Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T85799 | Target Info | |||
| Target Name | Cyclin-dependent kinase 4 (CDK4) | ||||
| Synonyms | PSK-J3; Cell division protein kinase 4 | ||||
| Target Type | Successful Target | ||||
| Gene Name | CDK4 | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Abemaciclib | Ligand Info | |||||
| Structure Description | Structure of CDK4-Cyclin D3 bound to abemaciclib | PDB:7SJ3 | ||||
| Method | X-ray diffraction | Resolution | 2.51 Å | Mutation | Yes | [1] |
| PDB Sequence |
ATSRYEPVAE
11 IGVGAYGTVY21 KARDPHSGHF31 VALKSVRGGG48 LPISTVREVA58 LLRRLEAFEH 68 PNVVRLMDVC78 ATSDREIKVT90 LVFEHVDQDL100 RTYLDKAPAE115 TIKDLMRQFL 125 RGLDFLHANC135 IVHRDLKPEN145 ILVTSGGTVK155 LADFGLARIY165 SYQMALPVVV 176 TLWYRAPEVL186 LQSTYATPVD196 MWSVGCIFAE206 MFRRKPLFCG216 NSEADQLGKI 226 FDLIGLPPED236 DWPRDVSLPR246 GAFPPRGPRP262 EMEESGAQLL272 LEMLTFNPHK 282 RISAFRALQH292 SYL
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GLU11
4.190
ILE12
3.216
GLY13
4.193
TYR17
3.521
VAL20
3.911
ALA33
3.710
LYS35
3.057
GLU56
3.769
VAL72
3.871
PHE93
3.102
GLU94
3.344
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| Ligand Name: Phosphonothreonine | Ligand Info | |||||
| Structure Description | Structure of CDK4-Cyclin D3 bound to abemaciclib | PDB:7SJ3 | ||||
| Method | X-ray diffraction | Resolution | 2.51 Å | Mutation | Yes | [1] |
| PDB Sequence |
ATSRYEPVAE
11 IGVGAYGTVY21 KARDPHSGHF31 VALKSVRGGG48 LPISTVREVA58 LLRRLEAFEH 68 PNVVRLMDVC78 ATSDREIKVT90 LVFEHVDQDL100 RTYLDKAPAE115 TIKDLMRQFL 125 RGLDFLHANC135 IVHRDLKPEN145 ILVTSGGTVK155 LADFGLARIY165 SYQMALPVVV 176 TLWYRAPEVL186 LQSTYATPVD196 MWSVGCIFAE206 MFRRKPLFCG216 NSEADQLGKI 226 FDLIGLPPED236 DWPRDVSLPR246 GAFPPRGPRP262 EMEESGAQLL272 LEMLTFNPHK 282 RISAFRALQH292 SYL
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structure of CDK4-Cyclin D3 bound to abemaciclib | ||||
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