Binding Site Information of Target
Target General Information | Top | ||||
---|---|---|---|---|---|
Target ID | T80306 | Target Info | |||
Target Name | S-phase kinase-associated protein 2 (SKP2) | ||||
Synonyms | Skp2; P45skp2; FBXL1; F-box/LRR-repeat protein 1; F-box protein Skp2; Cyclin-A/CDK2-associated protein p45; Cyclin A/CDK2-associated protein p45; Cyclin A/CDK2-associated p45 | ||||
Target Type | Literature-reported Target | ||||
Gene Name | SKP2 | ||||
UniProt ID |
Drug Binding Sites of Target | Top | |||||
---|---|---|---|---|---|---|
Ligand Name: Benzamidine | Ligand Info | |||||
Structure Description | Crystal structure of Skp1-Skp2-Cks1 in complex with a p27 peptide | PDB:2AST | ||||
Method | X-ray diffraction | Resolution | 2.30 Å | Mutation | Yes | [1] |
PDB Sequence |
VSWDSLPDEL
2104 LLGIFSCLCL2114 PELLKVSGVC2124 KRWYRLASDE2134 SLWQTLDLTG2144 KNLHPDVTGR 2154 LLSQGVIAFR2164 CPRSFMDQPL2174 AEHFSPFRVQ2184 HMDLSNSVIE2194 VSTLHGILSQ 2204 CSKLQNLSLE2214 GLRLSDPIVN2224 TLAKNSNLVR2234 LNLSGCSGFS2244 EFALQTLLSS 2254 CSRLDELNLS2264 WCFDFTEKHV2274 QVAVAHVSET2284 ITQLNLSGYR2294 KNLQKSDLST 2304 LVRRCPNLVH2314 LDLSDSVMLK2324 NDCFQEFFQL2334 NYLQHLSLSR2344 CYDIIPETLL 2354 ELGEIPTLKT2364 LQVFGIVPDG2374 TLQLLKEALP2384 HLQINCSHFT2394 TIARPTIGNK 2404 KNQEIWGIKC2414 RLTLQ
|
|||||
|
||||||
Click to View More Binding Site Information of This Target and Ligand Pair |
References | Top | ||||
---|---|---|---|---|---|
REF 1 | Structural basis of the Cks1-dependent recognition of p27(Kip1) by the SCF(Skp2) ubiquitin ligase. Mol Cell. 2005 Oct 7;20(1):9-19. |
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.