Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T83793 Target Info
Target Name Human immunodeficiency virus Negative factor (HIV nef)
Synonyms nef; Nef protein; F-protein; 3'ORF; 27 kDa protein
Target Type Clinical trial Target
Gene Name HIV nef
Biochemical Class Lentivirus primate group Nef
UniProt ID
NEF_HV1A2
Drug Binding Sites of Target  Top
Ligand Name: B-Octylglucoside Ligand Info
Structure Description A novel HIV-1 Nef dimer interface induced by a single octyl-glucoside molecule PDB:6B72
Method X-ray diffraction Resolution 3.20 Å Mutation No [1]
PDB Sequence
ADCAWLEAQE
62
EEEVGFPVRP
72
QVPLRPMTYK
82
AALDISHFLK
92
EKGGLEGLIW
102

SQRRQEILDL
112
WIYHTQGYFP
122
DWQNYTPGPG
132
IRYPLTFGWC
142
FKLVPVEEKE
179

VLVWRFDSKL
189
AFHHMARELH
199
PEYY
Residue
Distance (Å)
GLN73
4.088
ILE109
4.145
LEU112
3.888
Residue
Distance (Å)
TRP113
3.444
HIS116
3.411
THR117
4.210
References  Top
REF 1 A single Beta-octyl glucoside molecule induces HIV-1 Nef dimer formation in the absence of partner protein binding. PLoS One. 2018 Feb 7;13(2):e0192512.

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