Binding Site Information of Target

Content Navigation (  All   None )                                      
Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T93995 Target Info
Target Name Ubiquitin-like protein Nedd8 (NEDD8)
Synonyms Neural precursor cell expressed developmentally down-regulated protein 8; Neddylin; NEDD-8
Target Type Clinical trial Target
Gene Name NEDD8
Biochemical Class Ubiquitin family
UniProt ID
NEDD8_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: Adenosine triphosphate Ligand Info
Structure Description Structure of APPBP1-UBA3~NEDD8-NEDD8-MgATP-Ubc12(C111A), a trapped ubiquitin-like protein activation complex PDB:2NVU
Method X-ray diffraction Resolution 2.80 Å Mutation Yes [1]
PDB Sequence
MLIKVKTLTG
10
KEIEIDIEPT
20
DKVERIKERV
30
EEKEGIPPQQ
40
QRLIYSGKQM
50

NDEKTAADYK
60
ILGGSVLHLV
70
LALRGG
Residue
Distance (Å)
GLY75
4.968
Residue
Distance (Å)
GLY76
2.896
Click to View More Binding Site Information of This Target and Ligand Pair
Ligand Name: MLN4924 Ligand Info
Structure Description Structure of NEDD8-activating enzyme in complex with NEDD8 and MLN4924 PDB:3GZN
Method X-ray diffraction Resolution 3.00 Å Mutation No [2]
PDB Sequence
HHHMLIKVKT
7
LTGKEIEIDI
17
EPTDKVERIK
27
ERVEEKEGIP
37
PQQQRLIYSG
47

KQMNDEKTAA
57
DYKILGGSVL
67
HLVLALRGG
Residue
Distance (Å)
GLY75
3.980
Residue
Distance (Å)
GLY76
1.266
References  Top
REF 1 Basis for a ubiquitin-like protein thioester switch toggling E1-E2 affinity. Nature. 2007 Jan 25;445(7126):394-8.
REF 2 Substrate-assisted inhibition of ubiquitin-like protein-activating enzymes: the NEDD8 E1 inhibitor MLN4924 forms a NEDD8-AMP mimetic in situ. Mol Cell. 2010 Jan 15;37(1):102-11.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.