Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T97587 | Target Info | |||
| Target Name | Integrin alpha-4 (ITGA4) | ||||
| Synonyms | Very late antigen 4; VLA4 subunit alpha; VLA-4 subunit alpha; VLA-4; Integrin alphaIV; Integrin alpha4; Integrin alpha-IV; CD49d; CD49 antigenlike family member D; CD49 antigen-like family member D | ||||
| Target Type | Successful Target | ||||
| Gene Name | ITGA4 | ||||
| Biochemical Class | Integrin | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: N-(2,6-Dichlorobenzoyl)-4-[1,6-Dimethyl-2-Oxo-4-(Trifluoromethyl)-1,2-Dihydropyridin-3-Yl]-L-Phenylalanine | Ligand Info | |||||
| Structure Description | crystal structure of a4b7 headpiece complexed with Fab ACT-1 and RO0505376 | PDB:3V4V | ||||
| Method | X-ray diffraction | Resolution | 3.10 Å | Mutation | Yes | [1] |
| PDB Sequence |
YNVDTESALL
10 YQGPHNTLFG20 YSVVLHSHGA30 NRWLLVGAPT40 ANWLANASVI50 NPGAIYRCRI 60 GKNPGQTCEQ70 LQLGSPNGEP80 CGKTCLEERD90 NQWLGVTLSR100 QPGENGSIVT 110 CGHRWKNIFY120 IKNENKLPTG130 GCYGVPPDLR140 TELSKRIAPC150 YQDYVKKFGE 160 NFASCQAGIS170 SFYTKDLIVM180 GAPGSSYWTG190 SLFVYNITTN200 KYKAFLDKQN 210 QVKFGSYLGY220 SVGAGHFRSQ230 HTTEVVGGAP240 QHEQIGKAYI250 FSIDEKELNI 260 LHEMKGKKLG270 SYFGASVCAV280 DLNADGFSDL290 LVGAPMQSTI300 REEGRVFVYI 310 NSGSGAVMNA320 METNLVGSDK330 YAARFGESIV340 NLGDIDNDGF350 EDVAIGAPQE 360 DDLQGAIYIY370 NGRADGISST380 FSQRIEGLQI390 SKSLSMFGQS400 ISGQIDADNN 410 GYVDVAVGAF420 RSDSAVLLRT430 RPVVIVDASL440 SHPESVNRTK450 FDCVENGWPS 460 VCIDLTLCFS470 YKGKEVPGYI480 VLFYNMSLDV490 NRKAESPPRF500 YFSSNGTSDV 510 ITGSIQVSSR520 EANCRTHQAF530 MRKDVRDILT540 PIQIEAAYHL550 GPHSTEEFPP 565 LQPILQQKKE575 KDIMKKTINF585 AR
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structural specializations of Alpha(4)beta(7), an integrin that mediates rolling adhesion. J Cell Biol. 2012 Jan 9;196(1):131-46. | ||||
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