Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T90439 | Target Info | |||
| Target Name | Jagged-2 protein (JAG2) | ||||
| Synonyms | hJ2; Protein jagged-2; Jagged2 | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | JAG2 | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: alpha-L-Fucose | Ligand Info | |||||
| Structure Description | Human Jagged2 C2-EGF3 | PDB:5MW7 | ||||
| Method | X-ray diffraction | Resolution | 2.80 Å | Mutation | No | [1] |
| PDB Sequence |
MGYFELQLSA
36 LRNVNGELLS46 GACCDCDECD68 TYVRVCLKEY78 QAKVTPTGPC88 SYGHGATPVL 98 GGNSFYLPPA108 GAAGDRARAR118 ARAGGDQDPG128 LVVIPFQFAW138 PRSFTLIVEA 148 WDWDNNEELL162 IERVSHAGMI172 NPEDRWKSLH182 FSGHVAHLEL192 QIRVRCDENY 202 YSATCNKFCR212 PRNDFFGHYT222 CDQYGNKACM232 DGWMGKECKE242 AVCKQGCNLL 252 HGGCTVPGEC262 RCSYGWQGRF272 CDECVPYPGC282 VHGSCVEPWQ292 CNCETNWGGL 302 LCDKDLNYCG312 SHHPCTNGGT322 CINAEPDQYR332 CT
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structural and functional dissection of the interplay between lipid and Notch binding by human Notch ligands. EMBO J. 2017 Aug 1;36(15):2204-2215. | ||||
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