Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T92777 | Target Info | |||
| Target Name | Intestinal maltase-glucoamylase (MGAM) | ||||
| Synonyms | MGAM | ||||
| Target Type | Successful Target | ||||
| Gene Name | MGAM | ||||
| Biochemical Class | Glycosylase | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Miglitol | Ligand Info | |||||
| Structure Description | Crystal complex of N-terminal Human Maltase-Glucoamylase with miglitol | PDB:3L4W | ||||
| Method | X-ray diffraction | Resolution | 2.00 Å | Mutation | Yes | [1] |
| PDB Sequence |
VNELERINCI
16 PDQPPTKATC26 DQRGCCWNPQ36 GAVSVPWCYY46 SKNHSYHVEG56 NLVNTNAGFT 66 ARLKNLPSSP76 VFGSNVDNVL86 LTAEYQTSNR96 FHFKLTDQTN106 NRFEVPHEHV 116 QSFSGNAAAS126 LTYQVEISRQ136 PFSIKVTRRS146 NNRVLFDSSI156 GPLLFADQFL 166 QLSTRLPSTN176 VYGLGEHVHQ186 QYRHDMNWKT196 WPIFNRDTTP206 NGNGTNLYGA 216 QTFFLCLEDA226 SGLSFGVFLM236 NSNAMEVVLQ246 PAPAITYRTI256 GGILDFYVFL 266 GNTPEQVVQE276 YLELIGRPAL286 PSYWALGFHL296 SRYEYGTLDN306 MREVVERNRA 316 AQLPYDVQHA326 DIDYMDERRD336 FTYDSVDFKG346 FPEFVNELHN356 NGQKLVIIVD 366 PAISNNSSSS376 KPYGPYDRGS386 DMKIWVNSSD396 GVTPLIGEVW406 PGQTVFPDYT 416 NPNCAVWWTK426 EFELFHNQVE436 FDGIWIDMNE446 VSNFVDGSVS456 GCSTNNLNNP 466 PFTPRILDGY476 LFCKTLCMDA486 VQHWGKQYDI496 HNLYGYSMAV506 ATAEAAKTVF 516 PNKRSFILTR526 STFAGSGKFA536 AHWLGDNTAT546 WDDLRWSIPG556 VLEFNLFGIP 566 MVGPDICGFA576 LDTPEELCRR586 WMQLGAFYPF596 SRNHNGQGYK606 DQDPASFGAD 616 SLLLNSSRHY626 LNIRYTLLPY636 LYTLFFRAHS646 RGDTVARPLL656 HEFYEDNSTW 666 DVHQQFLWGP676 GLLITPVLDE686 GAEKVMAYVP696 DAVWYDYETG706 SQVRWRKQKV 716 EMELPGDKIG726 LHLRGGYIFP736 TQQPNTTTLA746 SRKNPLGLII756 ALDENKEAKG 766 ELFWDDGETK776 DTVANKVYLL786 CEFSVTQNRL796 EVNISQSTYK806 DPNNLAFNEI 816 KILGTEEPSN826 VTVKHNGVPS836 TSPTVTYDSN847 LKVAIITDID857 LLLGEAYTVE 867 WAH
|
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| Ligand Name: Kotalanol | Ligand Info | |||||
| Structure Description | Crystal complex of N-terminal Human Maltase-Glucoamylase with kotalanol | PDB:3L4V | ||||
| Method | X-ray diffraction | Resolution | 2.10 Å | Mutation | Yes | [1] |
| PDB Sequence |
VNELERINCI
16 PDQPPTKATC26 DQRGCCWNPQ36 GAVSVPWCYY46 SKNHSYHVEG56 NLVNTNAGFT 66 ARLKNLPSSP76 VFGSNVDNVL86 LTAEYQTSNR96 FHFKLTDQTN106 NRFEVPHEHV 116 QSFSGNAAAS126 LTYQVEISRQ136 PFSIKVTRRS146 NNRVLFDSSI156 GPLLFADQFL 166 QLSTRLPSTN176 VYGLGEHVHQ186 QYRHDMNWKT196 WPIFNRDTTP206 NGNGTNLYGA 216 QTFFLCLEDA226 SGLSFGVFLM236 NSNAMEVVLQ246 PAPAITYRTI256 GGILDFYVFL 266 GNTPEQVVQE276 YLELIGRPAL286 PSYWALGFHL296 SRYEYGTLDN306 MREVVERNRA 316 AQLPYDVQHA326 DIDYMDERRD336 FTYDSVDFKG346 FPEFVNELHN356 NGQKLVIIVD 366 PAISNNSSSS376 KPYGPYDRGS386 DMKIWVNSSD396 GVTPLIGEVW406 PGQTVFPDYT 416 NPNCAVWWTK426 EFELFHNQVE436 FDGIWIDMNE446 VSNFVDGSVS456 GCSTNNLNNP 466 PFTPRILDGY476 LFCKTLCMDA486 VQHWGKQYDI496 HNLYGYSMAV506 ATAEAAKTVF 516 PNKRSFILTR526 STFAGSGKFA536 AHWLGDNTAT546 WDDLRWSIPG556 VLEFNLFGIP 566 MVGPDICGFA576 LDTPEELCRR586 WMQLGAFYPF596 SRNHNGQGYK606 DQDPASFGAD 616 SLLLNSSRHY626 LNIRYTLLPY636 LYTLFFRAHS646 RGDTVARPLL656 HEFYEDNSTW 666 DVHQQFLWGP676 GLLITPVLDE686 GAEKVMAYVP696 DAVWYDYETG706 SQVRWRKQKV 716 EMELPGDKIG726 LHLRGGYIFP736 TQQPNTTTLA746 SRKNPLGLII756 ALDENKEAKG 766 ELFWDDGETK776 DTVANKVYLL786 CEFSVTQNRL796 EVNISQSTYK806 DPNNLAFNEI 816 KILGTEEPSN826 VTVKHNGVPS836 TSPTVTYDSN847 LKVAIITDID857 LLLGEAYTVE 867 WAH
|
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|
|
ASP203
2.736
THR204
4.057
THR205
4.614
TYR299
3.526
ASP327
2.425
ILE328
3.801
ILE364
3.574
ASP366
4.936
TRP406
3.691
TRP441
3.253
ASP443
3.074
MET444
3.994
|
|||||
| Ligand Name: (1S,2R,3S,4R)-1-{(1S)-2-[(2R,3S,4S)-3,4-dihydroxy-2-(hydroxymethyl)tetrahydrothiophenium-1-yl]-1-hydroxyethyl}-2,3,4,5-tetrahydroxypentyl sulfate | Ligand Info | |||||
| Structure Description | Crystal complex of N-terminal Human Maltase-Glucoamylase with NR4-8II | PDB:3L4Y | ||||
| Method | X-ray diffraction | Resolution | 1.80 Å | Mutation | Yes | [1] |
| PDB Sequence |
VNELERINCI
16 PDQPPTKATC26 DQRGCCWNPQ36 GAVSVPWCYY46 SKNHSYHVEG56 NLVNTNAGFT 66 ARLKNLPSSP76 VFGSNVDNVL86 LTAEYQTSNR96 FHFKLTDQTN106 NRFEVPHEHV 116 QSFSGNAAAS126 LTYQVEISRQ136 PFSIKVTRRS146 NNRVLFDSSI156 GPLLFADQFL 166 QLSTRLPSTN176 VYGLGEHVHQ186 QYRHDMNWKT196 WPIFNRDTTP206 NGNGTNLYGA 216 QTFFLCLEDA226 SGLSFGVFLM236 NSNAMEVVLQ246 PAPAITYRTI256 GGILDFYVFL 266 GNTPEQVVQE276 YLELIGRPAL286 PSYWALGFHL296 SRYEYGTLDN306 MREVVERNRA 316 AQLPYDVQHA326 DIDYMDERRD336 FTYDSVDFKG346 FPEFVNELHN356 NGQKLVIIVD 366 PAISNNSSSS376 KPYGPYDRGS386 DMKIWVNSSD396 GVTPLIGEVW406 PGQTVFPDYT 416 NPNCAVWWTK426 EFELFHNQVE436 FDGIWIDMNE446 VSNFVDGSVS456 GCSTNNLNNP 466 PFTPRILDGY476 LFCKTLCMDA486 VQHWGKQYDI496 HNLYGYSMAV506 ATAEAAKTVF 516 PNKRSFILTR526 STFAGSGKFA536 AHWLGDNTAT546 WDDLRWSIPG556 VLEFNLFGIP 566 MVGPDICGFA576 LDTPEELCRR586 WMQLGAFYPF596 SRNHNGQGYK606 DQDPASFGAD 616 SLLLNSSRHY626 LNIRYTLLPY636 LYTLFFRAHS646 RGDTVARPLL656 HEFYEDNSTW 666 DVHQQFLWGP676 GLLITPVLDE686 GAEKVMAYVP696 DAVWYDYETG706 SQVRWRKQKV 716 EMELPGDKIG726 LHLRGGYIFP736 TQQPNTTTLA746 SRKNPLGLII756 ALDENKEAKG 766 ELFWDDGETK776 DTVANKVYLL786 CEFSVTQNRL796 EVNISQSTYK806 DPNNLAFNEI 816 KILGTEEPSN826 VTVKHNGVPS836 TSPTVTYDSN847 LKVAIITDID857 LLLGEAYTVE 867 WAH
|
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|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .NR4 or .NR42 or .NR43 or :3NR4;style chemicals stick;color identity;select .A:203 or .A:204 or .A:205 or .A:299 or .A:327 or .A:328 or .A:364 or .A:366 or .A:406 or .A:441 or .A:443 or .A:444 or .A:448 or .A:450 or .A:526 or .A:539 or .A:542 or .A:571 or .A:575 or .A:598 or .A:600; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
ASP203
2.844
THR204
4.098
THR205
3.247
TYR299
3.474
ASP327
2.457
ILE328
3.626
ILE364
3.368
ASP366
4.992
TRP406
3.732
TRP441
3.468
ASP443
2.820
|
|||||
| Ligand Name: (1R,2S)-1-[(1S)-1,2-dihydroxyethyl]-3-[(2R,3S,4S)-3,4-dihydroxy-2-(hydroxymethyl)tetrahydrothiophenium-1-yl]-2-hydroxypropyl sulfate | Ligand Info | |||||
| Structure Description | Crystal complex of N-terminal Human Maltase-Glucoamylase with BJ2661 | PDB:3L4T | ||||
| Method | X-ray diffraction | Resolution | 1.90 Å | Mutation | Yes | [1] |
| PDB Sequence |
NELERINCIP
17 DQPPTKATCD27 QRGCCWNPQA38 VSVPWCYYSK48 NHSYHVEGNL58 VNTNAGFTAR 68 LKNLVFGSNV82 DNVLLTAEYQ92 TSNRFHFKLT102 DQTNNRFEVP112 HHVQSFSGNA 123 AASLTYQVEI133 SRQPFSIKVT143 RRSNNRVLFD153 SSIGPLLFAD163 QFLQLSTRLP 173 STNVYGLGEH183 VHQQYRHDMN193 WKTWPIFNRD203 TTPNGNGTNL213 YGAQTFFLCL 223 EDASGLSFGV233 FLMNSNAMEV243 VLQPAPAITY253 RTIGGILDFY263 VFLGNTPEQV 273 VQEYLELIGR283 PALPSYWALG293 FHLSRYEYGT303 LDNMREVVER313 NRAAQLPYDV 323 QHADIDYMDE333 RRDFTYDSVD343 FKGFPEFVNE353 LHNNGQKLVI363 IVDPAISNNS 373 SSSKPYGPYD383 RGSDMKIWVN393 SSDGVTPLIG403 EVWPGQTVFP413 DYTNPNCAVW 423 WTKEFELFHN433 QVEFDGIWID443 MNEVSNFVDG453 SVSGCSTNNL463 NNPPFTPRIL 473 DGYLFCKTLC483 MDAVQHWGKQ493 YDIHNLYGYS503 MAVATAEAAK513 TVFPNKRSFI 523 LTRSTFAGSG533 KFAAHWLGDN543 TATWDDLRWS553 IPGVLEFNLF563 GIPMVGPDIC 573 GFALDTPEEL583 CRRWMQLGAF593 YPFSRNHNGQ603 GYKDQDPASF613 GADSLLLNSS 623 RHYLNIRYTL633 LPYLYTLFFR643 AHSRGDTVAR653 PLLHEFYEDN663 STWDVHQQFL 673 WGPGLLITPV683 LDEGAEKVMA693 YVPDAVWYDY703 ETGSQVRWRK713 QKVEMELPGD 723 KIGLHLRGGY733 IFPTQQPNTT743 TLASRKNPLG753 LIIALDENKE763 AKGELFWDDG 773 ETKDTVANKV783 YLLCEFSVTQ793 NRLEVNISQS803 TYKDPNNLAF813 NEIKILGTEE 823 PSNVTVKHNG833 VPSTSPTVTY844 DSNLKVAIIT854 DIDLLLGEAY864 TVEWAH |
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .BJ1 or .BJ12 or .BJ13 or :3BJ1;style chemicals stick;color identity;select .A:203 or .A:299 or .A:327 or .A:328 or .A:364 or .A:366 or .A:406 or .A:441 or .A:443 or .A:444 or .A:448 or .A:450 or .A:526 or .A:539 or .A:542 or .A:571 or .A:575 or .A:598 or .A:600 or .A:601; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
ASP203
2.612
TYR299
3.323
ASP327
2.482
ILE328
3.625
ILE364
3.438
ASP366
4.781
TRP406
3.829
TRP441
3.290
ASP443
2.953
MET444
3.803
|
|||||
| Ligand Name: (1S,2R,3S,4S)-1-{(1S)-2-[(2R,3S,4S)-3,4-dihydroxy-2-(hydroxymethyl)tetrahydrothiophenium-1-yl]-1-hydroxyethyl}-2,3,4,5-tetrahydroxypentyl sulfate | Ligand Info | |||||
| Structure Description | Crystal complex of N-terminal Human Maltase-Glucoamylase with NR4-8 | PDB:3L4X | ||||
| Method | X-ray diffraction | Resolution | 1.90 Å | Mutation | Yes | [1] |
| PDB Sequence |
VNELERINCI
16 PDQPPTKATC26 DQRGCCWNPQ36 GAVSVPWCYY46 SKNHSYHVEG56 NLVNTNAGFT 66 ARLKNLPSSP76 VFGSNVDNVL86 LTAEYQTSNR96 FHFKLTDQTN106 NRFEVPHEHV 116 QSFSGNAAAS126 LTYQVEISRQ136 PFSIKVTRRS146 NNRVLFDSSI156 GPLLFADQFL 166 QLSTRLPSTN176 VYGLGEHVHQ186 QYRHDMNWKT196 WPIFNRDTTP206 NGNGTNLYGA 216 QTFFLCLEDA226 SGLSFGVFLM236 NSNAMEVVLQ246 PAPAITYRTI256 GGILDFYVFL 266 GNTPEQVVQE276 YLELIGRPAL286 PSYWALGFHL296 SRYEYGTLDN306 MREVVERNRA 316 AQLPYDVQHA326 DIDYMDERRD336 FTYDSVDFKG346 FPEFVNELHN356 NGQKLVIIVD 366 PAISNNSSSS376 KPYGPYDRGS386 DMKIWVNSSD396 GVTPLIGEVW406 PGQTVFPDYT 416 NPNCAVWWTK426 EFELFHNQVE436 FDGIWIDMNE446 VSNFVDGSVS456 GCSTNNLNNP 466 PFTPRILDGY476 LFCKTLCMDA486 VQHWGKQYDI496 HNLYGYSMAV506 ATAEAAKTVF 516 PNKRSFILTR526 STFAGSGKFA536 AHWLGDNTAT546 WDDLRWSIPG556 VLEFNLFGIP 566 MVGPDICGFA576 LDTPEELCRR586 WMQLGAFYPF596 SRNHNGQGYK606 DQDPASFGAD 616 SLLLNSSRHY626 LNIRYTLLPY636 LYTLFFRAHS646 RGDTVARPLL656 HEFYEDNSTW 666 DVHQQFLWGP676 GLLITPVLDE686 GAEKVMAYVP696 DAVWYDYETG706 SQVRWRKQKV 716 EMELPGDKIG726 LHLRGGYIFP736 TQQPNTTTLA746 SRKNPLGLII756 ALDENKEAKG 766 ELFWDDGETK776 DTVANKVYLL786 CEFSVTQNRL796 EVNISQSTYK806 DPNNLAFNEI 816 KILGTEEPSN826 VTVKHNGVPS836 TSPTVTYDSN847 LKVAIITDID857 LLLGEAYTVE 867 WAH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .NR3 or .NR32 or .NR33 or :3NR3;style chemicals stick;color identity;select .A:203 or .A:205 or .A:299 or .A:327 or .A:328 or .A:364 or .A:406 or .A:441 or .A:443 or .A:444 or .A:448 or .A:450 or .A:526 or .A:539 or .A:542 or .A:571 or .A:575 or .A:598 or .A:600; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| Ligand Name: Neokotalanol | Ligand Info | |||||
| Structure Description | Crystal complex of N-terminal Human Maltase-Glucoamylase with de-O-sulfonated kotalanol | PDB:3L4U | ||||
| Method | X-ray diffraction | Resolution | 1.90 Å | Mutation | Yes | [1] |
| PDB Sequence |
VNELERINCI
16 PDQPPTKATC26 DQRGCCWNPQ36 GAVSVPWCYY46 SKNHSYHVEG56 NLVNTNAGFT 66 ARLKNLPSSP76 VFGSNVDNVL86 LTAEYQTSNR96 FHFKLTDQTN106 NRFEVPHEHV 116 QSFSGNAAAS126 LTYQVEISRQ136 PFSIKVTRRS146 NNRVLFDSSI156 GPLLFADQFL 166 QLSTRLPSTN176 VYGLGEHVHQ186 QYRHDMNWKT196 WPIFNRDTTP206 NGNGTNLYGA 216 QTFFLCLEDA226 SGLSFGVFLM236 NSNAMEVVLQ246 PAPAITYRTI256 GGILDFYVFL 266 GNTPEQVVQE276 YLELIGRPAL286 PSYWALGFHL296 SRYEYGTLDN306 MREVVERNRA 316 AQLPYDVQHA326 DIDYMDERRD336 FTYDSVDFKG346 FPEFVNELHN356 NGQKLVIIVD 366 PAISNNSSSS376 KPYGPYDRGS386 DMKIWVNSSD396 GVTPLIGEVW406 PGQTVFPDYT 416 NPNCAVWWTK426 EFELFHNQVE436 FDGIWIDMNE446 VSNFVDGSVS456 GCSTNNLNNP 466 PFTPRILDGY476 LFCKTLCMDA486 VQHWGKQYDI496 HNLYGYSMAV506 ATAEAAKTVF 516 PNKRSFILTR526 STFAGSGKFA536 AHWLGDNTAT546 WDDLRWSIPG556 VLEFNLFGIP 566 MVGPDICGFA576 LDTPEELCRR586 WMQLGAFYPF596 SRNHNGQGYK606 DQDPASFGAD 616 SLLLNSSRHY626 LNIRYTLLPY636 LYTLFFRAHS646 RGDTVARPLL656 HEFYEDNSTW 666 DVHQQFLWGP676 GLLITPVLDE686 GAEKVMAYVP696 DAVWYDYETG706 SQVRWRKQKV 716 EMELPGDKIG726 LHLRGGYIFP736 TQQPNTTTLA746 SRKNPLGLII756 ALDENKEAKG 766 ELFWDDGETK776 DTVANKVYLL786 CEFSVTQNRL796 EVNISQSTYK806 DPNNLAFNEI 816 KILGTEEPSN826 VTVKHNGVPS836 QTSPTVTYDS846 NLKVAIITDI856 DLLLGEAYTV 866 EWAH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .DSK or .DSK2 or .DSK3 or :3DSK;style chemicals stick;color identity;select .A:203 or .A:204 or .A:205 or .A:299 or .A:327 or .A:328 or .A:364 or .A:366 or .A:406 or .A:441 or .A:443 or .A:444 or .A:448 or .A:450 or .A:480 or .A:526 or .A:539 or .A:542 or .A:571 or .A:575 or .A:598 or .A:600; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
ASP203
2.645
THR204
4.228
THR205
4.921
TYR299
3.566
ASP327
2.415
ILE328
3.575
ILE364
3.371
ASP366
4.956
TRP406
3.515
TRP441
3.502
ASP443
2.911
|
|||||
| Ligand Name: Diastereomer OF salacinol | Ligand Info | |||||
| Structure Description | Crystal complex of N-terminal Human Maltase-Glucoamylase with Salacinol | PDB:3L4Z | ||||
| Method | X-ray diffraction | Resolution | 2.00 Å | Mutation | Yes | [1] |
| PDB Sequence |
VNELERINCI
16 PDQPPTKATC26 DQRGCCWNPQ36 GAVSVPWCYY46 SKNHSYHVEG56 NLVNTNAGFT 66 ARLKNLPSSP76 VFGSNVDNVL86 LTAEYQTSNR96 FHFKLTDQTN106 NRFEVPHEHV 116 QSFSGNAAAS126 LTYQVEISRQ136 PFSIKVTRRS146 NNRVLFDSSI156 GPLLFADQFL 166 QLSTRLPSTN176 VYGLGEHVHQ186 QYRHDMNWKT196 WPIFNRDTTP206 NGNGTNLYGA 216 QTFFLCLEDA226 SGLSFGVFLM236 NSNAMEVVLQ246 PAPAITYRTI256 GGILDFYVFL 266 GNTPEQVVQE276 YLELIGRPAL286 PSYWALGFHL296 SRYEYGTLDN306 MREVVERNRA 316 AQLPYDVQHA326 DIDYMDERRD336 FTYDSVDFKG346 FPEFVNELHN356 NGQKLVIIVD 366 PAISNNSSSS376 KPYGPYDRGS386 DMKIWVNSSD396 GVTPLIGEVW406 PGQTVFPDYT 416 NPNCAVWWTK426 EFELFHNQVE436 FDGIWIDMNE446 VSNFVDGSVS456 GCSTNNLNNP 466 PFTPRILDGY476 LFCKTLCMDA486 VQHWGKQYDI496 HNLYGYSMAV506 ATAEAAKTVF 516 PNKRSFILTR526 STFAGSGKFA536 AHWLGDNTAT546 WDDLRWSIPG556 VLEFNLFGIP 566 MVGPDICGFA576 LDTPEELCRR586 WMQLGAFYPF596 SRNHNGQGYK606 DQDPASFGAD 616 SLLLNSSRHY626 LNIRYTLLPY636 LYTLFFRAHS646 RGDTVARPLL656 HEFYEDNSTW 666 DVHQQFLWGP676 GLLITPVLDE686 GAEKVMAYVP696 DAVWYDYETG706 SQVRWRKQKV 716 EMELPGDKIG726 LHLRGGYIFP736 TQQPNTTTLA746 SRKNPLGLII756 ALDENKEAKG 766 ELFWDDGETK776 DTVANKVYLL786 CEFSVTQNRL796 EVNISQSTYK806 DPNNLAFNEI 816 KILGTEEPSN826 VTVKHNGVPS836 TSPTVTYDSN847 LKVAIITDID857 LLLGEAYTVE 867 WAH
|
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|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .SSD or .SSD2 or .SSD3 or :3SSD;style chemicals stick;color identity;select .A:203 or .A:299 or .A:327 or .A:328 or .A:364 or .A:406 or .A:441 or .A:443 or .A:444 or .A:448 or .A:450 or .A:526 or .A:539 or .A:542 or .A:571 or .A:575 or .A:598 or .A:600; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
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| Ligand Name: Casuarine | Ligand Info | |||||
| Structure Description | Crystal complex of N-terminal Human Maltase-Glucoamylase with Casuarine | PDB:3CTT | ||||
| Method | X-ray diffraction | Resolution | 2.10 Å | Mutation | No | [2] |
| PDB Sequence |
VNELERINCI
16 PDQPPTKATC26 DQRGCCWNPQ36 GAVSVPWCYY46 SKNHSYHVEG56 NLVNTNAGFT 66 ARLKNLPSSP76 VFGSNVDNVL86 LTAEYQTSNR96 FHFKLTDQTN106 NRFEVPHEHV 116 QSFSGNAAAS126 LTYQVEISRQ136 PFSIKVTRRS146 NNRVLFDSSI156 GPLLFADQFL 166 QLSTRLPSTN176 VYGLGEHVHQ186 QYRHDMNWKT196 WPIFNRDTTP206 NGNGTNLYGA 216 QTFFLCLEDA226 SGLSFGVFLM236 NSNAMEVVLQ246 PAPAITYRTI256 GGILDFYVFL 266 GNTPEQVVQE276 YLELIGRPAL286 PSYWALGFHL296 SRYEYGTLDN306 MREVVERNRA 316 AQLPYDVQHA326 DIDYMDERRD336 FTYDSVDFKG346 FPEFVNELHN356 NGQKLVIIVD 366 PAISNNSSSS376 KPYGPYDRGS386 DMKIWVNSSD396 GVTPLIGEVW406 PGQTVFPDYT 416 NPNCAVWWTK426 EFELFHNQVE436 FDGIWIDMNE446 VSNFVDGSVS456 GCSTNNLNNP 466 PFTPRILDGY476 LFCKTLCMDA486 VQHWGKQYDI496 HNLYGYSMAV506 ATAEAAKTVF 516 PNKRSFILTR526 STFAGSGKFA536 AHWLGDNTAT546 WDDLRWSIPG556 VLEFNLFGIP 566 MVGPDICGFA576 LDTPEELCRR586 WMQLGAFYPF596 SRNHNGQGYK606 DQDPASFGAD 616 SLLLNSSRHY626 LNIRYTLLPY636 LYTLFFRAHS646 RGDTVARPLL656 HEFYEDNSTW 666 DVHQQFLWGP676 GLLITPVLDE686 GAEKVMAYVP696 DAVWYDYETG706 SQVRWRKQKV 716 EMELPGDKIG726 LHLRGGYIFP736 TQQPNTTTLA746 SRKNPLGLII756 ALDENKEAKG 766 ELFWDDGETK776 DTVANKVYLL786 CEFSVTQNRL796 EVNISQSTYK806 DPNNLAFNEI 816 KILGTEEPSN826 VTVKHNGVPS836 SPTVTYDSNL848 KVAIITDIDL858 LLGEAYTVEW 868 AH
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .3CU or .3CU2 or .3CU3 or :33CU;style chemicals stick;color identity;select .A:299 or .A:327 or .A:328 or .A:364 or .A:406 or .A:441 or .A:443 or .A:444 or .A:526 or .A:539 or .A:542 or .A:571 or .A:575 or .A:598 or .A:600 or .A:601; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | New glucosidase inhibitors from an ayurvedic herbal treatment for type 2 diabetes: structures and inhibition of human intestinal maltase-glucoamylase with compounds from Salacia reticulata. Biochemistry. 2010 Jan 26;49(3):443-51. | ||||
| REF 2 | Total syntheses of casuarine and its 6-O-alpha-glucoside: complementary inhibition towards glycoside hydrolases of the GH31 and GH37 families. Chemistry. 2009;15(7):1627-36. | ||||
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