Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T91480 | Target Info | |||
| Target Name | ATP-binding cassette transporter C8 (ABCC8) | ||||
| Synonyms | Sulfonylurea receptor 1; SUR1-type K(ATP) channel; SUR1; Kir6.2/SUR1; ATPbinding cassette subfamily C member 8; ABCC8 | ||||
| Target Type | Successful Target | ||||
| Gene Name | ABCC8 | ||||
| Biochemical Class | ABC transporter | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Adenosine triphosphate | Ligand Info | |||||
| Structure Description | Cryo-EM structure of human KATP bound to ATP and ADP in quatrefoil form | PDB:6C3O | ||||
| Method | Electron microscopy | Resolution | 3.90 Å | Mutation | No | [1] |
| PDB Sequence |
PLAFCGSENH
11 SAAYRVDQGV21 LNNGCFVDAL31 NVVPHVFLLF41 ITFPILFIGW51 GFPGHNLRWI 76 LTFMLLFVLV86 CEIAEGILSD96 GVTESHHLHL106 YMPAGMAFMA116 AVTSVVYYHN 126 IETSNFPKLL136 IALLVYWTLA146 FITKTIKFVK156 FLDHAIGFSQ166 LRFCLTGLLV 176 ILYGMLLLVE186 VNVIRVNYQR265 LCEAFDAQVR275 KDAIWQALSH293 AFGRRLVLSS 303 TFRILADLLG313 FAGPLCIFGI323 VDHLGKANAY356 VLAVLLFLAL366 LLQRTFLQAS 376 YYVAIETGIN386 LRGAIQTKIY396 NKIMHLSTSN406 LSMGEMTAGQ416 ICNLVAIDTN 426 QLMWFFFLCP436 NLWAMPVQII446 VGVILLYYIL456 GVSALIGAAV466 IILLAPVQYF 476 VATKLSQAQR486 STLEYSNERL496 KQTNEMLRGI506 KLLKLYAWEN516 IFRTRVETTR 526 RKEMTSLRAF536 AIYTSISIFM546 NTAIPIAAVL556 ITFVGHVPSV575 AFASLSLFHI 585 LVTPLFLLSS595 VVRSTVKALV605 SVQKLSEFLS615 SAEIRCCVQI681 MGGYFTWTPD 691 GIPTLSNITI701 RIPRGQLTMI711 VGQVGCGKSS721 LLLAALGEMQ731 KVSGAVFWSR 766 GPVAYASQKP776 WLLNATVEEN786 IIFESPFNKQ796 RYKMVIEACS806 LQPDIDILPH 816 GDQTQIGERG826 INLSGGQRQR836 ISVARALYQH846 ANVVFLDDPF856 SALDIHLSDH 866 LMQAGILELL876 RDDKRTVVLV886 THKLQYLPHA896 DWIIAMKDGT906 IQREGTLKDF 916 QRSECQLFEH926 WKTLEIPWRA999 CAKYLSSAGI1009 LLLSLLVFSQ1019 LLKHMVLVAI 1029 DYWLAKWTDT1061 VYAMVFTVLC1071 SLGIVLCLVT1081 SVTVEWTGLK1091 VAKRLHRSLL 1101 NRIILAPMRF1111 FETTPLGSIL1121 NRFSSDCNTI1131 DQHIPSTLEC1141 LSRSTLLCVS 1151 ALAVISYVTP1161 VFLVALLPLA1171 IVCYFIQKYF1181 RVASRDLQQL1191 DDTTQLPLLS 1201 HFAETVEGLT1211 TIRAFRYEAR1221 FQQKLLEYTD1231 SNNIASLFLT1241 AANRWLEVRM 1251 EYIGACVVLI1261 AAVTSISNSL1271 HRELSAGLVG1281 LGLTYALMVS1291 NYLNWMVRNL 1301 ADMELQLGAV1311 KRIHGLLKTE1321 AESYEGLLAP1331 SLIPKNWPDQ1341 GKIQIQNLSV 1351 RYDSSLKPVL1361 KHVNALIAPG1371 QKIGICGRTG1381 SGKSSFSLAF1391 FRMVDTFEGH 1401 IIIDGIDIAK1411 LPLHTLRSRL1421 SIILQDPVLF1431 SGTIRFNLDP1441 ERKCSDSTLW 1451 EALEIAQLKL1461 VVKALPGGLD1471 AIITEGGENF1481 SQGQRQLFCL1491 ARAFVRKTSI 1501 FIMDEATASI1511 DMATENILQK1521 VVMTAFADRT1531 VVTIAHRVHT1541 ILSADLVIVL 1551 KRGAILEFDK1561 PEKLLSRKDS1571 VFASFVRADK1581
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SER408
3.400
MET409
3.493
TRP688
3.108
THR695
4.154
GLN714
3.722
VAL715
3.215
GLY716
2.343
CYS717
3.071
GLY718
3.027
LYS719
3.136
SER720
2.482
SER721
2.486
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| Ligand Name: adenosine diphosphate | Ligand Info | |||||
| Structure Description | Cryo-EM structure of human KATP bound to ATP and ADP in quatrefoil form | PDB:6C3O | ||||
| Method | Electron microscopy | Resolution | 3.90 Å | Mutation | No | [1] |
| PDB Sequence |
PLAFCGSENH
11 SAAYRVDQGV21 LNNGCFVDAL31 NVVPHVFLLF41 ITFPILFIGW51 GFPGHNLRWI 76 LTFMLLFVLV86 CEIAEGILSD96 GVTESHHLHL106 YMPAGMAFMA116 AVTSVVYYHN 126 IETSNFPKLL136 IALLVYWTLA146 FITKTIKFVK156 FLDHAIGFSQ166 LRFCLTGLLV 176 ILYGMLLLVE186 VNVIRVNYQR265 LCEAFDAQVR275 KDAIWQALSH293 AFGRRLVLSS 303 TFRILADLLG313 FAGPLCIFGI323 VDHLGKANAY356 VLAVLLFLAL366 LLQRTFLQAS 376 YYVAIETGIN386 LRGAIQTKIY396 NKIMHLSTSN406 LSMGEMTAGQ416 ICNLVAIDTN 426 QLMWFFFLCP436 NLWAMPVQII446 VGVILLYYIL456 GVSALIGAAV466 IILLAPVQYF 476 VATKLSQAQR486 STLEYSNERL496 KQTNEMLRGI506 KLLKLYAWEN516 IFRTRVETTR 526 RKEMTSLRAF536 AIYTSISIFM546 NTAIPIAAVL556 ITFVGHVPSV575 AFASLSLFHI 585 LVTPLFLLSS595 VVRSTVKALV605 SVQKLSEFLS615 SAEIRCCVQI681 MGGYFTWTPD 691 GIPTLSNITI701 RIPRGQLTMI711 VGQVGCGKSS721 LLLAALGEMQ731 KVSGAVFWSR 766 GPVAYASQKP776 WLLNATVEEN786 IIFESPFNKQ796 RYKMVIEACS806 LQPDIDILPH 816 GDQTQIGERG826 INLSGGQRQR836 ISVARALYQH846 ANVVFLDDPF856 SALDIHLSDH 866 LMQAGILELL876 RDDKRTVVLV886 THKLQYLPHA896 DWIIAMKDGT906 IQREGTLKDF 916 QRSECQLFEH926 WKTLEIPWRA999 CAKYLSSAGI1009 LLLSLLVFSQ1019 LLKHMVLVAI 1029 DYWLAKWTDT1061 VYAMVFTVLC1071 SLGIVLCLVT1081 SVTVEWTGLK1091 VAKRLHRSLL 1101 NRIILAPMRF1111 FETTPLGSIL1121 NRFSSDCNTI1131 DQHIPSTLEC1141 LSRSTLLCVS 1151 ALAVISYVTP1161 VFLVALLPLA1171 IVCYFIQKYF1181 RVASRDLQQL1191 DDTTQLPLLS 1201 HFAETVEGLT1211 TIRAFRYEAR1221 FQQKLLEYTD1231 SNNIASLFLT1241 AANRWLEVRM 1251 EYIGACVVLI1261 AAVTSISNSL1271 HRELSAGLVG1281 LGLTYALMVS1291 NYLNWMVRNL 1301 ADMELQLGAV1311 KRIHGLLKTE1321 AESYEGLLAP1331 SLIPKNWPDQ1341 GKIQIQNLSV 1351 RYDSSLKPVL1361 KHVNALIAPG1371 QKIGICGRTG1381 SGKSSFSLAF1391 FRMVDTFEGH 1401 IIIDGIDIAK1411 LPLHTLRSRL1421 SIILQDPVLF1431 SGTIRFNLDP1441 ERKCSDSTLW 1451 EALEIAQLKL1461 VVKALPGGLD1471 AIITEGGENF1481 SQGQRQLFCL1491 ARAFVRKTSI 1501 FIMDEATASI1511 DMATENILQK1521 VVMTAFADRT1531 VVTIAHRVHT1541 ILSADLVIVL 1551 KRGAILEFDK1561 PEKLLSRKDS1571 VFASFVRADK1581
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Molecular structure of human KATP in complex with ATP and ADP. Elife. 2017 Dec 29;6:e32481. | ||||
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