Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T85025 | Target Info | |||
| Target Name | Interleukin 7 receptor alpha (IL7R) | ||||
| Synonyms | Interleukin-7 receptor subunit alpha; IL-7RA; IL-7R-alpha; IL-7R subunit alpha; IL-7R alpha chain; IL-7 receptor subunit alpha; CDw127; CD127 antigen; CD127 | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | IL7R | ||||
| Biochemical Class | Cytokine receptor | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | alpha-L-Fucose | Ligand Info | |||
| Canonical SMILES | CC1C(C(C(C(O1)O)O)O)O | ||||
| InChI | 1S/C6H12O5/c1-2-3(7)4(8)5(9)6(10)11-2/h2-10H,1H3/t2-,3+,4+,5-,6+/m0/s1 | ||||
| InChIKey | SHZGCJCMOBCMKK-SXUWKVJYSA-N | ||||
| PubChem Compound ID | 439554 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 3UP1 Crystal structure of the unliganded human interleukin-7 receptor extracellular domain | ||||||
| Method | X-ray diffraction | Resolution | 2.15 Å | Mutation | Yes | [1] |
| PDB Sequence |
DAELDDYSFS
21 CYSQLEVNGS31 QHSLTCAFED41 PDVNTTNLEF51 EICGALVEVK61 CLNFRKLQEI 71 YFIETKKFLL81 IGKSNICVKV91 GEKSLTCKKI101 DLTTIVKPEA111 PFDLSVVYRE 121 GANDFVVTFN131 TSHLQKKYVK141 VLMHDVAYRQ151 EKDENKWTHV161 NLSSTKLTLL 171 QRKLQPAAMY181 EIKVRSIPDH191 YFKGFWSEWS201 PSYYFRTPEI211 N |
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| PDB ID: 6P67 Crystal Structure of a Complex of human IL-7Ralpha with an anti-IL-7Ralpha 2B8 Fab | ||||||
| Method | X-ray diffraction | Resolution | 2.90 Å | Mutation | No | [2] |
| PDB Sequence |
DYSFSCYSQL
26 EVNGSQHSLT36 CAFEDPDVNT46 TNLEFEICGA56 LVEVKCLNFR66 KLQEIYFIET 76 KKFLLIGKSN86 ICVKVGEKSL96 TCKKIDLTTI106 VKPEAPFDLS116 VVYREGANDF 126 VVTFNTSHLQ136 KKYVKVLMHD146 VAYRQEKDEN156 KWTHVNLSST166 KLTLLQRKLQ 176 PAAMYEIKVR186 SIPDHYFKGF196 WSEWSPSYYF206 RTPEI
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structural reorganization of the interleukin-7 signaling complex. Proc Natl Acad Sci U S A. 2012 Feb 14;109(7):2503-8. | ||||
| REF 2 | New anti-IL-7RAlpha monoclonal antibodies show efficacy against T cell acute lymphoblastic leukemia in pre-clinical models. Leukemia. 2020 Jan;34(1):35-49. | ||||
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