Target Binding Site Detail

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Target General Information
Ligand General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T94593 Target Info
Target Name Cardiac phospholamban (PLN)
Synonyms Phospholamban; PLN; PLB
Target Type Literature-reported Target
Gene Name PLN
UniProt ID
PPLA_HUMAN
Ligand General Information  Top
Ligand Name AMP-PNP Ligand Info
Canonical SMILES C1=NC(=C2C(=N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)OP(=O)(NP(=O)(O)O)O)O)O)N
InChI 1S/C10H17N6O12P3/c11-8-5-9(13-2-12-8)16(3-14-5)10-7(18)6(17)4(27-10)1-26-31(24,25)28-30(22,23)15-29(19,20)21/h2-4,6-7,10,17-18H,1H2,(H,24,25)(H2,11,12,13)(H4,15,19,20,21,22,23)/t4-,6-,7-,10-/m1/s1
InChIKey PVKSNHVPLWYQGJ-KQYNXXCUSA-N
PubChem Compound ID 33113
Drug Binding Sites of Target  Top
PDB ID: 7E0Z      Crystal structure of PKAc-PLN complex
Method X-ray diffraction Resolution 2.16 Å Mutation No [1]
PDB Sequence
TRSAIRRAST
17
IE
Residue
Distance (Å)
ARG13
3.050
ARG14
4.485
Residue
Distance (Å)
ALA15
3.560
SER16
2.564
PDB ID: 7E12      Crystal structure of PKAc-A11E complex
Method X-ray diffraction Resolution 2.80 Å Mutation No [1]
PDB Sequence
EIRRASTIE
Residue
Distance (Å)
ARG13
2.932
ARG14
4.684
Residue
Distance (Å)
ALA15
3.695
SER16
2.746
PDB ID: 7E11      Crystal structure of PKAc-PLN R9C complex
Method X-ray diffraction Resolution 3.43 Å Mutation No [1]
PDB Sequence
TCSAIRRAST
17
IE
Residue
Distance (Å)
ARG13
3.056
ARG14
4.393
Residue
Distance (Å)
ALA15
4.185
SER16
3.240
References  Top
REF 1 Structures of PKA-phospholamban complexes reveal a mechanism of familial dilated cardiomyopathy. Elife. 2022 Mar 17;11:e75346.

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