Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T93903 | Target Info | |||
| Target Name | Caspase-9 (CASP9) | ||||
| Synonyms | MCH6; ICE-like apoptotic protease 6; ICE-LAP6; CASP-9; Apoptotic protease-activating factor 3; Apoptotic protease activating factor 3; Apoptotic protease Mch-6; APAF-3 | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | CASP9 | ||||
| Biochemical Class | Peptidase | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: D-malate | Ligand Info | |||||
| Structure Description | Crystal structure of a dimeric caspase-9 | PDB:2AR9 | ||||
| Method | X-ray diffraction | Resolution | 2.80 Å | Mutation | Yes | [1] |
| PDB Sequence |
GALESLRGNA
149 DLAYILSMEP159 CGHCLIINNV169 NFCRESGLRT179 RTGSNIDCEK189 LRRRFSSLHF 199 MVEVKGDLTA209 KKMVLALLEL219 ARQDHGALDC229 CVVVILSHGC239 QASHLQFPGA 249 VYGTDGCPVS259 VEKIVNIFNG269 TSCPSLGGKP279 KLFFIQASLP336 TPSDIFVSYS 346 TFPGFVSWRD356 PKSGSWYVET366 LDDIFEQWAH376 SEDLQSLLLR386 VANAVSVKGI 396 YKQMPCIVSM406 LRKKLFFKTS416
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Engineering a dimeric caspase-9: a re-evaluation of the induced proximity model for caspase activation. PLoS Biol. 2005 Jun;3(6):e183. | ||||
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