Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T94593 Target Info
Target Name Cardiac phospholamban (PLN)
Synonyms Phospholamban; PLN; PLB
Target Type Literature-reported Target
Gene Name PLN
UniProt ID
PPLA_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: AMP-PNP Ligand Info
Structure Description Crystal structure of PKAc-PLN complex PDB:7E0Z
Method X-ray diffraction Resolution 2.16 Å Mutation No [1]
PDB Sequence
TRSAIRRAST
17
IE
Residue
Distance (Å)
ARG13
3.050
ARG14
4.485
Residue
Distance (Å)
ALA15
3.560
SER16
2.564
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Ligand Name: Phosphonothreonine Ligand Info
Structure Description Crystal structure of PKAc-A11E complex PDB:7E12
Method X-ray diffraction Resolution 2.80 Å Mutation No [1]
PDB Sequence
EIRRASTIE
Residue
Distance (Å)
ILE18
4.850
Residue
Distance (Å)
References  Top
REF 1 Structures of PKA-phospholamban complexes reveal a mechanism of familial dilated cardiomyopathy. Elife. 2022 Mar 17;11:e75346.

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