Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T81409 | Target Info | |||
| Target Name | Septin-6 (SEPT6) | ||||
| Synonyms | KIAA0128 | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | SEPTIN6 | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Guanosine-5'-Diphosphate | Ligand Info | |||||
| Structure Description | Crystal Structure of GTPase Domain of Human Septin 2/Septin 6 Heterocomplex | PDB:6UPA | ||||
| Method | X-ray diffraction | Resolution | 2.51 Å | Mutation | No | [1] |
| PDB Sequence |
FCFNILCVGE
50 TGLGKSTLMD60 TLFNTKFEPA72 THTQPGVQLQ82 SNTYDLRLKL97 TIVSTVGFGD 107 QINKEDSYKP117 IVEFIDAQFE127 AYLQEELKIR137 RVLHTYHDSR147 IHVCLYFIAP 157 TGHSLKSLDL167 VTMKKLDSKV177 NIIPIIAKAD187 AISKSELTKF197 KIKITSELVS 207 NGVQIYQFPT217 DDESVAEING227 TMNAHLPFAV237 IGSTEELKIG247 NKMMRARQYP 257 WGTVQVENEA267 HCDFVKLREM277 LIRVNMEDLR287 EQTHTRHYEL297 YRRCKLEE |
|||||
|
|
||||||
| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: Guanosine-5'-Triphosphate | Ligand Info | |||||
| Structure Description | Crystal Structure of GTPase Domain of Human Septin 2/Septin 6 Heterocomplex | PDB:6UPA | ||||
| Method | X-ray diffraction | Resolution | 2.51 Å | Mutation | No | [1] |
| PDB Sequence |
FCFNILCVGE
50 TGLGKSTLMD60 TLFNTKFEPA72 THTQPGVQLQ82 SNTYDLRLKL97 TIVSTVGFGD 107 QINKEDSYKP117 IVEFIDAQFE127 AYLQEELKIR137 RVLHTYHDSR147 IHVCLYFIAP 157 TGHSLKSLDL167 VTMKKLDSKV177 NIIPIIAKAD187 AISKSELTKF197 KIKITSELVS 207 NGVQIYQFPT217 DDESVAEING227 TMNAHLPFAV237 IGSTEELKIG247 NKMMRARQYP 257 WGTVQVENEA267 HCDFVKLREM277 LIRVNMEDLR287 EQTHTRHYEL297 YRRCKLEE |
|||||
|
|
GLU50
4.092
THR51
3.569
GLY52
3.158
LEU53
3.229
GLY54
2.974
LYS55
2.528
SER56
2.806
THR57
2.680
GLU70
4.519
PRO71
3.518
ALA72
2.572
|
|||||
| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Molecular Recognition at Septin Interfaces: The Switches Hold the Key. J Mol Biol. 2020 Oct 2;432(21):5784-5801. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.