Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T78205 | Target Info | |||
| Target Name | Long transient receptor potential channel 2 (TRPM2) | ||||
| Synonyms | TrpC7; Transient receptor potential melastatin 2; Transient receptor potential channel 7; Transient receptor potential cation channel subfamily M member 2; LTrpC2; LTrpC-2; Estrogen-responsive element-associated gene 1 protein; EREG1 | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | TRPM2 | ||||
| Biochemical Class | Transient receptor potential catioin channel | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Adenosine-5-diphosphoribose | Ligand Info | |||||
| Structure Description | Human TRPM2 bound to ADPR and calcium | PDB:6PUS | ||||
| Method | Electron microscopy | Resolution | 3.70 Å | Mutation | No | [1] |
| PDB Sequence |
QESLSSWIPE
65 NIKKKECVYF75 VESSKLSDAG85 KVVCQCGYTH95 EQHLEEATKP105 HTFQGTQWDP 115 KKHVQEMPTD125 AFGDIVFTGL135 SQKVKKYVRV145 SQDTPSSVIY155 HLMTQHWGLD 165 VPNLLISVTG175 GAKNFNMKPR185 LKSIFRRGLV195 KVAQTTGAWI205 ITGGSHTGVM 215 KQVGEAVRDF225 SLSSSYKEGE235 LITIGVATWG245 TVHRREGLIH255 PTGSFPAEYI 265 LDEDGQGNLT275 CLDSNHSHFI285 LVDDGTHGQY295 GVEIPLRTRL305 EKFISEQTKE 315 RGGVAIKIPI325 VCVVLEGGPG335 TLHTIDNATT345 NGTPCVVVEG355 SGRVADVIAQ 365 VANLPVSDIT375 ISLIQQKLSV385 FFQEMFETFT395 ESRIVEWTKK405 IQDIVRRRQL 415 LTVFREGKDG425 QQDVDVAILQ435 ALLKASRSQD445 HFGHENWDHQ455 LKLAVAWNRV 465 DIARSEIFMD475 EWQWKPSDLH485 PTMTAALISN495 KPEFVKLFLE505 NGVQLKEFVT 515 WDTLLYLYEN525 LDPSCLFHSK535 LQKVLVEDPE545 RPACAPAAPR555 LQMHHVAQVL 565 RELLGDFTQP575 LYPRPRHGHV615 TFTMDPIRDL625 LIWAIVQNRR635 ELAGIIWAQS 645 QDCIAAALAC655 SKILKELSKE665 EEDTDSSEEM675 LALAEEYEHR685 AIGVFTECYR 695 KDEERAQKLL705 TRVSEAWGKT715 TCLQLALEAK725 DMKFVSHGGI735 QAFLTKVWWG 745 QLSVDNGLWR755 VTLCMLAFPL765 LLTGLISFRE775 KRLQDVGTPA785 ARARAFFTAP 795 VVVFHLNILS805 YFAFLCLFAY815 VLMVDFQPVP825 SWCECAIYLW835 LFSLVCEEMR 845 QLFYDPDECG855 LMKKAALYFS865 DFWNKLDVGA875 ILLFVAGLTC885 RLIPATLYPG 895 RVILSLDFIL905 FCLRLMHIFT915 ISKTLGPKII925 IVKRMMKDVF935 FFLFLLAVWV 945 VSFGVAKQAI955 LIHNERRVDW965 LFRGAVYHSY975 LTIFGFPEWL1024 TVLLLCLYLL 1034 FTNILLLNLL1044 IAMFNYTFQQ1054 VQEHTDQIWK1064 FQRHDLIEEY1074 HGRPAAPPPF 1084 ILLSHLQLFI1094 KRVVLKRHKQ1108 LKNKLEKNEE1118 AALLSWEIYL1128 KENYLQNRQF 1138 QQKQRPEQKI1148 EDISNKVDAM1158 VDLLDLDGDS1237 YHVNARHLLY1247 PNCPVTRFPV 1257 PNEKVPWETE1267 FLIYDPPFYT1277 AERKDAAAMD1287 PMGDTLEPLS1297 TIQYNVVDGL 1307 RDRRSFHGPY1317 TVQAGLPLNP1327 MGRTGLRGRG1337 SLSCFGPNHT1347 LYPMVTRWRR 1357 NEDGAICRKS1367 IKKMLEVLVV1377 KLPLSEHWAL1387 PGGSREPGEM1397 LPRKLKRILR 1407 QEHWPSFENL1417 LKCGMEVYKG1427 YMDDPRNTDN1437 AWIETVAVSV1447 HFQDQNDVEL 1457 NRLNSNLHAC1467 DSGASIRWQV1477 VDRRIPLYAN1487 HKTLLQKAAA1497 EFGAHY |
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VAL173
4.894
THR174
3.036
GLY175
2.984
GLY176
3.262
ALA177
3.410
LYS178
3.445
ASN179
2.783
GLY208
4.822
SER210
3.959
THR212
4.067
MET215
4.604
THR275
4.023
TYR295
3.241
ILE299
4.823
ARG302
2.750
GLY332
3.955
GLY333
2.885
|
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: 1,5-[1-Deoxy-beta-D-ribofuranose-1,5-O-diyl(oxylatophosphinylidene)oxy(oxylatophosphinylidene)(1-deoxy-beta-D-ribofuranose-5-O,1-diyl)]-2-bromo-4-amino-1,3,7-triaza-5-azonia-1H-indene | Ligand Info | |||||
| Structure Description | Human TRPM2 bound to 8-Br-cADPR and calcium | PDB:6PUU | ||||
| Method | Electron microscopy | Resolution | 3.70 Å | Mutation | No | [1] |
| PDB Sequence |
QESLSSWIPE
65 NIKKKECVYF75 VESSKLSDAG85 KVVCQCGYTH95 EQHLEEATKP105 HTFQGTQWDP 115 KKHVQEMPTD125 AFGDIVFTGL135 SQKVKKYVRV145 SQDTPSSVIY155 HLMTQHWGLD 165 VPNLLISVTG175 GAKNFNMKPR185 LKSIFRRGLV195 KVAQTTGAWI205 ITGGSHTGVM 215 KQVGEAVRDF225 SLSSSYKEGE235 LITIGVATWG245 TVHRREGLIH255 PTGSFPAEYI 265 LDEDGQGNLT275 CLDSNHSHFI285 LVDDGTHGQY295 GVEIPLRTRL305 EKFISEQTKE 315 RGGVAIKIPI325 VCVVLEGGPG335 TLHTIDNATT345 NGTPCVVVEG355 SGRVADVIAQ 365 VANLPVSDIT375 ISLIQQKLSV385 FFQEMFETFT395 ESRIVEWTKK405 IQDIVRRRQL 415 LTVFREGKDG425 QQDVDVAILQ435 ALLKASRSQD445 HFGHENWDHQ455 LKLAVAWNRV 465 DIARSEIFMD475 EWQWKPSDLH485 PTMTAALISN495 KPEFVKLFLE505 NGVQLKEFVT 515 WDTLLYLYEN525 LDPSCLFHSK535 LQKVLVEDPE545 RPACAPAAPR555 LQMHHVAQVL 565 RELLGDFTQP575 LYPRPRHHVT616 FTMDPIRDLL626 IWAIVQNRRE636 LAGIIWAQSQ 646 DCIAAALACS656 KILKELSKEE666 EDTDSSEEML676 ALAEEYEHRA686 IGVFTECYRK 696 DEERAQKLLT706 RVSEAWGKTT716 CLQLALEAKD726 MKFVSHGGIQ736 AFLTKVWWGQ 746 LSVDNGLWRV756 TLCMLAFPLL766 LTGLISFREK776 RLQDVGTPAA786 RARAFFTAPV 796 VVFHLNILSY806 FAFLCLFAYV816 LMVDFQPVPS826 WCECAIYLWL836 FSLVCEEMRQ 846 LFYDPDECGL856 MKKAALYFSD866 FWNKLDVGAI876 LLFVAGLTCR886 LIPATLYPGR 896 VILSLDFILF906 CLRLMHIFTI916 SKTLGPKIII926 VKRMMKDVFF936 FLFLLAVWVV 946 SFGVAKQAIL956 IHNERRVDWL966 FRGAVYHSYL976 TIFGFPEWLT1025 VLLLCLYLLF 1035 TNILLLNLLI1045 AMFNYTFQQV1055 QEHTDQIWKF1065 QRHDLIEEYH1075 GRPAAPPPFI 1085 LLSHLQLFIK1095 RVVLKTPAKR1105 HKQLKNKLEK1115 NEEAALLSWE1125 IYLKENYLQN 1135 RQFQQKQRPE1145 QKIEDISNKV1155 DAMVDLLDLD1165 GDSYHVNARH1244 LLYPNCPVTR 1254 FPVPNEKVPW1264 ETEFLIYDPP1274 FYTAERKDAA1284 AMDPMGDTLE1294 PLSTIQYNVV 1304 DGLRDRRSFH1314 GPYTVQAGLP1324 LNPMGRTGLR1334 GRGSLSCFGP1344 NHTLYPMVTR 1354 WRRNEDGAIC1364 RKSIKKMLEV1374 LVVKLPLSEH1384 WALPGGSREP1394 GEMLPRKLKR 1404 ILRQEHWPSF1414 ENLLKCGMEV1424 YKGYMDDPRN1434 TDNAWIETVA1444 VSVHFQDQND 1454 VELNRLNSNL1464 HACDSGASIR1474 WQVVDRRIPL1484 YANHKTLLQK1494 AAAEFGAHY |
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Ligand recognition and gating mechanism through three ligand-binding sites of human TRPM2 channel. Elife. 2019 Sep 12;8:e50175. | ||||
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