Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T80306 | Target Info | |||
| Target Name | S-phase kinase-associated protein 2 (SKP2) | ||||
| Synonyms | Skp2; P45skp2; FBXL1; F-box/LRR-repeat protein 1; F-box protein Skp2; Cyclin-A/CDK2-associated protein p45; Cyclin A/CDK2-associated protein p45; Cyclin A/CDK2-associated p45 | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | SKP2 | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | Benzamidine | Ligand Info | |||
| Canonical SMILES | C1=CC=C(C=C1)C(=N)N | ||||
| InChI | 1S/C7H8N2/c8-7(9)6-4-2-1-3-5-6/h1-5H,(H3,8,9) | ||||
| InChIKey | PXXJHWLDUBFPOL-UHFFFAOYSA-N | ||||
| PubChem Compound ID | 2332 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 2AST Crystal structure of Skp1-Skp2-Cks1 in complex with a p27 peptide | ||||||
| Method | X-ray diffraction | Resolution | 2.30 Å | Mutation | Yes | [1] |
| PDB Sequence |
VSWDSLPDEL
2104 LLGIFSCLCL2114 PELLKVSGVC2124 KRWYRLASDE2134 SLWQTLDLTG2144 KNLHPDVTGR 2154 LLSQGVIAFR2164 CPRSFMDQPL2174 AEHFSPFRVQ2184 HMDLSNSVIE2194 VSTLHGILSQ 2204 CSKLQNLSLE2214 GLRLSDPIVN2224 TLAKNSNLVR2234 LNLSGCSGFS2244 EFALQTLLSS 2254 CSRLDELNLS2264 WCFDFTEKHV2274 QVAVAHVSET2284 ITQLNLSGYR2294 KNLQKSDLST 2304 LVRRCPNLVH2314 LDLSDSVMLK2324 NDCFQEFFQL2334 NYLQHLSLSR2344 CYDIIPETLL 2354 ELGEIPTLKT2364 LQVFGIVPDG2374 TLQLLKEALP2384 HLQINCSHFT2394 TIARPTIGNK 2404 KNQEIWGIKC2414 RLTLQ
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| PDB ID: 2ASS Crystal structure of the Skp1-Skp2-Cks1 complex | ||||||
| Method | X-ray diffraction | Resolution | 3.00 Å | Mutation | Yes | [1] |
| PDB Sequence |
VSWDSLPDEL
2104 LLGIFSCLCL2114 PELLKVSGVC2124 KRWYRLASDE2134 SLWQTLDLTG2144 KNLHPDVTGR 2154 LLSQGVIAFR2164 CPRSFMDQPL2174 AEHFSPFRVQ2184 HMDLSNSVIE2194 VSTLHGILSQ 2204 CSKLQNLSLE2214 GLRLSDPIVN2224 TLAKNSNLVR2234 LNLSGCSGFS2244 EFALQTLLSS 2254 CSRLDELNLS2264 WCFDFTEKHV2274 QVAVAHVSET2284 ITQLNLSGYR2294 KNLQKSDLST 2304 LVRRCPNLVH2314 LDLSDSVMLK2324 NDCFQEFFQL2334 NYLQHLSLSR2344 CYDIIPETLL 2354 ELGEIPTLKT2364 LQVFGIVPDG2374 TLQLLKEALP2384 HLQINCSHFT2394 TIARPTIGNK 2404 KNQEIWGIKC2414 RLTLQ
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structural basis of the Cks1-dependent recognition of p27(Kip1) by the SCF(Skp2) ubiquitin ligase. Mol Cell. 2005 Oct 7;20(1):9-19. | ||||
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