Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T99189 | Target Info | |||
| Target Name | Sodium/bile acid cotransporter (SLC10A1) | ||||
| Synonyms | Solute carrier family 10 member 1; Sodium/taurocholate cotransporting polypeptide; Na(+)/taurocholate transport protein; Na(+)/bile acid cotransporter; Cell growth-inhibiting gene 29 protein | ||||
| Target Type | Successful Target | ||||
| Gene Name | SLC10A1 | ||||
| Biochemical Class | Bile acid:sodium symporter (BASS) (TC 2.A.28) family | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Cholesterol | Ligand Info | |||||
| Structure Description | Structure of the human sodium/bile acid cotransporter (NTCP) in complex with Fab and nanobody | PDB:7ZYI | ||||
| Method | Electron microscopy | Resolution | 2.88 Å | Mutation | No | [1] |
| PDB Sequence |
GKRPTDLALS
28 VILVFMLFFI38 MLSLGCTMEF48 SKIKAHLWKP58 KGLAIALVAQ68 YGIMPLTAFV 78 LGKVFRLKNI88 EALAILVCGC98 SPGGNLSNVF108 SLAMKGDMNL118 SIVMTTCSTF 128 CALGMMPLLL138 YIYSRGIYDG148 DLKDKVPYKG158 IVISLVLVLI168 PCTIGIVLKS 178 KRPQYMRYVI188 KGGMIIILLC198 SVAVTVLSAI208 NVGKSIMFAM218 TPLLIATSSL 228 MPFIGFLLGY238 VLSALFCLNG248 RCRRTVSMET258 GCQNVQLCST268 ILNVAFPPEV 278 IGPLFFFPLL288 YMIFQLGEGL298 LLIAIFWCYE308 KFK
|
|||||
|
|
THR203
4.791
SER206
3.446
ALA207
3.708
VAL210
3.547
MET215
3.550
PHE216
3.225
ALA217
3.926
MET218
3.524
PHE231
3.810
LEU235
3.605
TYR238
2.376
|
|||||
| Ligand Name: glycochenodeoxycholic acid | Ligand Info | |||||
| Structure Description | Structure of the human sodium/bile acid cotransporter (NTCP) in complex with Fab and nanobody | PDB:7ZYI | ||||
| Method | Electron microscopy | Resolution | 2.88 Å | Mutation | No | [1] |
| PDB Sequence |
GKRPTDLALS
28 VILVFMLFFI38 MLSLGCTMEF48 SKIKAHLWKP58 KGLAIALVAQ68 YGIMPLTAFV 78 LGKVFRLKNI88 EALAILVCGC98 SPGGNLSNVF108 SLAMKGDMNL118 SIVMTTCSTF 128 CALGMMPLLL138 YIYSRGIYDG148 DLKDKVPYKG158 IVISLVLVLI168 PCTIGIVLKS 178 KRPQYMRYVI188 KGGMIIILLC198 SVAVTVLSAI208 NVGKSIMFAM218 TPLLIATSSL 228 MPFIGFLLGY238 VLSALFCLNG248 RCRRTVSMET258 GCQNVQLCST268 ILNVAFPPEV 278 IGPLFFFPLL288 YMIFQLGEGL298 LLIAIFWCYE308 KFK
|
|||||
|
|
LEU27
4.614
SER28
4.948
LEU31
3.768
VAL32
4.124
MET34
3.964
LEU35
3.543
ILE38
3.532
GLY102
4.529
ASN103
3.692
LEU104
3.688
VAL107
4.545
SER162
4.842
ILE195
4.340
SER199
4.233
|
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structure of human NTCP reveals the basis of recognition and sodium-driven transport of bile salts into the liver. Cell Res. 2022 Aug;32(8):773-776. | ||||
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