Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T80454 Target Info
Target Name T-lymphoma invasion and metastasis 1 (TIAM1)
Synonyms TIAM-1; T-lymphoma invasion and metastasis-inducing protein 1
Target Type Literature-reported Target
Gene Name TIAM1
UniProt ID
TIAM1_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: Phosphonotyrosine Ligand Info
Structure Description Crystal Structure of T-cell Lymphoma Invasion and Metastasis-1 PDZ in complex with phosphorylated Syndecan1 Peptide PDB:4GVC
Method X-ray diffraction Resolution 1.54 Å Mutation No [1]
PDB Sequence
GAMGKVTHSI
846
HIEKSDTAAD
856
TYGFSLSSVE
866
EDGIRRLYVN
876
SVKETGLASK
886

KGLKAGDEIL
896
EINNRAADAL
906
NSSMLKDFLS
916
QPSLGLLVRT
926
YPEL
Residue
Distance (Å)
THR857
2.878
GLY859
3.992
PHE860
3.279
SER861
3.919
Residue
Distance (Å)
LEU862
4.998
LYS879
3.052
LEU915
4.741
Ligand Name: 5-(Dimethylamino)naphthalene-1-sulfonic acid Ligand Info
Structure Description Crystal Structure of T-cell Lymphoma Invasion and Metastasis-1 PDZ in complex with phosphorylated Syndecan1 Peptide PDB:4GVC
Method X-ray diffraction Resolution 1.54 Å Mutation No [1]
PDB Sequence
GAMGKVTHSI
846
HIEKSDTAAD
856
TYGFSLSSVE
866
EDGIRRLYVN
876
SVKETGLASK
886

KGLKAGDEIL
896
EINNRAADAL
906
NSSMLKDFLS
916
QPSLGLLVRT
926
YPEL
Residue
Distance (Å)
SER863
4.345
VAL865
3.434
Residue
Distance (Å)
GLU867
4.086
TYR874
3.987
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References  Top
REF 1 The structure of the Tiam1 PDZ domain/ phospho-syndecan1 complex reveals a ligand conformation that modulates protein dynamics. Structure. 2013 Mar 5;21(3):342-54.

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