYVGAATVGA850 AAWWFIAADG 860 GPRVSFYQLS870 HFLQCKEDNP880 DFEGVDCAIF890 ESPYPMTMAL900 SVLVTIEMCN 910 ALNSLSENQS920 LLRMPPWENI930 WLVGSICLSM940 SLHFLILYVE950 PLPLIFQITP 960 LNVTQWLMVL970 KISLPVILMD980 ETLKFVARNY990 LEISWPFVLL1021 IMPLVIWVYS 1031
|
|||||
|
|
ASP351
2.373
LYS352
3.160
THR353
3.043
THR441
4.378
GLU442
3.050
PHE487
3.368
ARG489
3.093
LYS492
3.482
SER493
4.141
MET494
3.846
LYS514
3.038
GLY515
3.365
ALA516
3.923
PRO517
4.751
|
|||||
| PDB ID: 6JJU Structure of Ca2+ ATPase | ||||||
| Method | X-ray diffraction | Resolution | 3.20 Å | Mutation | No | [2] |
| PDB Sequence |
MENAHTKTVE
10 EVLGHFGVNE20 STGLSLEQVK30 KLKERWGSNE40 LPAEEGKTLL50 ELVIEQFEDL 60 LVRILLLAAC70 ISFVLAWFEE80 TAFVEPFVIL95 LILVANAIVG105 VWQERNAENA 115 IEALKEYEPE125 MGKVYRQDRK135 SVQRIKAKDI145 VPGDIVEIAV155 GDKVPADIRL 165 TSIKSTTLRV175 DQSILTGESV185 SVIKHTDPVP195 DPRAVNQDKK205 NMLFSGTNIA 215 AGKAMGVVVA225 TGVNTEIGKI235 RDEMRTPLQQ251 KLDEFGEQLS261 KVISLICIAV 271 WIINIGHDPV283 HGGSWIRGAI293 YYFKIAVALA303 VAAIPEGLPA313 VITTCLALGT 323 RRMAKKNAIV333 RSLPSVETLG343 CTSVICSDKT353 GTLTTNQMSV363 CRMFILDRVE 373 GDTCSLNEFT383 ITGSTYAPIG393 EVHKDDKPVN403 CHQYDGLVEL413 ATICALCNDS 423 ALDYNEAKGV433 YEKVGEATET443 ALTCLVEKMN453 VFDTELKGLS463 KIERANACNS 473 VIKQLMKKEF483 TLEFSRDRKS493 MSVYCTPNKP503 SRTSMSKMFV513 KGAPEGVIDR 523 CTHIRVGSTK533 VPMTSGVKQK543 IMSVIREWGS553 GSDTLRCLAL563 ATHDNPLRRE 573 EMHLEDSANF583 IKYETNLTFV593 GCVGMLDPPR603 IEVASSVKLC613 RQAGIRVIMI 623 TGDNKGTAVA633 ICRRIGIFGQ643 DEDVTSKAFT653 GREFDELNPS663 AQRDACLNAR 673 CFARVEPSHK683 SKIVEFLQSF693 DEITAMTGDG703 VNDAPALKKA713 EIGIAMGSGT 723 AVAKTASEMV733 LADDNFSTIV743 AAVEEGRAIY753 NNMKQFIRYL763 ISSNVGEVVC 773 IFLTAALGFP783 EALIPVQLLW793 VNLVTDGLPA803 TALGFNPPDL813 DIMNKPPRNP 823 KEPLISGWLF833 FRYLAIGCYV843 GAATVGAAAW853 WFIAADGGPR863 VSFYQLSHFL 873 QCNPDFEGVD886 CAIFESPYPM896 TMALSVLVTI906 EMCNALNSLS916 ENQSLLRMPP 926 WENIWLVGSI936 CLSMSLHFLI946 LYVEPLPLIF956 QITPLNVTQW966 LMVLKISLPV 976 ILMDETLKFV986 ARNY
|
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|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .ACP or .ACP2 or .ACP3 or :3ACP;style chemicals stick;color identity;select .A:351 or .A:352 or .A:353 or .A:441 or .A:442 or .A:487 or .A:489 or .A:492 or .A:493 or .A:494 or .A:514 or .A:515 or .A:516 or .A:559 or .A:560 or .A:561 or .A:624 or .A:625 or .A:626 or .A:627 or .A:677 or .A:678 or .A:683 or .A:702 or .A:705 or .A:706; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
ASP351
2.557
LYS352
3.736
THR353
2.845
THR441
4.882
GLU442
3.095
PHE487
3.266
ARG489
3.085
LYS492
3.667
SER493
3.975
MET494
3.584
LYS514
3.278
GLY515
3.425
ALA516
3.562
|
|||||
| PDB ID: 6LLE CryoEM structure of SERCA2b WT in E1-2Ca2+-AMPPCP state. | ||||||
| Method | Electron microscopy | Resolution | 2.90 Å | Mutation | No | [1] |
| PDB Sequence |
MENAHTKTVE
10 EVLGHFGVNE20 STGLSLEQVK30 KLKERWGSNE40 LPAEEGKTLL50 ELVIEQFEDL 60 LVRILLLAAC70 ISFVLAWFEE80 GEETITAFVE90 PFVILLILVA100 NAIVGVWQER 110 NAENAIEALK120 EYEPEMGKVY130 RQDRKSVQRI140 KAKDIVPGDI150 VEIAVGDKVP 160 ADIRLTSIKS170 TTLRVDQSIL180 TGESVSVIKH190 TDPVPDPRAV200 NQDKKNMLFS 210 GTNIAAGKAM220 GVVVATGVNT230 EIGKIRDEMV240 ATEQERTPLQ250 QKLDEFGEQL 260 SKVISLICIA270 VWIINIGHFN280 DPVHGGSWIR290 GAIYYFKIAV300 ALAVAAIPEG 310 LPAVITTCLA320 LGTRRMAKKN330 AIVRSLPSVE340 TLGCTSVICS350 DKTGTLTTNQ 360 MSVCRMFILD370 RVEGDTCSLN380 EFTITGSTYA390 PIGEVHKDDK400 PVNCHQYDGL 410 VELATICALC420 NDSALDYNEA430 KGVYEKVGEA440 TETALTCLVE450 KMNVFDTELK 460 GLSKIERANA470 CNSVIKQLMK480 KEFTLEFSRD490 RKSMSVYCTP500 NKPSSMSKMF 512 VKGAPEGVID522 RCTHIRVGST532 KVPMTSGVKQ542 KIMSVIREWG552 SGSDTLRCLA 562 LATHDNPLRR572 EEMHLEDSAN582 FIKYETNLTF592 VGCVGMLDPP602 RIEVASSVKL 612 CRQAGIRVIM622 ITGDNKGTAV632 AICRRIGIFG642 QDEDVTSKAF652 TGREFDELNP 662 SAQRDACLNA672 RCFARVEPSH682 KSKIVEFLQS692 FDEITAMTGD702 GVNDAPALKK 712 AEIGIAMGSG722 TAVAKTASEM732 VLADDNFSTI742 VAAVEEGRAI752 YNNMKQFIRY 762 LISSNVGEVV772 CIFLTAALGF782 PEALIPVQLL792 WVNLVTDGLP802 ATALGFNPPD 812 LDIMNKPPRN822 PKEPLISGWL832 FFRYLAIGCY842 VGAATVGAAA852 WWFIAADGGP 862 RVSFYQLSHF872 LQCKEDNPDF882 EGVDCAIFES892 PYPMTMALSV902 LVTIEMCNAL 912 NSLSENQSLL922 RMPPWENIWL932 VGSICLSMSL942 HFLILYVEPL952 PLIFQITPLN 962 VTQWLMVLKI972 SLPVILMDET982 LKFVARNYLE992 GISWPFVLLI1022 MPLVIWVYST 1032 DTNFSDMFWS1042
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .ACP or .ACP2 or .ACP3 or :3ACP;style chemicals stick;color identity;select .A:351 or .A:352 or .A:353 or .A:439 or .A:441 or .A:442 or .A:487 or .A:489 or .A:492 or .A:493 or .A:494 or .A:514 or .A:515 or .A:516 or .A:517 or .A:559 or .A:560 or .A:561 or .A:623 or .A:624 or .A:625 or .A:626 or .A:627 or .A:677 or .A:678 or .A:683 or .A:702 or .A:705 or .A:706; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
ASP351
2.420
LYS352
3.249
THR353
2.971
GLU439
2.836
THR441
4.731
GLU442
3.231
PHE487
3.323
ARG489
3.086
LYS492
3.950
SER493
4.329
MET494
3.785
LYS514
3.235
GLY515
3.452
ALA516
3.935
PRO517
4.704
|
|||||
| PDB ID: 5ZTF Structure of Ca2+ ATPase | ||||||
| Method | X-ray diffraction | Resolution | 3.45 Å | Mutation | No | [2] |
| PDB Sequence |
MENAHTKTVE
10 EVLGHFGVNE20 STGLSLEQVK30 KLKERWGSNE40 LPATLLELVI54 EQFEDLLVRI 64 LLLAACISFV74 LAWFTAFVEP91 FVILLILVAN101 AIVGVWQERN111 AENAIEALKE 121 YEPEMGKVYR131 QDRKSVQRIK141 AKDIVPGDIV151 EIAVGDKVPA161 DIRLTSIKST 171 TLRVDQSILT181 GESVSVIKHT191 DPVPDPRAVN201 QDKKNMLFSG211 TNIAAGKAMG 221 VVVATGVNTE231 IGKIRDEMRT247 PLQQKLDEFG257 EQLSKVISLI267 CIAVWIINIG 277 SWIRGAIYYF296 KIAVALAVAA306 IPEGLPAVIT316 TCLALGTRRM326 AKKNAIVRSL 336 PSVETLGCTS346 VICSDKTGTL356 TTNQMSVCRM366 FILDRVEGDT376 CSLNEFTITG 386 STYAPIGEVH396 KDDKPVNCHQ406 YDGLVELATI416 CALCNDSALD426 YNEAKGVYEK 436 VGEATETALT446 CLVEKMNVFD456 TELKGLSKIE466 RANACNSVIK476 QLMKKEFTLE 486 FSRDRKSMSV496 YCTPNKPSSM508 SKMFVKGAPE518 GVIDRCTHIR528 VGSTKVPMTS 538 GVKQKIMSVI548 REWGSGSDTL558 RCLALATHDN568 PLRREEMHLE578 DSANFIKYET 588 NLTFVGCVGM598 LDPPRIEVAS608 SVKLCRQAGI618 RVIMITGDNK628 GTAVAICRRI 638 GIFGQDEDVT648 SKAFTGREFD658 ELNPSAQRDA668 CLNARCFARV678 EPSHKSKIVE 688 FLQSFDEITA698 MTGDGVNDAP708 ALKKAEIGIA718 MGSGTAVAKT728 ASEMVLADDN 738 FSTIVAAVEE748 GRAIYNNMKQ758 FIRYLISSNV768 GEVVCIFLTA778 ALGFPEALIP 788 VQLLWVNLVT798 DGLPATALGF808 NPPDLDIMNK818 PPRNPKEPLI828 SGWLFFRYLA 838 IGCYVGAATV848 GAAAWWFIAA858 DGGPRVSFYQ868 LSHFLKEDNP880 DFEGVDCAIF 890 ESPYPMTMAL900 SVLVTIEMCN910 ALNSLSENQS920 LLRMPPWENI930 WLVGSICLSM 940 SLHFLILYVE950 PLPLIFQIPL961 NVTQWLMVLK971 ISLPVILMDE981 TLKFVARNYF 1018 VLLIMPLVIW1028 VY
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .ACP or .ACP2 or .ACP3 or :3ACP;style chemicals stick;color identity;select .A:351 or .A:352 or .A:353 or .A:441 or .A:442 or .A:487 or .A:489 or .A:492 or .A:493 or .A:494 or .A:514 or .A:515 or .A:516 or .A:517 or .A:559 or .A:560 or .A:561 or .A:623 or .A:624 or .A:625 or .A:626 or .A:677 or .A:678 or .A:683 or .A:702 or .A:705; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
ASP351
2.688
LYS352
3.315
THR353
2.634
THR441
4.879
GLU442
2.851
PHE487
3.095
ARG489
2.737
LYS492
4.128
SER493
4.283
MET494
3.744
LYS514
3.039
GLY515
3.748
ALA516
3.503
|
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Cryo-EM structures of SERCA2b reveal the mechanism of regulation by the luminal extension tail. Sci Adv. 2020 Aug 12;6(33):eabb0147. | ||||
| REF 2 | Structural Basis of Sarco/Endoplasmic Reticulum Ca(2+)-ATPase 2b Regulation via Transmembrane Helix Interplay. Cell Rep. 2019 Apr 23;27(4):1221-1230.e3. | ||||
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