Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T85801 | Target Info | |||
| Target Name | Pseudomonas Phosphomannomutase/phosphoglucomutase (Pseudo algC) | ||||
| Synonyms | algC; PMM/PGM; PMM / PGM | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | Pseudo algC | ||||
| Biochemical Class | Intramolecular transferases | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | L-serine-O-phosphate | Ligand Info | |||
| Canonical SMILES | C(C(C(=O)O)N)OP(=O)(O)O | ||||
| InChI | 1S/C3H8NO6P/c4-2(3(5)6)1-10-11(7,8)9/h2H,1,4H2,(H,5,6)(H2,7,8,9)/t2-/m0/s1 | ||||
| InChIKey | BZQFBWGGLXLEPQ-REOHCLBHSA-N | ||||
| PubChem Compound ID | 68841 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 1P5D Enzyme-ligand complex of P. aeruginosa PMM/PGM | ||||||
| Method | X-ray diffraction | Resolution | 1.60 Å | Mutation | Yes | [1] |
| PDB Sequence |
LPASIFRAYD
18 IRGVVGDTLT28 AETAYWIGRA38 IGSESLARGE48 PCVAVGRDGR58 LSGPELVKQL 68 IQGLVDCGCQ78 VSDVGMVPTP88 VLYYAANVLE98 GKSGVMLTGH109 NPPDYNGFKI 119 VVAGETLANE129 QIQALRERIE139 KNDLASGVGS149 VEQVDILPRY159 FKQIRDDIAM 169 AKPMKVVVDC179 GNGVAGVIAP189 QLIEALGCSV199 IPLYCEVDGN209 FPNHHPDPGK 219 PENLKDLIAK229 VKAENADLGL239 AFDGDGDRVG249 VVTNTGTIIY259 PDRLLMLFAK 269 DVVSRNPGAD279 IIFDVKCTRR289 LIALISGYGG299 RPVMWKTGHS309 LIKKKMKETG 319 ALLAGEMSGH329 VFFKERWFGF339 DDGIYSAARL349 LEILSQDQRD359 SEHVFSAFPS 369 DISTPEINIT379 VTEDSKFAII389 EALQRDAQWG399 EGNITTLDGV409 RVDYPKGWGL 419 VRASNTTPVL429 VLRFEADTEE439 ELERIKTVFR449 NQLKAVDSSL459 PVPF |
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| PDB ID: 1P5G Enzyme-ligand complex of P. aeruginosa PMM/PGM | ||||||
| Method | X-ray diffraction | Resolution | 1.61 Å | Mutation | No | [1] |
| PDB Sequence |
LPASIFRAYD
18 IRGVVGDTLT28 AETAYWIGRA38 IGSESLARGE48 PCVAVGRDGR58 LSGPELVKQL 68 IQGLVDCGCQ78 VSDVGMVPTP88 VLYYAANVLE98 GKSGVMLTGH109 NPPDYNGFKI 119 VVAGETLANE129 QIQALRERIE139 KNDLASGVGS149 VEQVDILPRY159 FKQIRDDIAM 169 AKPMKVVVDC179 GNGVAGVIAP189 QLIEALGCSV199 IPLYCEVDGN209 FPNHHPDPGK 219 PENLKDLIAK229 VKAENADLGL239 AFDGDGDRVG249 VVTNTGTIIY259 PDRLLMLFAK 269 DVVSRNPGAD279 IIFDVKCTRR289 LIALISGYGG299 RPVMWKTGHS309 LIKKKMKETG 319 ALLAGEMSGH329 VFFKERWFGF339 DDGIYSAARL349 LEILSQDQRD359 SEHVFSAFPS 369 DISTPEINIT379 VTEDSKFAII389 EALQRDAQWG399 EGNITTLDGV409 RVDYPKGWGL 419 VRASNTTPVL429 VLRFEADTEE439 ELERIKTVFR449 NQLKAVDSSL459 PVPF |
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| PDB ID: 2H5A Complex of the enzyme PMM/PGM with xylose 1-phosphate | ||||||
| Method | X-ray diffraction | Resolution | 1.72 Å | Mutation | Yes | [2] |
| PDB Sequence |
LPASIFRAYD
18 IRGVVGDTLT28 AETAYWIGRA38 IGSESLARGE48 PCVAVGRDGR58 LSGPELVKQL 68 IQGLVDCGCQ78 VSDVGMVPTP88 VLYYAANVLE98 GKSGVMLTGH109 NPPDYNGFKI 119 VVAGETLANE129 QIQALRERIE139 KNDLASGVGS149 VEQVDILPRY159 FKQIRDDIAM 169 AKPMKVVVDC179 GNGVAGVIAP189 QLIEALGCSV199 IPLYCEVDGN209 FPNHHPDPGK 219 PENLKDLIAK229 VKAENADLGL239 AFDGDGDRVG249 VVTNTGTIIY259 PDRLLMLFAK 269 DVVSRNPGAD279 IIFDVKCTRR289 LIALISGYGG299 RPVMWKTGHS309 LIKKKMKETG 319 ALLAGEMSGH329 VFFKERWFGF339 DDGIYSAARL349 LEILSQDQRD359 SEHVFSAFPS 369 DISTPEINIT379 VTEDSKFAII389 EALQRDAQWG399 EGNITTLDGV409 RVDYPKGWGL 419 VRASNTTPVL429 VLRFEADTEE439 ELERIKTVFR449 NQLKAVDSSL459 PVPF |
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| PDB ID: 1PCM Enzyme-ligand complex of P. aeruginosa PMM/PGM | ||||||
| Method | X-ray diffraction | Resolution | 1.90 Å | Mutation | Yes | [1] |
| PDB Sequence |
LPASIFRAYD
18 IRGVVGDTLT28 AETAYWIGRA38 IGSESLARGE48 PCVAVGRDGR58 LSGPELVKQL 68 IQGLVDCGCQ78 VSDVGMVPTP88 VLYYAANVLE98 GKSGVMLTGH109 NPPDYNGFKI 119 VVAGETLANE129 QIQALRERIE139 KNDLASGVGS149 VEQVDILPRY159 FKQIRDDIAM 169 AKPMKVVVDC179 GNGVAGVIAP189 QLIEALGCSV199 IPLYCEVDGN209 FPNHHPDPGK 219 PENLKDLIAK229 VKAENADLGL239 AFDGDGDRVG249 VVTNTGTIIY259 PDRLLMLFAK 269 DVVSRNPGAD279 IIFDVKCTRR289 LIALISGYGG299 RPVMWKTGHS309 LIKKKMKETG 319 ALLAGEMSGH329 VFFKERWFGF339 DDGIYSAARL349 LEILSQDQRD359 SEHVFSAFPS 369 DISTPEINIT379 VTEDSKFAII389 EALQRDAQWG399 EGNITTLDGV409 RVDYPKGWGL 419 VRASNTTPVL429 VLRFEADTEE439 ELERIKTVFR449 NQLKAVDSSL459 PVPF |
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .SEP or .SEP2 or .SEP3 or :3SEP;style chemicals stick;color identity;select .X:18 or .X:20 or .X:56 or .X:58 or .X:106 or .X:107 or .X:109 or .X:110 or .X:118 or .X:215 or .X:242 or .X:243 or .X:244 or .X:246 or .X:329; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
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| PDB ID: 1PCJ Enzyme-ligand complex of P. aeruginosa PMM/PGM | ||||||
| Method | X-ray diffraction | Resolution | 2.00 Å | Mutation | Yes | [1] |
| PDB Sequence |
APTLPASIFR
15 AYDIRGVVGD25 TLTAETAYWI35 GRAIGSESLA45 RGEPCVAVGR55 DGRLSGPELV 65 KQLIQGLVDC75 GCQVSDVGMV85 PTPVLYYAAN95 VLEGKSGVML105 TGHNPPDYNG 116 FKIVVAGETL126 ANEQIQALRE136 RIEKNDLASG146 VGSVEQVDIL156 PRYFKQIRDD 166 IAMAKPMKVV176 VDCGNGVAGV186 IAPQLIEALG196 CSVIPLYCEV206 DGNFPNHHPD 216 PGKPENLKDL226 IAKVKAENAD236 LGLAFDGDGD246 RVGVVTNTGT256 IIYPDRLLML 266 FAKDVVSRNP276 GADIIFDVKC286 TRRLIALISG296 YGGRPVMWKT306 GHSLIKKKMK 316 ETGALLAGEM326 SGHVFFKERW336 FGFDDGIYSA346 ARLLEILSQD356 QRDSEHVFSA 366 FPSDISTPEI376 NITVTEDSKF386 AIIEALQRDA396 QWGEGNITTL406 DGVRVDYPKG 416 WGLVRASNTT426 PVLVLRFEAD436 TEEELERIKT446 VFRNQLKAVD456 SSLPVPF |
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .SEP or .SEP2 or .SEP3 or :3SEP;style chemicals stick;color identity;select .X:18 or .X:20 or .X:56 or .X:58 or .X:106 or .X:107 or .X:109 or .X:110 or .X:118 or .X:215 or .X:242 or .X:243 or .X:244 or .X:246 or .X:247 or .X:329; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
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| PDB ID: 3BKQ Structure of the P368G mutant of PMM/PGM in complex with its substrate | ||||||
| Method | X-ray diffraction | Resolution | 2.05 Å | Mutation | Yes | [3] |
| PDB Sequence |
APTLPASIFR
15 AYDIRGVVGD25 TLTAETAYWI35 GRAIGSESLA45 RGEPCVAVGR55 DGRLSGPELV 65 KQLIQGLVDC75 GCQVSDVGMV85 PTPVLYYAAN95 VLEGKSGVML105 TGHNPPDYNG 116 FKIVVAGETL126 ANEQIQALRE136 RIEKNDLASG146 VGSVEQVDIL156 PRYFKQIRDD 166 IAMAKPMKVV176 VDCGNGVAGV186 IAPQLIEALG196 CSVIPLYCEV206 DGNFPNHHPD 216 PGKPENLKDL226 IAKVKAENAD236 LGLAFDGDGD246 RVGVVTNTGT256 IIYPDRLLML 266 FAKDVVSRNP276 GADIIFDVKC286 TRRLIALISG296 YGGRPVMWKT306 GHSLIKKKMK 316 ETGALLAGEM326 SGHVFFKERW336 FGFDDGIYSA346 ARLLEILSQD356 QRDSEHVFSA 366 FGSDISTPEI376 NITVTEDSKF386 AIIEALQRDA396 QWGEGNITTL406 DGVRVDYPKG 416 WGLVRASNTT426 PVLVLRFEAD436 TEEELERIKT446 VFRNQLKAVD456 SSLPVPF |
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .SEP or .SEP2 or .SEP3 or :3SEP;style chemicals stick;color identity;select .X:18 or .X:56 or .X:58 or .X:106 or .X:107 or .X:109 or .X:110 or .X:118 or .X:215 or .X:242 or .X:243 or .X:244 or .X:246 or .X:247 or .X:329; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
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| PDB ID: 2H4L Complex of PMM/PGM with ribose 1-phosphate | ||||||
| Method | X-ray diffraction | Resolution | 2.40 Å | Mutation | Yes | [2] |
| PDB Sequence |
LPASIFRAYD
18 IRGVVGDTLT28 AETAYWIGRA38 IGSESLARGE48 PCVAVGRDGR58 LSGPELVKQL 68 IQGLVDCGCQ78 VSDVGMVPTP88 VLYYAANVLE98 GKSGVMLTGH109 NPPDYNGFKI 119 VVAGETLANE129 QIQALRERIE139 KNDLASGVGS149 VEQVDILPRY159 FKQIRDDIAM 169 AKPMKVVVDC179 GNGVAGVIAP189 QLIEALGCSV199 IPLYCEVDGN209 FPNHHPDPGK 219 PENLKDLIAK229 VKAENADLGL239 AFDGDGDRVG249 VVTNTGTIIY259 PDRLLMLFAK 269 DVVSRNPGAD279 IIFDVKCTRR289 LIALISGYGG299 RPVMWKTGHS309 LIKKKMKETG 319 ALLAGEMSGH329 VFFKERWFGF339 DDGIYSAARL349 LEILSQDQRD359 SEHVFSAFPS 369 DISTPEINIT379 VTEDSKFAII389 EALQRDAQWG399 EGNITTLDGV409 RVDYPKGWGL 419 VRASNTTPVL429 VLRFEADTEE439 ELERIKTVFR449 NQLKAVDSSL459 PVPF |
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .SEP or .SEP2 or .SEP3 or :3SEP;style chemicals stick;color identity;select .X:18 or .X:20 or .X:56 or .X:58 or .X:106 or .X:107 or .X:109 or .X:110 or .X:118 or .X:215 or .X:242 or .X:243 or .X:244 or .X:246 or .X:247 or .X:308 or .X:329; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
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| PDB ID: 2FKF Phosphomannomutase/Phosphoglucomutase from Pseudomonas aeruginosa with alpha-D-glucose 1,6-bisphosphate bound | ||||||
| Method | X-ray diffraction | Resolution | 2.00 Å | Mutation | No | [4] |
| PDB Sequence |
LPASIFRAYD
18 IRGVVGDTLT28 AETAYWIGRA38 IGSESLARGE48 PCVAVGRDGR58 LSGPELVKQL 68 IQGLVDCGCQ78 VSDVGMVPTP88 VLYYAANVLE98 GKSGVMLTGH109 NPPDYNGFKI 119 VVAGETLANE129 QIQALRERIE139 KNDLASGVGS149 VEQVDILPRY159 FKQIRDDIAM 169 AKPMKVVVDC179 GNGVAGVIAP189 QLIEALGCSV199 IPLYCEVDGN209 FPNHHPDPGK 219 PENLKDLIAK229 VKAENADLGL239 AFDGDGDRVG249 VVTNTGTIIY259 PDRLLMLFAK 269 DVVSRNPGAD279 IIFDVKCTRR289 LIALISGYGG299 RPVMWKTGHS309 LIKKKMKETG 319 ALLAGEMSGH329 VFFKERWFGF339 DDGIYSAARL349 LEILSQDQRD359 SEHVFSAFPS 369 DISTPEINIT379 VTEDSKFAII389 EALQRDAQWG399 EGNITTLDGV409 RVDYPKGWGL 419 VRASNTTPVL429 VLRFEADTEE439 ELERIKTVFR449 NQLKAVDSSL459 PVPF |
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|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .SEP or .SEP2 or .SEP3 or :3SEP;style chemicals stick;color identity;select .A:18 or .A:20 or .A:56 or .A:58 or .A:106 or .A:107 or .A:109 or .A:110 or .A:118 or .A:215 or .A:242 or .A:243 or .A:244 or .A:246 or .A:247 or .A:329; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structural basis of diverse substrate recognition by the enzyme PMM/PGM from P. aeruginosa. Structure. 2004 Jan;12(1):55-63. | ||||
| REF 2 | Complexes of the enzyme phosphomannomutase/phosphoglucomutase with a slow substrate and an inhibitor. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Aug 1;62(Pt 8):722-6. | ||||
| REF 3 | Backbone flexibility, conformational change, and catalysis in a phosphohexomutase from Pseudomonas aeruginosa. Biochemistry. 2008 Sep 2;47(35):9154-62. | ||||
| REF 4 | The reaction of phosphohexomutase from Pseudomonas aeruginosa: structural insights into a simple processive enzyme. J Biol Chem. 2006 Jun 2;281(22):15564-71. | ||||
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