Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T93798 | Target Info | |||
| Target Name | Cyclic nucleotide-gated channel alpha-1 (CNGA1) | ||||
| Synonyms | cGMP-gated cation channel alpha-1; Rod photoreceptor cGMP-gated channel subunit alpha; Cyclic nucleotide-gated channel, photoreceptor; Cyclic nucleotide-gated cation channel 1; CNG1; CNG-1; CNG channel alpha-1; CNCG1; CNCG | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | CNGA1 | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Cholesterol | Ligand Info | |||||
| Structure Description | Cryo-EM structure of human Apo CNGA1 channel in K+/Ca2+ | PDB:7LFT | ||||
| Method | Electron microscopy | Resolution | 2.60 Å | Mutation | No | [1] |
| PDB Sequence |
VVIDPSGNTY
165 YNWLFCITLP175 VMYNWTMVIA185 RACFDELQSD195 YLEYWLILDY205 VSDIVYLIDM 215 FVRTRTGYLE225 QGLLVKEELK235 LINKYKSNLQ245 FKLDVLSLIP255 TDLLYFKLGW 265 NYPEIRLNRL275 LRFSRMFEFF285 QRTETRTNYP295 NIFRISNLVM305 YIVIIIHWNA 315 CVFYSISKAI325 GFGNDTWVYP335 DINDPEFGRL345 ARKYVYSLYW355 STLTLTTIGE 365 TPPPVRDSEY375 VFVVVDFLIG385 VLIFATIVGN395 IGSMISNMNA405 ARAEFQARID 415 AIKQYMHFRN425 VSKDMEKRVI435 KWFDYLWTNK445 KTVDEKEVLK455 YLPDKLRAEI 465 AINVHLDTLK475 KVRIFADCEA485 GLLVELVLKL495 QPQVYSPGDY505 ICKKGDIGRE 515 MYIIKEGKLA525 VVADDGVTQF535 VVLSDGSYFG545 EISILNIKGS555 KAGNRRTANI 565 KSIGYSDLFC575 LSKDDLMEAL585 TEYPDAKTML595 EEKGKQILMK605 |
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| Ligand Name: Cyclic Guanosine Monophosphate | Ligand Info | |||||
| Structure Description | Cryo-EM structure of human cGMP-bound CNGA1_E365Q channel in Na+/Ca2+ | PDB:7LG1 | ||||
| Method | Electron microscopy | Resolution | 2.70 Å | Mutation | Yes | [1] |
| PDB Sequence |
VVIDPSGNTY
165 YNWLFCITLP175 VMYNWTMVIA185 RACFDELQSD195 YLEYWLILDY205 VSDIVYLIDM 215 FVRTRTGYLE225 QGLLVKEELK235 LINKYKSNLQ245 FKLDVLSLIP255 TDLLYFKLGW 265 NYPEIRLNRL275 LRFSRMFEFF285 QRTETRTNYP295 NIFRISNLVM305 YIVIIIHWNA 315 CVFYSISKAI325 GFGNDTWVYP335 DINDPEFGRL345 ARKYVYSLYW355 STLTLTTIGQ 365 TPPPVRDSEY375 VFVVVDFLIG385 VLIFATIVGN395 IGSMISNMNA405 ARAEFQARID 415 AIKQYMHFRN425 VSKDMEKRVI435 KWFDYLWTNK445 KTVDEKEVLK455 YLPDKLRAEI 465 AINVHLDTLK475 KVRIFADCEA485 GLLVELVLKL495 QPQVYSPGDY505 ICKKGDIGRE 515 MYIIKEGKLA525 VVADDGVTQF535 VVLSDGSYFG545 EISILNIKGS555 KAGNRRTANI 565 KSIGYSDLFC575 LSKDDLMEAL585 TEYPDAKTML595 EEKGKQILMK605 |
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: [3H]cAMP | Ligand Info | |||||
| Structure Description | Cryo-EM structure of human rod CNGA1/B1 channel in cAMP-bound state | PDB:7RHG | ||||
| Method | Electron microscopy | Resolution | 2.88 Å | Mutation | No | [2] |
| PDB Sequence |
VVIDPSGNTY
165 YNWLFCITLP175 VMYNWTMVIA185 RACFDELQSD195 YLEYWLILDY205 VSDIVYLIDM 215 FVRTRTGYLE225 QGLLVKEELK235 LINKYKSNLQ245 FKLDVLSLIP255 TDLLYFKLGW 265 NYPEIRLNRL275 LRFSRMFEFF285 QRTETRTNYP295 NIFRISNLVM305 YIVIIIHWNA 315 CVFYSISKAI325 GFGNDTWVYP335 DINDPEFGRL345 ARKYVYSLYW355 STLTLTTIGE 365 TPPPVRDSEY375 VFVVVDFLIG385 VLIFATIVGN395 IGSMISNMNA405 ARAEFQARID 415 AIKQYMHFRN425 VSKDMEKRVI435 KWFDYLWTNK445 KTVDEKEVLK455 YLPDKLRAEI 465 AINVHLDTLK475 KVRIFADCEA485 GLLVELVLKL495 QPQVYSPGDY505 ICKKGDIGRE 515 MYIIKEGKLA525 VVADDGVTQF535 VVLSDGSYFG545 EISILNIKGS555 KAGNRRTANI 565 KSIGYSDLFC575 LSKDDLMEAL585 TEYPDAKTML595 EEKGKQILMK605 |
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CMP or .CMP2 or .CMP3 or :3CMP;style chemicals stick;color identity;select .C:507 or .C:526 or .C:535 or .C:536 or .C:543 or .C:544 or .C:545 or .C:546 or .C:548 or .C:560 or .C:561 or .C:562 or .C:563 or .C:565; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
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| Ligand Name: 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine | Ligand Info | |||||
| Structure Description | Cryo-EM structure of human Apo CNGA1 channel in K+/Ca2+ | PDB:7LFT | ||||
| Method | Electron microscopy | Resolution | 2.60 Å | Mutation | No | [1] |
| PDB Sequence |
VVIDPSGNTY
165 YNWLFCITLP175 VMYNWTMVIA185 RACFDELQSD195 YLEYWLILDY205 VSDIVYLIDM 215 FVRTRTGYLE225 QGLLVKEELK235 LINKYKSNLQ245 FKLDVLSLIP255 TDLLYFKLGW 265 NYPEIRLNRL275 LRFSRMFEFF285 QRTETRTNYP295 NIFRISNLVM305 YIVIIIHWNA 315 CVFYSISKAI325 GFGNDTWVYP335 DINDPEFGRL345 ARKYVYSLYW355 STLTLTTIGE 365 TPPPVRDSEY375 VFVVVDFLIG385 VLIFATIVGN395 IGSMISNMNA405 ARAEFQARID 415 AIKQYMHFRN425 VSKDMEKRVI435 KWFDYLWTNK445 KTVDEKEVLK455 YLPDKLRAEI 465 AINVHLDTLK475 KVRIFADCEA485 GLLVELVLKL495 QPQVYSPGDY505 ICKKGDIGRE 515 MYIIKEGKLA525 VVADDGVTQF535 VVLSDGSYFG545 EISILNIKGS555 KAGNRRTANI 565 KSIGYSDLFC575 LSKDDLMEAL585 TEYPDAKTML595 EEKGKQILMK605 |
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CPL or .CPL2 or .CPL3 or :3CPL;style chemicals stick;color identity;select .A:184 or .A:187 or .A:188 or .A:190 or .A:259 or .A:263 or .A:266 or .A:267 or .A:269 or .A:270 or .A:272 or .A:273 or .A:275 or .A:276 or .A:278 or .A:279 or .A:282 or .A:286 or .A:306 or .A:307 or .A:310 or .A:313 or .A:316 or .A:317 or .A:320 or .A:321 or .A:323 or .A:324 or .A:325 or .A:371 or .A:372 or .A:373 or .A:374 or .A:376 or .A:377 or .A:379 or .A:380 or .A:383 or .A:384 or .A:387 or .A:388 or .A:391; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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ILE184
2.913
ALA187
2.882
CYS188
3.050
ASP190
3.493
LEU259
4.135
LEU263
3.179
ASN266
2.777
TYR267
3.073
GLU269
2.334
ILE270
4.264
LEU272
2.733
ASN273
3.252
LEU275
4.311
LEU276
3.694
PHE278
4.865
SER279
4.947
PHE282
2.924
GLN286
2.684
TYR306
2.724
ILE307
3.501
ILE310
3.198
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structural mechanisms of gating and selectivity of human rod CNGA1 channel. Neuron. 2021 Apr 21;109(8):1302-1313.e4. | ||||
| REF 2 | Structural mechanisms of assembly, permeation, gating, and pharmacology of native human rod CNG channel. Neuron. 2022 Jan 5;110(1):86-95.e5. | ||||
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