Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T85801 | Target Info | |||
| Target Name | Pseudomonas Phosphomannomutase/phosphoglucomutase (Pseudo algC) | ||||
| Synonyms | algC; PMM/PGM; PMM / PGM | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | Pseudo algC | ||||
| Biochemical Class | Intramolecular transferases | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Alpha-D-Glucose-1-Phosphate | Ligand Info | |||||
| Structure Description | Enzyme-ligand complex of P. aeruginosa PMM/PGM | PDB:1P5D | ||||
| Method | X-ray diffraction | Resolution | 1.60 Å | Mutation | Yes | [1] |
| PDB Sequence |
LPASIFRAYD
18 IRGVVGDTLT28 AETAYWIGRA38 IGSESLARGE48 PCVAVGRDGR58 LSGPELVKQL 68 IQGLVDCGCQ78 VSDVGMVPTP88 VLYYAANVLE98 GKSGVMLTGH109 NPPDYNGFKI 119 VVAGETLANE129 QIQALRERIE139 KNDLASGVGS149 VEQVDILPRY159 FKQIRDDIAM 169 AKPMKVVVDC179 GNGVAGVIAP189 QLIEALGCSV199 IPLYCEVDGN209 FPNHHPDPGK 219 PENLKDLIAK229 VKAENADLGL239 AFDGDGDRVG249 VVTNTGTIIY259 PDRLLMLFAK 269 DVVSRNPGAD279 IIFDVKCTRR289 LIALISGYGG299 RPVMWKTGHS309 LIKKKMKETG 319 ALLAGEMSGH329 VFFKERWFGF339 DDGIYSAARL349 LEILSQDQRD359 SEHVFSAFPS 369 DISTPEINIT379 VTEDSKFAII389 EALQRDAQWG399 EGNITTLDGV409 RVDYPKGWGL 419 VRASNTTPVL429 VLRFEADTEE439 ELERIKTVFR449 NQLKAVDSSL459 PVPF |
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: L-serine-O-phosphate | Ligand Info | |||||
| Structure Description | Enzyme-ligand complex of P. aeruginosa PMM/PGM | PDB:1P5D | ||||
| Method | X-ray diffraction | Resolution | 1.60 Å | Mutation | Yes | [1] |
| PDB Sequence |
LPASIFRAYD
18 IRGVVGDTLT28 AETAYWIGRA38 IGSESLARGE48 PCVAVGRDGR58 LSGPELVKQL 68 IQGLVDCGCQ78 VSDVGMVPTP88 VLYYAANVLE98 GKSGVMLTGH109 NPPDYNGFKI 119 VVAGETLANE129 QIQALRERIE139 KNDLASGVGS149 VEQVDILPRY159 FKQIRDDIAM 169 AKPMKVVVDC179 GNGVAGVIAP189 QLIEALGCSV199 IPLYCEVDGN209 FPNHHPDPGK 219 PENLKDLIAK229 VKAENADLGL239 AFDGDGDRVG249 VVTNTGTIIY259 PDRLLMLFAK 269 DVVSRNPGAD279 IIFDVKCTRR289 LIALISGYGG299 RPVMWKTGHS309 LIKKKMKETG 319 ALLAGEMSGH329 VFFKERWFGF339 DDGIYSAARL349 LEILSQDQRD359 SEHVFSAFPS 369 DISTPEINIT379 VTEDSKFAII389 EALQRDAQWG399 EGNITTLDGV409 RVDYPKGWGL 419 VRASNTTPVL429 VLRFEADTEE439 ELERIKTVFR449 NQLKAVDSSL459 PVPF |
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: Alpha-D-Glucose-6-Phosphate | Ligand Info | |||||
| Structure Description | Enzyme-ligand complex of P. aeruginosa PMM/PGM | PDB:1P5G | ||||
| Method | X-ray diffraction | Resolution | 1.61 Å | Mutation | No | [1] |
| PDB Sequence |
LPASIFRAYD
18 IRGVVGDTLT28 AETAYWIGRA38 IGSESLARGE48 PCVAVGRDGR58 LSGPELVKQL 68 IQGLVDCGCQ78 VSDVGMVPTP88 VLYYAANVLE98 GKSGVMLTGH109 NPPDYNGFKI 119 VVAGETLANE129 QIQALRERIE139 KNDLASGVGS149 VEQVDILPRY159 FKQIRDDIAM 169 AKPMKVVVDC179 GNGVAGVIAP189 QLIEALGCSV199 IPLYCEVDGN209 FPNHHPDPGK 219 PENLKDLIAK229 VKAENADLGL239 AFDGDGDRVG249 VVTNTGTIIY259 PDRLLMLFAK 269 DVVSRNPGAD279 IIFDVKCTRR289 LIALISGYGG299 RPVMWKTGHS309 LIKKKMKETG 319 ALLAGEMSGH329 VFFKERWFGF339 DDGIYSAARL349 LEILSQDQRD359 SEHVFSAFPS 369 DISTPEINIT379 VTEDSKFAII389 EALQRDAQWG399 EGNITTLDGV409 RVDYPKGWGL 419 VRASNTTPVL429 VLRFEADTEE439 ELERIKTVFR449 NQLKAVDSSL459 PVPF |
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .G6P or .G6P2 or .G6P3 or :3G6P;style chemicals stick;color identity;select .X:17 or .X:109 or .X:118 or .X:247 or .X:285 or .X:306 or .X:307 or .X:308 or .X:325 or .X:327 or .X:329 or .X:375 or .X:421 or .X:422 or .X:423 or .X:424 or .X:425 or .X:426 or .X:430; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: Alpha-D-Mannose-6-Phosphate | Ligand Info | |||||
| Structure Description | Enzyme-ligand complex of P. aeruginosa PMM/PGM | PDB:1PCM | ||||
| Method | X-ray diffraction | Resolution | 1.90 Å | Mutation | Yes | [1] |
| PDB Sequence |
LPASIFRAYD
18 IRGVVGDTLT28 AETAYWIGRA38 IGSESLARGE48 PCVAVGRDGR58 LSGPELVKQL 68 IQGLVDCGCQ78 VSDVGMVPTP88 VLYYAANVLE98 GKSGVMLTGH109 NPPDYNGFKI 119 VVAGETLANE129 QIQALRERIE139 KNDLASGVGS149 VEQVDILPRY159 FKQIRDDIAM 169 AKPMKVVVDC179 GNGVAGVIAP189 QLIEALGCSV199 IPLYCEVDGN209 FPNHHPDPGK 219 PENLKDLIAK229 VKAENADLGL239 AFDGDGDRVG249 VVTNTGTIIY259 PDRLLMLFAK 269 DVVSRNPGAD279 IIFDVKCTRR289 LIALISGYGG299 RPVMWKTGHS309 LIKKKMKETG 319 ALLAGEMSGH329 VFFKERWFGF339 DDGIYSAARL349 LEILSQDQRD359 SEHVFSAFPS 369 DISTPEINIT379 VTEDSKFAII389 EALQRDAQWG399 EGNITTLDGV409 RVDYPKGWGL 419 VRASNTTPVL429 VLRFEADTEE439 ELERIKTVFR449 NQLKAVDSSL459 PVPF |
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .M6P or .M6P2 or .M6P3 or :3M6P;style chemicals stick;color identity;select .X:17 or .X:18 or .X:109 or .X:285 or .X:306 or .X:307 or .X:308 or .X:325 or .X:327 or .X:329 or .X:375 or .X:421 or .X:422 or .X:423 or .X:424 or .X:425 or .X:426 or .X:430; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: Ribose-1-Phosphate | Ligand Info | |||||
| Structure Description | Complex of PMM/PGM with ribose 1-phosphate | PDB:2H4L | ||||
| Method | X-ray diffraction | Resolution | 2.40 Å | Mutation | Yes | [2] |
| PDB Sequence |
LPASIFRAYD
18 IRGVVGDTLT28 AETAYWIGRA38 IGSESLARGE48 PCVAVGRDGR58 LSGPELVKQL 68 IQGLVDCGCQ78 VSDVGMVPTP88 VLYYAANVLE98 GKSGVMLTGH109 NPPDYNGFKI 119 VVAGETLANE129 QIQALRERIE139 KNDLASGVGS149 VEQVDILPRY159 FKQIRDDIAM 169 AKPMKVVVDC179 GNGVAGVIAP189 QLIEALGCSV199 IPLYCEVDGN209 FPNHHPDPGK 219 PENLKDLIAK229 VKAENADLGL239 AFDGDGDRVG249 VVTNTGTIIY259 PDRLLMLFAK 269 DVVSRNPGAD279 IIFDVKCTRR289 LIALISGYGG299 RPVMWKTGHS309 LIKKKMKETG 319 ALLAGEMSGH329 VFFKERWFGF339 DDGIYSAARL349 LEILSQDQRD359 SEHVFSAFPS 369 DISTPEINIT379 VTEDSKFAII389 EALQRDAQWG399 EGNITTLDGV409 RVDYPKGWGL 419 VRASNTTPVL429 VLRFEADTEE439 ELERIKTVFR449 NQLKAVDSSL459 PVPF |
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .R1P or .R1P2 or .R1P3 or :3R1P;style chemicals stick;color identity;select .X:17 or .X:18 or .X:20 or .X:285 or .X:306 or .X:307 or .X:308 or .X:325 or .X:327 or .X:329 or .X:421 or .X:422 or .X:423 or .X:424 or .X:425 or .X:426 or .X:430; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: alpha-D-Xylose 1-phosphate | Ligand Info | |||||
| Structure Description | Complex of the enzyme PMM/PGM with xylose 1-phosphate | PDB:2H5A | ||||
| Method | X-ray diffraction | Resolution | 1.72 Å | Mutation | Yes | [2] |
| PDB Sequence |
LPASIFRAYD
18 IRGVVGDTLT28 AETAYWIGRA38 IGSESLARGE48 PCVAVGRDGR58 LSGPELVKQL 68 IQGLVDCGCQ78 VSDVGMVPTP88 VLYYAANVLE98 GKSGVMLTGH109 NPPDYNGFKI 119 VVAGETLANE129 QIQALRERIE139 KNDLASGVGS149 VEQVDILPRY159 FKQIRDDIAM 169 AKPMKVVVDC179 GNGVAGVIAP189 QLIEALGCSV199 IPLYCEVDGN209 FPNHHPDPGK 219 PENLKDLIAK229 VKAENADLGL239 AFDGDGDRVG249 VVTNTGTIIY259 PDRLLMLFAK 269 DVVSRNPGAD279 IIFDVKCTRR289 LIALISGYGG299 RPVMWKTGHS309 LIKKKMKETG 319 ALLAGEMSGH329 VFFKERWFGF339 DDGIYSAARL349 LEILSQDQRD359 SEHVFSAFPS 369 DISTPEINIT379 VTEDSKFAII389 EALQRDAQWG399 EGNITTLDGV409 RVDYPKGWGL 419 VRASNTTPVL429 VLRFEADTEE439 ELERIKTVFR449 NQLKAVDSSL459 PVPF |
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .X1P or .X1P2 or .X1P3 or :3X1P;style chemicals stick;color identity;select .X:17 or .X:283 or .X:285 or .X:306 or .X:307 or .X:308 or .X:325 or .X:327 or .X:329 or .X:421 or .X:422 or .X:423 or .X:424 or .X:425 or .X:426 or .X:430; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: alpha-D-mannose 1-phosphate | Ligand Info | |||||
| Structure Description | Enzyme-ligand complex of P. aeruginosa PMM/PGM | PDB:1PCJ | ||||
| Method | X-ray diffraction | Resolution | 2.00 Å | Mutation | Yes | [1] |
| PDB Sequence |
APTLPASIFR
15 AYDIRGVVGD25 TLTAETAYWI35 GRAIGSESLA45 RGEPCVAVGR55 DGRLSGPELV 65 KQLIQGLVDC75 GCQVSDVGMV85 PTPVLYYAAN95 VLEGKSGVML105 TGHNPPDYNG 116 FKIVVAGETL126 ANEQIQALRE136 RIEKNDLASG146 VGSVEQVDIL156 PRYFKQIRDD 166 IAMAKPMKVV176 VDCGNGVAGV186 IAPQLIEALG196 CSVIPLYCEV206 DGNFPNHHPD 216 PGKPENLKDL226 IAKVKAENAD236 LGLAFDGDGD246 RVGVVTNTGT256 IIYPDRLLML 266 FAKDVVSRNP276 GADIIFDVKC286 TRRLIALISG296 YGGRPVMWKT306 GHSLIKKKMK 316 ETGALLAGEM326 SGHVFFKERW336 FGFDDGIYSA346 ARLLEILSQD356 QRDSEHVFSA 366 FPSDISTPEI376 NITVTEDSKF386 AIIEALQRDA396 QWGEGNITTL406 DGVRVDYPKG 416 WGLVRASNTT426 PVLVLRFEAD436 TEEELERIKT446 VFRNQLKAVD456 SSLPVPF |
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .M1P or .M1P2 or .M1P3 or :3M1P;style chemicals stick;color identity;select .X:17 or .X:20 or .X:247 or .X:283 or .X:285 or .X:306 or .X:307 or .X:308 or .X:325 or .X:327 or .X:329 or .X:421 or .X:422 or .X:423 or .X:424 or .X:425 or .X:426 or .X:430; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
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| Ligand Name: [(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(phosphonooxymethyl)oxan-2-yl] hydrogen phosphate | Ligand Info | |||||
| Structure Description | PMM/PGM S108D mutant with alpha-d-glucose 1,6-bisphosphate bound | PDB:2FKM | ||||
| Method | X-ray diffraction | Resolution | 1.90 Å | Mutation | Yes | [3] |
| PDB Sequence |
PASIFRAYDI
19 RGVVGDTLTA29 ETAYWIGRAI39 GSESLARGEP49 CVAVGRDGRL59 SGPELVKQLI 69 QGLVDCGCQV79 SDVGMVPTPV89 LYYAANVLEG99 KSGVMLTGDH109 NPPDYNGFKI 119 VVAGETLANE129 QIQALRERIE139 KNDLASGVGS149 VEQVDILPRY159 FKQIRDDIAM 169 AKPMKVVVDC179 GNGVAGVIAP189 QLIEALGCSV199 IPLYCEVDGN209 FPNHHPDPGK 219 PENLKDLIAK229 VKAENADLGL239 AFDGDGDRVG249 VVTNTGTIIY259 PDRLLMLFAK 269 DVVSRNPGAD279 IIFDVKCTRR289 LIALISGYGG299 RPVMWKTGHS309 LIKKKMKETG 319 ALLAGEMSGH329 VFFKERWFGF339 DDGIYSAARL349 LEILSQDQRD359 SEHVFSAFPS 369 DISTPEINIT379 VTEDSKFAII389 EALQRDAQWG399 EGNITTLDGV409 RVDYPKGWGL 419 VRASNTTPVL429 VLRFEADTEE439 ELERIKTVFR449 NQLKAVDSSL459 PVPF |
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .G16 or .G162 or .G163 or :3G16;style chemicals stick;color identity;select .X:15 or .X:17 or .X:18 or .X:20 or .X:108 or .X:109 or .X:118 or .X:246 or .X:247 or .X:283 or .X:285 or .X:306 or .X:307 or .X:308 or .X:325 or .X:327 or .X:329 or .X:421 or .X:422 or .X:423 or .X:424 or .X:425 or .X:426 or .X:430; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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ARG15
4.449
TYR17
2.519
ASP18
4.141
ARG20
4.469
ASP108
3.056
HIS109
4.255
LYS118
3.163
ASP246
3.903
ARG247
2.965
ASP283
4.873
LYS285
3.478
THR306
3.416
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structural basis of diverse substrate recognition by the enzyme PMM/PGM from P. aeruginosa. Structure. 2004 Jan;12(1):55-63. | ||||
| REF 2 | Complexes of the enzyme phosphomannomutase/phosphoglucomutase with a slow substrate and an inhibitor. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Aug 1;62(Pt 8):722-6. | ||||
| REF 3 | The reaction of phosphohexomutase from Pseudomonas aeruginosa: structural insights into a simple processive enzyme. J Biol Chem. 2006 Jun 2;281(22):15564-71. | ||||
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