Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T93266 | Target Info | |||
| Target Name | Hyperpolarization cyclic nucleotide-gated channel 1 (HCN1) | ||||
| Synonyms | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1; Brain cyclic nucleotide-gated channel 1; BCNG1; BCNG-1 | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | HCN1 | ||||
| Biochemical Class | Voltage-gated ion channel | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: [3H]cAMP | Ligand Info | |||||
| Structure Description | Human HCN1 channel in a hyperpolarized conformation | PDB:6UQF | ||||
| Method | Electron microscopy | Resolution | 3.04 Å | Mutation | No | [1] |
| PDB Sequence |
MQRQFTSMLQ
103 PGVNKFSLRM113 FGSQKAVEKE123 QERVKTAGFW133 IIHPYSDFRF143 YWDLIMLIMM 153 VGNLVIIPVG163 ITFFTEQTTT173 PWIIFNVASD183 TVCLLDLIMN193 FRTGTVNEDS 203 SEIILDPKVI213 KMNYLKSWFV223 VDFISSIPVD233 YIFLIVERAL254 RIVRFTKILC 264 LLRLLRLSRL274 IRYIHQWEEI284 FHMTYDLASA294 VVRIFNLIGM304 MLLLCHWDGC 314 LQFLVPLLQD324 FPPDCWVSLN334 EMVNDSWGKQ344 YSYALFKAMS354 HMLCIGYGAQ 364 APVSMSDLWI374 TMLSMIVGAT384 CYAMFVGHAT394 ALIQSLDSSR404 RQYQEKYKQV 414 EQYMSFHKLP424 ADMRQKIHDY434 YEHRYQGKIF444 DEENILNELN454 DPLREEIVNF 464 NCRKLVATMP474 LFANADPNFV484 TAMLSKLRFE494 VFQPGDYIIR504 EGAVGKKMYF 514 IQHGVAGVIT524 KSSKEMKLTD534 GSYFGEICLL544 TKGRRTASVR554 ADTYCRLYSL 564 SVDNFNEVLE574 EYPMMRRAFE584 TVAIDRLDRI594 GKKNSILLQK604 FQKDLNTGVF 614 NNQENEILKQ624 IVKHDREMVQ634 A
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Voltage Sensor Movements during Hyperpolarization in the HCN Channel. Cell. 2019 Dec 12;179(7):1582-1589.e7. | ||||
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