Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T78205 | Target Info | |||
| Target Name | Long transient receptor potential channel 2 (TRPM2) | ||||
| Synonyms | TrpC7; Transient receptor potential melastatin 2; Transient receptor potential channel 7; Transient receptor potential cation channel subfamily M member 2; LTrpC2; LTrpC-2; Estrogen-responsive element-associated gene 1 protein; EREG1 | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | TRPM2 | ||||
| Biochemical Class | Transient receptor potential catioin channel | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | Adenosine-5-diphosphoribose | Ligand Info | |||
| Canonical SMILES | C1=NC(=C2C(=N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OCC4C(C(C(O4)O)O)O)O)O)N | ||||
| InChI | 1S/C15H23N5O14P2/c16-12-7-13(18-3-17-12)20(4-19-7)14-10(23)8(21)5(32-14)1-30-35(26,27)34-36(28,29)31-2-6-9(22)11(24)15(25)33-6/h3-6,8-11,14-15,21-25H,1-2H2,(H,26,27)(H,28,29)(H2,16,17,18)/t5-,6-,8-,9-,10-,11-,14-,15+/m1/s1 | ||||
| InChIKey | SRNWOUGRCWSEMX-ZQSHOCFMSA-N | ||||
| PubChem Compound ID | 447048 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 6PUS Human TRPM2 bound to ADPR and calcium | ||||||
| Method | Electron microscopy | Resolution | 3.70 Å | Mutation | No | [1] |
| PDB Sequence |
QESLSSWIPE
65 NIKKKECVYF75 VESSKLSDAG85 KVVCQCGYTH95 EQHLEEATKP105 HTFQGTQWDP 115 KKHVQEMPTD125 AFGDIVFTGL135 SQKVKKYVRV145 SQDTPSSVIY155 HLMTQHWGLD 165 VPNLLISVTG175 GAKNFNMKPR185 LKSIFRRGLV195 KVAQTTGAWI205 ITGGSHTGVM 215 KQVGEAVRDF225 SLSSSYKEGE235 LITIGVATWG245 TVHRREGLIH255 PTGSFPAEYI 265 LDEDGQGNLT275 CLDSNHSHFI285 LVDDGTHGQY295 GVEIPLRTRL305 EKFISEQTKE 315 RGGVAIKIPI325 VCVVLEGGPG335 TLHTIDNATT345 NGTPCVVVEG355 SGRVADVIAQ 365 VANLPVSDIT375 ISLIQQKLSV385 FFQEMFETFT395 ESRIVEWTKK405 IQDIVRRRQL 415 LTVFREGKDG425 QQDVDVAILQ435 ALLKASRSQD445 HFGHENWDHQ455 LKLAVAWNRV 465 DIARSEIFMD475 EWQWKPSDLH485 PTMTAALISN495 KPEFVKLFLE505 NGVQLKEFVT 515 WDTLLYLYEN525 LDPSCLFHSK535 LQKVLVEDPE545 RPACAPAAPR555 LQMHHVAQVL 565 RELLGDFTQP575 LYPRPRHGHV615 TFTMDPIRDL625 LIWAIVQNRR635 ELAGIIWAQS 645 QDCIAAALAC655 SKILKELSKE665 EEDTDSSEEM675 LALAEEYEHR685 AIGVFTECYR 695 KDEERAQKLL705 TRVSEAWGKT715 TCLQLALEAK725 DMKFVSHGGI735 QAFLTKVWWG 745 QLSVDNGLWR755 VTLCMLAFPL765 LLTGLISFRE775 KRLQDVGTPA785 ARARAFFTAP 795 VVVFHLNILS805 YFAFLCLFAY815 VLMVDFQPVP825 SWCECAIYLW835 LFSLVCEEMR 845 QLFYDPDECG855 LMKKAALYFS865 DFWNKLDVGA875 ILLFVAGLTC885 RLIPATLYPG 895 RVILSLDFIL905 FCLRLMHIFT915 ISKTLGPKII925 IVKRMMKDVF935 FFLFLLAVWV 945 VSFGVAKQAI955 LIHNERRVDW965 LFRGAVYHSY975 LTIFGFPEWL1024 TVLLLCLYLL 1034 FTNILLLNLL1044 IAMFNYTFQQ1054 VQEHTDQIWK1064 FQRHDLIEEY1074 HGRPAAPPPF 1084 ILLSHLQLFI1094 KRVVLKRHKQ1108 LKNKLEKNEE1118 AALLSWEIYL1128 KENYLQNRQF 1138 QQKQRPEQKI1148 EDISNKVDAM1158 VDLLDLDGDS1237 YHVNARHLLY1247 PNCPVTRFPV 1257 PNEKVPWETE1267 FLIYDPPFYT1277 AERKDAAAMD1287 PMGDTLEPLS1297 TIQYNVVDGL 1307 RDRRSFHGPY1317 TVQAGLPLNP1327 MGRTGLRGRG1337 SLSCFGPNHT1347 LYPMVTRWRR 1357 NEDGAICRKS1367 IKKMLEVLVV1377 KLPLSEHWAL1387 PGGSREPGEM1397 LPRKLKRILR 1407 QEHWPSFENL1417 LKCGMEVYKG1427 YMDDPRNTDN1437 AWIETVAVSV1447 HFQDQNDVEL 1457 NRLNSNLHAC1467 DSGASIRWQV1477 VDRRIPLYAN1487 HKTLLQKAAA1497 EFGAHY |
|||||
|
|
VAL173
4.894
THR174
3.036
GLY175
2.984
GLY176
3.262
ALA177
3.410
LYS178
3.445
ASN179
2.783
GLY208
4.822
SER210
3.959
THR212
4.067
MET215
4.604
THR275
4.023
TYR295
3.241
ILE299
4.823
ARG302
2.750
GLY332
3.955
GLY333
2.885
|
|||||
| PDB ID: 6PUR Human TRPM2 bound to ADPR | ||||||
| Method | Electron microscopy | Resolution | 4.40 Å | Mutation | No | [1] |
| PDB Sequence |
QESLSSWIPE
65 NIKKKECVYF75 VESSKLSDAG85 KVVCQCGYTH95 EQHLEEATKP105 HTFQGTQWDP 115 KKHVQEMPTD125 AFGDIVFTGL135 SQKVKKYVRV145 SQDTPSSVIY155 HLMTQHWGLD 165 VPNLLISVTG175 GAKNFNMKPR185 LKSIFRRGLV195 KVAQTTGAWI205 ITGGSHTGVM 215 KQVGEAVRDF225 SLSSSYKEGE235 LITIGVATWG245 TVHRREGLIH255 PTGSFPAEYI 265 LDEDGQGNLT275 CLDSNHSHFI285 LVDDGTHGQY295 GVEIPLRTRL305 EKFISEQTKE 315 RGGVAIKIPI325 VCVVLEGGPG335 TLHTIDNATT345 NGTPCVVVEG355 SGRVADVIAQ 365 VANLPVSDIT375 ISLIQQKLSV385 FFQEMFETFT395 ESRIVEWTKK405 IQDIVRRRQL 415 LTVFREGKDG425 QQDVDVAILQ435 ALLKASRSQD445 HFGHENWDHQ455 LKLAVAWNRV 465 DIARSEIFMD475 EWQWKPSDLH485 PTMTAALISN495 KPEFVKLFLE505 NGVQLKEFVT 515 WDTLLYLYEN525 LDPSCLFHSK535 LQKVLVEDPE545 RPACAPAAPR555 LQMHHVAQVL 565 RELLGDFTQP575 LYPRPRHGHV615 TFTMDPIRDL625 LIWAIVQNRR635 ELAGIIWAQS 645 QDCIAAALAC655 SKILKELSKE665 EEDTDSSEEM675 LALAEEYEHR685 AIGVFTECYR 695 KDEERAQKLL705 TRVSEAWGKT715 TCLQLALEAK725 DMKFVSHGGI735 QAFLTKVWWG 745 QLSVDNGLWR755 VTLCMLAFPL765 LLTGLISFRE775 KRLQDVGTPA785 ARARAFFTAP 795 VVVFHLNILS805 YFAFLCLFAY815 VLMVDFQPVP825 SWCECAIYLW835 LFSLVCEEMR 845 QLFYDPDECG855 LMKKAALYFS865 DFWNKLDVGA875 ILLFVAGLTC885 RLIPATLYPG 895 RVILSLDFIL905 FCLRLMHIFT915 ISKTLGPKII925 IVKRMMKDVF935 FFLFLLAVWV 945 VSFGVAKQAI955 LIHNERRVDW965 LFRGAVYHSY975 LTIFGFPEWL1024 TVLLLCLYLL 1034 FTNILLLNLL1044 IAMFNYTFQQ1054 VQEHTDQIWK1064 FQRHDLIEEY1074 HGRPAAPPPF 1084 ILLSHLQLFI1094 KRVVLKRHKQ1108 LKNKLEKNEE1118 AALLSWEIYL1128 KENYLQNRQF 1138 QQKQRPEQKI1148 EDISNKVDAM1158 VDLLDLDGDS1237 YHVNARHLLY1247 PNCPVTRFPV 1257 PNEKVPWETE1267 FLIYDPPFYT1277 AERKDAAAMD1287 PMGDTLEPLS1297 TIQYNVVDGL 1307 RDRRSFHGPY1317 TVQAGLPLNP1327 MGRTGLRGRG1337 SLSCFGPNHT1347 LYPMVTRWRR 1357 NEDGAICRKS1367 IKKMLEVLVV1377 KLPLSEHWAL1387 PGGSREPGEM1397 LPRKLKRILR 1407 QEHWPSFENL1417 LKCGMEVYKG1427 YMDDPRNTDN1437 AWIETVAVSV1447 HFQDQNDVEL 1457 NRLNSNLHAC1467 DSGASIRWQV1477 VDRRIPLYAN1487 HKTLLQKAAA1497 EFGAHY |
|||||
|
|
VAL173
4.907
THR174
3.038
GLY175
2.977
GLY176
3.275
ALA177
3.420
LYS178
3.434
ASN179
2.765
GLY208
4.831
SER210
3.964
THR212
4.067
MET215
4.600
THR275
4.014
TYR295
3.247
ILE299
4.828
ARG302
2.761
GLY332
3.953
GLY333
2.882
|
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Ligand recognition and gating mechanism through three ligand-binding sites of human TRPM2 channel. Elife. 2019 Sep 12;8:e50175. | ||||
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