Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T85025 | Target Info | |||
| Target Name | Interleukin 7 receptor alpha (IL7R) | ||||
| Synonyms | Interleukin-7 receptor subunit alpha; IL-7RA; IL-7R-alpha; IL-7R subunit alpha; IL-7R alpha chain; IL-7 receptor subunit alpha; CDw127; CD127 antigen; CD127 | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | IL7R | ||||
| Biochemical Class | Cytokine receptor | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: alpha-L-Fucose | Ligand Info | |||||
| Structure Description | Crystal structure of the unliganded human interleukin-7 receptor extracellular domain | PDB:3UP1 | ||||
| Method | X-ray diffraction | Resolution | 2.15 Å | Mutation | Yes | [1] |
| PDB Sequence |
DAELDDYSFS
21 CYSQLEVNGS31 QHSLTCAFED41 PDVNTTNLEF51 EICGALVEVK61 CLNFRKLQEI 71 YFIETKKFLL81 IGKSNICVKV91 GEKSLTCKKI101 DLTTIVKPEA111 PFDLSVVYRE 121 GANDFVVTFN131 TSHLQKKYVK141 VLMHDVAYRQ151 EKDENKWTHV161 NLSSTKLTLL 171 QRKLQPAAMY181 EIKVRSIPDH191 YFKGFWSEWS201 PSYYFRTPEI211 N |
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structural reorganization of the interleukin-7 signaling complex. Proc Natl Acad Sci U S A. 2012 Feb 14;109(7):2503-8. | ||||
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